Mads Jensen

Modulation of Social Influence by Methylphenidate

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Modulation of Social Influence by Methylphenidate. / Campbell-Meiklejohn, Daniel; Simonsen, Arndis; Jensen, Mads; Wohlert, Victoria; Gjerløff, Trine; Scheel-Kruger, Jørgen; Møller, Arne; Frith, Chris D; Roepstorff, Andreas.

I: Neuropsychopharmacology, 2012.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Campbell-Meiklejohn, D, Simonsen, A, Jensen, M, Wohlert, V, Gjerløff, T, Scheel-Kruger, J, Møller, A, Frith, CD & Roepstorff, A 2012, 'Modulation of Social Influence by Methylphenidate', Neuropsychopharmacology. https://doi.org/10.1038/npp.2011.337

APA

Campbell-Meiklejohn, D., Simonsen, A., Jensen, M., Wohlert, V., Gjerløff, T., Scheel-Kruger, J., Møller, A., Frith, C. D., & Roepstorff, A. (2012). Modulation of Social Influence by Methylphenidate. Neuropsychopharmacology. https://doi.org/10.1038/npp.2011.337

CBE

Campbell-Meiklejohn D, Simonsen A, Jensen M, Wohlert V, Gjerløff T, Scheel-Kruger J, Møller A, Frith CD, Roepstorff A. 2012. Modulation of Social Influence by Methylphenidate. Neuropsychopharmacology. https://doi.org/10.1038/npp.2011.337

MLA

Campbell-Meiklejohn, Daniel o.a.. "Modulation of Social Influence by Methylphenidate". Neuropsychopharmacology. 2012. https://doi.org/10.1038/npp.2011.337

Vancouver

Campbell-Meiklejohn D, Simonsen A, Jensen M, Wohlert V, Gjerløff T, Scheel-Kruger J o.a. Modulation of Social Influence by Methylphenidate. Neuropsychopharmacology. 2012. https://doi.org/10.1038/npp.2011.337

Author

Campbell-Meiklejohn, Daniel ; Simonsen, Arndis ; Jensen, Mads ; Wohlert, Victoria ; Gjerløff, Trine ; Scheel-Kruger, Jørgen ; Møller, Arne ; Frith, Chris D ; Roepstorff, Andreas. / Modulation of Social Influence by Methylphenidate. I: Neuropsychopharmacology. 2012.

Bibtex

@article{473df770a8164cc7b1d77cfd0ee2e26a,
title = "Modulation of Social Influence by Methylphenidate",
abstract = "The ability to infer value from the reactions of other people is a common and essential ability with a poorly understood neurobiology. Commonly, social learning matches one's values and behavior to what is perceived as normal for one's social group. This is known as conformity. Conformity of value correlates with neural activity shared by cognitions that depend on optimum catecholamine levels, but catecholamine involvement in conformity has not been tested empirically. Methylphenidate (MPH) is an indirect dopamine and noradrenalin agonist, commonly used for the treatment of attention-deficit hyperactivity disorder for which it reduces undesirable behavior as evaluated by peers and authority figures, indicative of increased conformity. We hypothesized that MPH might increase conformity of value. In all, 38 healthy adult females received either a single oral 20 mg dose of MPH or placebo (PL). Each subject rated 153 faces for trustworthiness followed immediately by the face's mean rating from a group of peers. After 30 min and a 2-back continuous-performance working-memory task, subjects were unexpectedly asked to rate all the faces again. Both the groups tended to change their ratings towards the social norm. The MPH group exhibited twice the conformity effect of the PL group following moderate social conflict, but this did not occur following large conflicts. This suggests that MPH might enhance signals that would otherwise be too weak to evoke conformity. MPH did not affect 2-back performance. We provide a new working hypothesis of a neurocognitive mechanism by which MPH reduces socially disruptive behavior and provides novel evidence of catecholamine mediation of social learning.Neuropsychopharmacology advance online publication, 8 February 2012; doi:10.1038/npp.2011.337.",
author = "Daniel Campbell-Meiklejohn and Arndis Simonsen and Mads Jensen and Victoria Wohlert and Trine Gjerl{\o}ff and J{\o}rgen Scheel-Kruger and Arne M{\o}ller and Frith, {Chris D} and Andreas Roepstorff",
year = "2012",
doi = "10.1038/npp.2011.337",
language = "English",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Modulation of Social Influence by Methylphenidate

AU - Campbell-Meiklejohn, Daniel

AU - Simonsen, Arndis

AU - Jensen, Mads

AU - Wohlert, Victoria

AU - Gjerløff, Trine

AU - Scheel-Kruger, Jørgen

AU - Møller, Arne

AU - Frith, Chris D

AU - Roepstorff, Andreas

PY - 2012

Y1 - 2012

N2 - The ability to infer value from the reactions of other people is a common and essential ability with a poorly understood neurobiology. Commonly, social learning matches one's values and behavior to what is perceived as normal for one's social group. This is known as conformity. Conformity of value correlates with neural activity shared by cognitions that depend on optimum catecholamine levels, but catecholamine involvement in conformity has not been tested empirically. Methylphenidate (MPH) is an indirect dopamine and noradrenalin agonist, commonly used for the treatment of attention-deficit hyperactivity disorder for which it reduces undesirable behavior as evaluated by peers and authority figures, indicative of increased conformity. We hypothesized that MPH might increase conformity of value. In all, 38 healthy adult females received either a single oral 20 mg dose of MPH or placebo (PL). Each subject rated 153 faces for trustworthiness followed immediately by the face's mean rating from a group of peers. After 30 min and a 2-back continuous-performance working-memory task, subjects were unexpectedly asked to rate all the faces again. Both the groups tended to change their ratings towards the social norm. The MPH group exhibited twice the conformity effect of the PL group following moderate social conflict, but this did not occur following large conflicts. This suggests that MPH might enhance signals that would otherwise be too weak to evoke conformity. MPH did not affect 2-back performance. We provide a new working hypothesis of a neurocognitive mechanism by which MPH reduces socially disruptive behavior and provides novel evidence of catecholamine mediation of social learning.Neuropsychopharmacology advance online publication, 8 February 2012; doi:10.1038/npp.2011.337.

AB - The ability to infer value from the reactions of other people is a common and essential ability with a poorly understood neurobiology. Commonly, social learning matches one's values and behavior to what is perceived as normal for one's social group. This is known as conformity. Conformity of value correlates with neural activity shared by cognitions that depend on optimum catecholamine levels, but catecholamine involvement in conformity has not been tested empirically. Methylphenidate (MPH) is an indirect dopamine and noradrenalin agonist, commonly used for the treatment of attention-deficit hyperactivity disorder for which it reduces undesirable behavior as evaluated by peers and authority figures, indicative of increased conformity. We hypothesized that MPH might increase conformity of value. In all, 38 healthy adult females received either a single oral 20 mg dose of MPH or placebo (PL). Each subject rated 153 faces for trustworthiness followed immediately by the face's mean rating from a group of peers. After 30 min and a 2-back continuous-performance working-memory task, subjects were unexpectedly asked to rate all the faces again. Both the groups tended to change their ratings towards the social norm. The MPH group exhibited twice the conformity effect of the PL group following moderate social conflict, but this did not occur following large conflicts. This suggests that MPH might enhance signals that would otherwise be too weak to evoke conformity. MPH did not affect 2-back performance. We provide a new working hypothesis of a neurocognitive mechanism by which MPH reduces socially disruptive behavior and provides novel evidence of catecholamine mediation of social learning.Neuropsychopharmacology advance online publication, 8 February 2012; doi:10.1038/npp.2011.337.

U2 - 10.1038/npp.2011.337

DO - 10.1038/npp.2011.337

M3 - Journal article

C2 - 22318197

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

SN - 0893-133X

ER -