Institut for Biomedicin

Marco Capogna

Hippocampal Theta Input to the Amygdala Shapes Feedforward Inhibition to Gate Heterosynaptic Plasticity

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  • Michaël Bazelot, MRC Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK.
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  • Marco Bocchio, MRC Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK.
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  • Yu Kasugai, Department of Pharmacology, Innsbruck Medical University, Peter Mayr Straße 1a, 6020 Innsbruck, Austria.
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  • David Fischer, Department of Pharmacology, Innsbruck Medical University, Peter Mayr Straße 1a, 6020 Innsbruck, Austria.
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  • Paul D Dodson, MRC Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK.
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  • Francesco Ferraguti, Department of Pharmacology, Innsbruck Medical University, Peter Mayr Straße 1a, 6020 Innsbruck, Austria.
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  • Marco Capogna

The dynamic interactions between hippocampus and amygdala are critical for emotional memory. Theta synchrony between these structures occurs during fear memory retrieval and may facilitate synaptic plasticity, but the cellular mechanisms are unknown. We report that interneurons of the mouse basal amygdala are activated during theta network activity or optogenetic stimulation of ventral CA1 pyramidal cell axons, whereas principal neurons are inhibited. Interneurons provide feedforward inhibition that transiently hyperpolarizes principal neurons. However, synaptic inhibition attenuates during theta frequency stimulation of ventral CA1 fibers, and this broadens excitatory postsynaptic potentials. These effects are mediated by GABAB receptors and change in the Cl(-) driving force. Pairing theta frequency stimulation of ventral CA1 fibers with coincident stimuli of the lateral amygdala induces long-term potentiation of lateral-basal amygdala excitatory synapses. Hence, feedforward inhibition, known to enforce temporal fidelity of excitatory inputs, dominates hippocampus-amygdala interactions to gate heterosynaptic plasticity. VIDEO ABSTRACT.

OriginalsprogEngelsk
TidsskriftNeuron
Vol/bind87
Nummer6
Sider (fra-til)1290-1303
Antal sider14
ISSN0896-6273
DOI
StatusUdgivet - 23 sep. 2015
Eksternt udgivetJa

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