Mateo Sokac

A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer

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DOI

  • Yin Wu, University College London, The Francis Crick Institute, King’s College London
  • ,
  • Dhruva Biswas, University College London, The Francis Crick Institute
  • ,
  • Ieva Usaite, University College London
  • ,
  • Mihaela Angelova, The Francis Crick Institute
  • ,
  • Stefan Boeing, The Francis Crick Institute
  • ,
  • Takahiro Karasaki, University College London, The Francis Crick Institute
  • ,
  • Selvaraju Veeriah, University College London
  • ,
  • Justyna Czyzewska-Khan, University College London
  • ,
  • Cienne Morton, King’s College London
  • ,
  • Magdalene Joseph, King’s College London, The Francis Crick Institute
  • ,
  • Sonya Hessey, University College London
  • ,
  • James Reading, University College London
  • ,
  • Andrew Georgiou, University College London
  • ,
  • Maise Al-Bakir, The Francis Crick Institute
  • ,
  • TRACERx Consortium

Murine tissues harbor signature γδ T cell compartments with profound yet differential impacts on carcinogenesis. Conversely, human tissue-resident γδ cells are less well defined. In the present study, we show that human lung tissues harbor a resident Vδ1 γδ T cell population. Moreover, we demonstrate that Vδ1 T cells with resident memory and effector memory phenotypes were enriched in lung tumors compared with nontumor lung tissues. Intratumoral Vδ1 T cells possessed stem-like features and were skewed toward cytolysis and helper T cell type 1 function, akin to intratumoral natural killer and CD8+ T cells considered beneficial to the patient. Indeed, ongoing remission post-surgery was significantly associated with the numbers of CD45RACD27 effector memory Vδ1 T cells in tumors and, most strikingly, with the numbers of CD103+ tissue-resident Vδ1 T cells in nonmalignant lung tissues. Our findings offer basic insights into human body surface immunology that collectively support integrating Vδ1 T cell biology into immunotherapeutic strategies for nonsmall cell lung cancer.

OriginalsprogEngelsk
TidsskriftNature Cancer
Vol/bind3
Nummer6
Sider (fra-til)696-709
Antal sider14
DOI
StatusUdgivet - maj 2022

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