Aarhus Universitets segl

Marianne Overgaard Hesselager

The impact of α1-2 fucosyltransferase 1 (FUT1) on pig gut health

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandling

Rekvirerende organGraduate School of Science and Technology
StatusUdgivet - 27 aug. 2015

Note vedr. afhandling

During her studies, Marianne O. Hesselager researched sugar structures present in pig intestinal linings. Marianne studied how a naturally occurring gene variant alters the expression of some sugar structures, critically important to pathogenic as well as beneficial bacteria of the gut. Variation in these sugar structures has the potential to alter bacterial colonization, which was underlined by bacterial composition analysis, and thereby greatly modulate gut health.

The new research findings contribute to an understanding of how genetic elements can control the assembly of particular sugar structures, and thereby control bacterial colonization of the gut. This knowledge has the potential to help find alternative approaches to improve gut health in industrial pig production via genetic selection or other means - without today’s massive use of antibiotics.

The PhD degree was completed at the Department of Molecular Biology and Genetics (MBG), Science and Technology, Aarhus University.

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