Martin Hansen

Fate and antibacterial potency of anticoccidial drugs and their main abiotic degradation products.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Standard

Fate and antibacterial potency of anticoccidial drugs and their main abiotic degradation products. / Hansen, Martin; Krogh, Kristine A; Brandt, Asbjørn; Christensen, Jan H.; Halling-Sørensen, Bent.

I: Environmental pollution (Barking, Essex : 1987), Bind 157, Nr. 2, 01.02.2009, s. 474-480.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Harvard

Hansen, M, Krogh, KA, Brandt, A, Christensen, JH & Halling-Sørensen, B 2009, 'Fate and antibacterial potency of anticoccidial drugs and their main abiotic degradation products.', Environmental pollution (Barking, Essex : 1987), bind 157, nr. 2, s. 474-480. <http://linkinghub.elsevier.com/retrieve/pii/S0269749108004661>

APA

Hansen, M., Krogh, K. A., Brandt, A., Christensen, J. H., & Halling-Sørensen, B. (2009). Fate and antibacterial potency of anticoccidial drugs and their main abiotic degradation products. Environmental pollution (Barking, Essex : 1987), 157(2), 474-480. http://linkinghub.elsevier.com/retrieve/pii/S0269749108004661

CBE

Hansen M, Krogh KA, Brandt A, Christensen JH, Halling-Sørensen B. 2009. Fate and antibacterial potency of anticoccidial drugs and their main abiotic degradation products. Environmental pollution (Barking, Essex : 1987). 157(2):474-480.

MLA

Hansen, Martin o.a.. "Fate and antibacterial potency of anticoccidial drugs and their main abiotic degradation products.". Environmental pollution (Barking, Essex : 1987). 2009, 157(2). 474-480.

Vancouver

Hansen M, Krogh KA, Brandt A, Christensen JH, Halling-Sørensen B. Fate and antibacterial potency of anticoccidial drugs and their main abiotic degradation products. Environmental pollution (Barking, Essex : 1987). 2009 feb 1;157(2):474-480.

Author

Hansen, Martin ; Krogh, Kristine A ; Brandt, Asbjørn ; Christensen, Jan H. ; Halling-Sørensen, Bent. / Fate and antibacterial potency of anticoccidial drugs and their main abiotic degradation products. I: Environmental pollution (Barking, Essex : 1987). 2009 ; Bind 157, Nr. 2. s. 474-480.

Bibtex

@article{1b795b94f3d145a09ed9f84855ef9194,

title = "Fate and antibacterial potency of anticoccidial drugs and their main abiotic degradation products.",

abstract = "The antibacterial potency of eight anticoccidial drugs was tested in a soil bacteria bioassay (pour plate method), EC(50)-values between 2.4 and 19.6 microM were obtained; however, one compound, nicarbazin exhibited an EC(50)-value above the maximum tested concentration (21 microM, 9.1 mg L(-1)). The potency of mixtures of two of the compounds, narasin and nicarbazin, was synergistic (more than additive) with 10-fold greater antibacterial potency of the mixture than can be explained by their individual EC(50)-values. The influence of pH, temperature, oxygen concentration and light on the transformation of robenidine and salinomycin was investigated. Robenidine was transformed by photolysis (DT(50) of 4.1 days) and was unstable at low pH (DT(50) of approximately 4 days); salinomycin was merely transformed at low pH, the latter into an unknown number of products. The antibacterial potency of the mixtures of transformation products of robenidine after photolysis and at low pH was comparable with that of the parent compound. Finally five photo-transformation products of robenidine were structural elucidated by accurate mass measurements, i-FIT values (isotopic pattern fit) and MS/MS fragmentation patterns.",

author = "Martin Hansen and Krogh, {Kristine A} and Asbj{\o}rn Brandt and Christensen, {Jan H.} and Bent Halling-S{\o}rensen",

year = "2009",

month = feb,

day = "1",

language = "English",

volume = "157",

pages = "474--480",

journal = "Environmental pollution (Barking, Essex : 1987)",

number = "2",

}

RIS

TY - JOUR

T1 - Fate and antibacterial potency of anticoccidial drugs and their main abiotic degradation products.

AU - Hansen, Martin

AU - Krogh, Kristine A

AU - Brandt, Asbjørn

AU - Christensen, Jan H.

AU - Halling-Sørensen, Bent

PY - 2009/2/1

Y1 - 2009/2/1

N2 - The antibacterial potency of eight anticoccidial drugs was tested in a soil bacteria bioassay (pour plate method), EC(50)-values between 2.4 and 19.6 microM were obtained; however, one compound, nicarbazin exhibited an EC(50)-value above the maximum tested concentration (21 microM, 9.1 mg L(-1)). The potency of mixtures of two of the compounds, narasin and nicarbazin, was synergistic (more than additive) with 10-fold greater antibacterial potency of the mixture than can be explained by their individual EC(50)-values. The influence of pH, temperature, oxygen concentration and light on the transformation of robenidine and salinomycin was investigated. Robenidine was transformed by photolysis (DT(50) of 4.1 days) and was unstable at low pH (DT(50) of approximately 4 days); salinomycin was merely transformed at low pH, the latter into an unknown number of products. The antibacterial potency of the mixtures of transformation products of robenidine after photolysis and at low pH was comparable with that of the parent compound. Finally five photo-transformation products of robenidine were structural elucidated by accurate mass measurements, i-FIT values (isotopic pattern fit) and MS/MS fragmentation patterns.

AB - The antibacterial potency of eight anticoccidial drugs was tested in a soil bacteria bioassay (pour plate method), EC(50)-values between 2.4 and 19.6 microM were obtained; however, one compound, nicarbazin exhibited an EC(50)-value above the maximum tested concentration (21 microM, 9.1 mg L(-1)). The potency of mixtures of two of the compounds, narasin and nicarbazin, was synergistic (more than additive) with 10-fold greater antibacterial potency of the mixture than can be explained by their individual EC(50)-values. The influence of pH, temperature, oxygen concentration and light on the transformation of robenidine and salinomycin was investigated. Robenidine was transformed by photolysis (DT(50) of 4.1 days) and was unstable at low pH (DT(50) of approximately 4 days); salinomycin was merely transformed at low pH, the latter into an unknown number of products. The antibacterial potency of the mixtures of transformation products of robenidine after photolysis and at low pH was comparable with that of the parent compound. Finally five photo-transformation products of robenidine were structural elucidated by accurate mass measurements, i-FIT values (isotopic pattern fit) and MS/MS fragmentation patterns.

M3 - Journal article

VL - 157

SP - 474

EP - 480

JO - Environmental pollution (Barking, Essex : 1987)

JF - Environmental pollution (Barking, Essex : 1987)

IS - 2

ER -