Martin Hansen

ERGO: Breaking down the wall between human health and environmental testing of endocrine disrupters

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Henrik Holbech, Syddansk Universitet
  • ,
  • Peter Matthiessen, Matthiessen Consultancy
  • ,
  • Martin Hansen
  • Gerrit Schüürmann, Helmholtz Centre for Environmental Research, Freiberg University of Mining and Technology
  • ,
  • Dries Knapen, University of Antwerp
  • ,
  • Marieke Reuver, AquaTT
  • ,
  • Frédéric Flamant, Universite Claude Bernard Lyon 1
  • ,
  • Laurent Sachs, Museum National d'Histoire Naturelle
  • ,
  • Werner Kloas, Leibniz-Institute of Freshwater Ecology and Inland Fisheries
  • ,
  • Klara Hilscherova, Masaryk University
  • ,
  • Marc Leonard, L'Oreal
  • ,
  • Jürgen Arning, German Environment Agency
  • ,
  • Volker Strauss, BASF
  • ,
  • Taisen Iguchi, Yokohama City University
  • ,
  • Lisa Baumann, Heidelberg University 

ERGO (EndocRine Guideline Optimization) is the acronym of a European Union-funded research and innovation action, that aims to break down the wall between mammalian and non-mammalian vertebrate regulatory testing of endocrine disruptors (EDs), by identifying, developing and aligning thyroid-related biomarkers and endpoints (B/E) for the linkage of effects between vertebrate classes. To achieve this, an adverse outcome pathway (AOP) network covering various modes of thyroid hormone disruption (THD) in multiple vertebrate classes will be developed. The AOP development will be based on existing and new data from in vitro and in vivo experiments with fish, amphibians and mammals, using a battery of different THDs. This will provide the scientifically plausible and evidence-based foundation for the selection of B/E and assays in lower vertebrates, predictive of human health outcomes. These assays will be prioritized for validation at OECD (Organization for Economic Cooperation and Development) level. ERGO will re-think ED testing strategies from in silico methods to in vivo testing and develop, optimize and validate existing in vivo and early life-stage OECD guidelines, as well as new in vitro protocols for THD. This strategy will reduce requirements for animal testing by preventing duplication of testing in mammals and non-mammalian vertebrates and increase the screening capacity to enable more chemicals to be tested for ED properties.

OriginalsprogEngelsk
Artikelnummer2954
TidsskriftInternational Journal of Molecular Sciences
Vol/bind21
Nummer8
Antal sider18
ISSN1661-6596
DOI
StatusUdgivet - 2 apr. 2020

Se relationer på Aarhus Universitet Citationsformater

ID: 189878787