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Forlagets udgivne version
Forlagets udgivne version
Inflammation resulting from ischaemia/reperfusion injury can cause kidney graft dysfunction, increase the risk of delayed graft function and possibly reduce long-term graft survival. Remote ischaemic conditioning may protect against ischaemia/reperfusion injury and mitigate the immunological response to the graft. We investigated the immunological effects of remote ischaemic conditioning on kidney transplantation from deceased donors in the randomized CONTEXT study. Three circulating dendritic cell (DC) subtypes identified in peripheral blood from kidney transplant recipients [myeloid DCs, plasmacytoid DCs and immunoglobulin-like transcript (ILT)3 + DCs] were measured at baseline, days 1, 3 and 5 and 1 and 3 months after transplantation. We also quantified 21 cytokines at baseline, days 1 and 5 and 3 months after transplantation. Neither DC counts nor cytokine levels differed between patients receiving remote ischaemic conditioning and controls; however, several parameters exhibited dynamic and parallel alterations in the two groups over time, reflecting the immunological response to the kidney transplantation and immunosuppression.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Clinical and Experimental Immunology |
| Vol/bind | 206 |
| Nummer | 2 |
| Sider (fra-til) | 226-236 |
| Antal sider | 11 |
| ISSN | 0964-2536 |
| DOI | |
| Status | Udgivet - nov. 2021 |
Funding Information:
This study was funded by the following: Nyreforeningen (the Danish Kidney Patient Association); Institute of Clinical Medicine– Aarhus University; the Lundbeck Foundation, The Danish Council for Independent Research Medical Sciences; the Novo Nordic Foundation; the Danish Nephrology Society; the Swedish Medical Association; A. P. Møller og hustru Chastine Mc‐Kinney Møllers Fond til Almene Formaal; Aarhus University Hospital; and Aarhus University. The authors acknowledge additional members of the CONTEXT study group (G. J. Nieuwenhuijs‐Moeke, Department of Anaesthesiology, University Center Groningen, the Netherlands and F. J. M. F. Dor, Division of HPB and Transplant Surgery, Department of Surgery, Erasmus MC, University Medical Center, Rotterdam, the Netherlands) for the collection and preparation of patient samples included in this study.
Funding Information:
This study was funded by the following: Nyreforeningen (the Danish Kidney Patient Association); Institute of Clinical Medicine– Aarhus University; the Lundbeck Foundation, The Danish Council for Independent Research Medical Sciences; the Novo Nordic Foundation; the Danish Nephrology Society; the Swedish Medical Association; A. P. Møller og hustru Chastine Mc-Kinney Møllers Fond til Almene Formaal; Aarhus University Hospital; and Aarhus University. The authors acknowledge additional members of the CONTEXT study group (G. J. Nieuwenhuijs-Moeke, Department of Anaesthesiology, University Center Groningen, the Netherlands and F. J. M. F. Dor, Division of HPB and Transplant Surgery, Department of Surgery, Erasmus MC, University Medical Center, Rotterdam, the Netherlands) for the collection and preparation of patient samples included in this study.
Publisher Copyright:
© 2021 British Society for Immunology.
© 2021 British Society for Immunology.
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