Institut for Biomedicin

Marco Capogna

Effects of dopamine, D-1 and D-2 dopaminergic agonists on the excitability of hippocampal CA1 pyramidal cells in guinea pig

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  • N Berretta, Department of Physiology and Biochemistry G. Moruzzi, University of Pisa, Italy.
  • ,
  • F Berton
  • ,
  • R Bianchi
  • ,
  • M Capogna
  • W Francesconi
  • ,
  • M Brunelli

In hippocampal pyramidal cells (HPCs), Dopamine (DA) application (1 microM) produced, in 50% of recorded cells, an hyperpolarization of the resting membrane potential (r.m.p.) and an increase of the afterhyperpolarization (AHP) amplitude and duration in 79% of recorded cells. DA-induced effects on both the r.m.p. and AHP were mimicked by bath application of a D-1 selective agonist, SKF 38393 (20 microM). In addition, we have observed that a D-1 selective antagonist such as SCH 23390 (1 microM) abolished the action of both DA and SKF 38393. In contrast, the activation of D-2 receptors through LY 171555 (10 microns) produced, in 50% of cells, a depolarization of the r.m.p. and a depression of the AHP in 67% of recorded cells. These results suggest that the effects observed in hippocampal pyramidal neurons after DA application of micromolar concentration are mediated by D-1 subtype of receptors.

TidsskriftExperimental Brain Research
Sider (fra-til)124-30
Antal sider7
StatusUdgivet - 1990

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