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Department of Clinical Medicine

Marco Eijken

Opposing actions of rosiglitazone and resveratrol on mineralization in human vascular smooth muscle cells

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

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Opposing actions of rosiglitazone and resveratrol on mineralization in human vascular smooth muscle cells. / Bruedigam, Claudia; Eijken, Marco; Koedam, Marijke et al.
I: Journal of Molecular and Cellular Cardiology, Bind 51, Nr. 5, 11.2011, s. 862-71.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Vancouver

Bruedigam C, Eijken M, Koedam M, Chiba H, van Leeuwen JPTM. Opposing actions of rosiglitazone and resveratrol on mineralization in human vascular smooth muscle cells. Journal of Molecular and Cellular Cardiology. 2011 nov.;51(5):862-71. doi: 10.1016/j.yjmcc.2011.07.020

Author

Bruedigam, Claudia ; Eijken, Marco ; Koedam, Marijke et al. / Opposing actions of rosiglitazone and resveratrol on mineralization in human vascular smooth muscle cells. I: Journal of Molecular and Cellular Cardiology. 2011 ; Bind 51, Nr. 5. s. 862-71.

Bibtex

@article{efbb025249584f3496fb1422f740d67a,

title = "Opposing actions of rosiglitazone and resveratrol on mineralization in human vascular smooth muscle cells",

abstract = "Arteriosclerotic vascular disease is a major cardiac health problem in westernized countries and the primary cause of mortality in diabetic patients. Recent data have raised serious safety concerns with the antidiabetic rosiglitazone, a thiazolidinedione with peroxisome proliferator-activated receptor γ (PPAR-γ) agonistic activity, in regard to cardiovascular risks. A common feature of atherosclerosis is vascular mineralization. The latter is formed by vascular smooth muscle cells (VSMC) through complex processes that are similar to mineralization in bone. The aim of the current study was to investigate the effect of rosiglitazone on mineralization in cultured human VSMCs. We found that rosiglitazone stimulated mineralization by, at least in part, induction of caspase-dependent apoptosis. Furthermore, rosiglitazone-induced oxidative stress was correlated with stimulated osteoblast-like differentiation of VSMCs. Treatment of rosiglitazone-supplemented VSMC cultures with the caloric restriction mimetic and antioxidant resveratrol diminished rosiglitazone-induced oxidative stress, osteoblast-like differentiation and mineralization. In conclusion, this study reveals novel insights into the relationship of rosiglitazone and cardiovascular events by providing a model that links rosiglitazone-induced osteoblast-like differentiation, oxidative stress and apoptosis with mineralization in VSMCs. In addition, we position resveratrol in this model acting to reduce rosiglitazone-induced oxidative stress, osteoblast-like VSMC differentiation and mineralization.",

keywords = "Apoptosis/drug effects, Atherosclerosis/drug therapy, Caspases/genetics, Cell Differentiation/drug effects, Cells, Cultured, Diabetes Mellitus/drug therapy, Humans, Hypoglycemic Agents/adverse effects, Muscle, Smooth, Vascular/cytology, Myocytes, Smooth Muscle/cytology, Oxidative Stress/drug effects, Resveratrol, Rosiglitazone, Signal Transduction/drug effects, Stilbenes/pharmacology, Thiazolidinediones/adverse effects, Up-Regulation",

author = "Claudia Bruedigam and Marco Eijken and Marijke Koedam and Hideki Chiba and {van Leeuwen}, {Johannes P T M}",

year = "2011",

month = nov,

doi = "10.1016/j.yjmcc.2011.07.020",

language = "English",

volume = "51",

pages = "862--71",

journal = "Journal of Molecular and Cellular Cardiology",

issn = "0022-2828",

publisher = "Academic Press",

number = "5",

}

RIS

TY - JOUR

T1 - Opposing actions of rosiglitazone and resveratrol on mineralization in human vascular smooth muscle cells

AU - Bruedigam, Claudia

AU - Eijken, Marco

AU - Koedam, Marijke

AU - Chiba, Hideki

AU - van Leeuwen, Johannes P T M

PY - 2011/11

Y1 - 2011/11

N2 - Arteriosclerotic vascular disease is a major cardiac health problem in westernized countries and the primary cause of mortality in diabetic patients. Recent data have raised serious safety concerns with the antidiabetic rosiglitazone, a thiazolidinedione with peroxisome proliferator-activated receptor γ (PPAR-γ) agonistic activity, in regard to cardiovascular risks. A common feature of atherosclerosis is vascular mineralization. The latter is formed by vascular smooth muscle cells (VSMC) through complex processes that are similar to mineralization in bone. The aim of the current study was to investigate the effect of rosiglitazone on mineralization in cultured human VSMCs. We found that rosiglitazone stimulated mineralization by, at least in part, induction of caspase-dependent apoptosis. Furthermore, rosiglitazone-induced oxidative stress was correlated with stimulated osteoblast-like differentiation of VSMCs. Treatment of rosiglitazone-supplemented VSMC cultures with the caloric restriction mimetic and antioxidant resveratrol diminished rosiglitazone-induced oxidative stress, osteoblast-like differentiation and mineralization. In conclusion, this study reveals novel insights into the relationship of rosiglitazone and cardiovascular events by providing a model that links rosiglitazone-induced osteoblast-like differentiation, oxidative stress and apoptosis with mineralization in VSMCs. In addition, we position resveratrol in this model acting to reduce rosiglitazone-induced oxidative stress, osteoblast-like VSMC differentiation and mineralization.

AB - Arteriosclerotic vascular disease is a major cardiac health problem in westernized countries and the primary cause of mortality in diabetic patients. Recent data have raised serious safety concerns with the antidiabetic rosiglitazone, a thiazolidinedione with peroxisome proliferator-activated receptor γ (PPAR-γ) agonistic activity, in regard to cardiovascular risks. A common feature of atherosclerosis is vascular mineralization. The latter is formed by vascular smooth muscle cells (VSMC) through complex processes that are similar to mineralization in bone. The aim of the current study was to investigate the effect of rosiglitazone on mineralization in cultured human VSMCs. We found that rosiglitazone stimulated mineralization by, at least in part, induction of caspase-dependent apoptosis. Furthermore, rosiglitazone-induced oxidative stress was correlated with stimulated osteoblast-like differentiation of VSMCs. Treatment of rosiglitazone-supplemented VSMC cultures with the caloric restriction mimetic and antioxidant resveratrol diminished rosiglitazone-induced oxidative stress, osteoblast-like differentiation and mineralization. In conclusion, this study reveals novel insights into the relationship of rosiglitazone and cardiovascular events by providing a model that links rosiglitazone-induced osteoblast-like differentiation, oxidative stress and apoptosis with mineralization in VSMCs. In addition, we position resveratrol in this model acting to reduce rosiglitazone-induced oxidative stress, osteoblast-like VSMC differentiation and mineralization.

KW - Apoptosis/drug effects

KW - Atherosclerosis/drug therapy

KW - Caspases/genetics

KW - Cell Differentiation/drug effects

KW - Cells, Cultured

KW - Diabetes Mellitus/drug therapy

KW - Humans

KW - Hypoglycemic Agents/adverse effects

KW - Muscle, Smooth, Vascular/cytology

KW - Myocytes, Smooth Muscle/cytology

KW - Oxidative Stress/drug effects

KW - Resveratrol

KW - Rosiglitazone

KW - Signal Transduction/drug effects

KW - Stilbenes/pharmacology

KW - Thiazolidinediones/adverse effects

KW - Up-Regulation

U2 - 10.1016/j.yjmcc.2011.07.020

DO - 10.1016/j.yjmcc.2011.07.020

M3 - Journal article

C2 - 21816156

VL - 51

SP - 862

EP - 871

JO - Journal of Molecular and Cellular Cardiology

JF - Journal of Molecular and Cellular Cardiology

SN - 0022-2828

IS - 5

ER -