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Luca Schmermund

Ph.d.-studerende

PERSONAL INFORMATION

AddressWildunger Landstrasse 40, D-34497 Korbach
Date of birth14th of April, 1993
Place of birthD-34497 Korbach
NationalityGerman
00491607833412 | lucaleo@online.de

EDUCATION

02/2018-Ph.D, ITN PhotoBioCat, University of Graz
10/2015 - 09/2017Chemistry M.Sc., (final grade 0.9), Philipps-University Marburg
10/2012 - 08/2015Chemistry B.Sc., (final grade 1.4), Philipps-University Marburg
2003-2012Abitur (equivalent to A-level, final grade 1.4), Alte Landesschule Korbach

WORK EXPERIENCES

07/2018 - 08/2018Research stay at GlaxoSmithKline, Research and Development, Photocatalysis and Biocatalysis group.
03/2017 - 09/2017Master thesis, Philipps-University Marburg, Department of Chemical Biology (“Synthesis of 12-epi-hapalindole C derivatives to investigate the substrate scope of WelO15 halogenase variants”, working group of Dr. S. HOEBENREICH). This research work has shown a first step towards the use of non-heme iron-dependent halogenases as biocatalysts that chlorinate small freestanding molecules.
2015-2017Scientific internships, Philipps-University Marburg In the following fields: · Chemical Biology (Protein engineering, bioactivity assays and investigation of the substrate scope of Fe(II)/α-KG-dependent halogenase Hw-WelO15, working group of Dr. S. HOEBENREICH). · Biochemistry (Methods of biochemistry and molecular biology, characterization of CFEM-domains and the two fungal cell wall proteins Ecm33 and Pst1, Master internship and working group of Prof. Dr. L.O. ESSENMedical Chemistry (Synthesis and characterization of inhibitors of the WNV-protease using boronic acids as a basic structure, working group of Prof. Dr. T. STEINMETZER). · Organic Chemistry (Nickel-catalysed isomerization and syn-selective allylboration reactions, synthesis of unnatural amino acids for solid-phase peptide synthesis, working group of Prof. Dr. G. HILT and Prof. Dr. A. GEYER).).
05/2015 - 07/2015Bachelor thesis, Philipps-University Marburg, Department of Biochemistry (“Investigations of DNA-uptake in Bacillus subtilis", working group of Prof. Dr. P.L. GRAUMANN).

Skills and expertise

Molecular cloning, protein engineering and directed evolution (error prone PCR, saturation mutagenesis), heterologous expression and protein purification (size exclusion purification, affinity chromatography, heat purification), biocatalysis, enzymatic assays, enzyme kinetics.
Organic chemistry including retrosynthetic analysis, asymmetric synthesis, transition metal catalysis and working under exclusion of water and oxygen, solid-phase peptide synthesis.
NMR-spectroscopy including 2D-NMR (HSQC, HMBC, COSY, NOESY), GC, HPLC, FPLC, mass spectrometry, CD-spectroscopy, fluorescence microscopy.
MS Office, ChemBio Office, Chimera, YASARA, QtiPlot, TopSpin, SnapGene

LANGUAGE SKILLS

GermanMother tongue
EnglishFluent (C1)