Lise Wogensen

The effects of adenocaine (adenosine and lidocaine) on early post-resuscitation cardiac and neurological dysfunction in a porcine model of cardiac arrest

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Asger Granfeldt
  • Weiwei Shi
  • ,
  • Susan L Schmarkey
  • ,
  • Rong Jiang
  • ,
  • C Collin Bone
  • ,
  • J Mark Cline
  • ,
  • Lise Wogensen
  • Geoffrey P Dobson
  • ,
  • Else Tønnesen, Danmark
  • Jakob Vinten-Johansen
Return of spontaneous circulation (ROSC) elicits ischaemia/reperfusion injury and myocardial dysfunction. The combination of adenosine and lidocaine (AL, adenocaine) has been shown to (1) inhibit neutrophil inflammatory activation and (2) improve left ventricular function after ischaemia. We hypothesized that resuscitation with adenocaine during early moments of cardiopulmonary resuscitation (CPR) attenuates leucocyte oxidant generation and myocardial dysfunction.
OriginalsprogEngelsk
TidsskriftResuscitation
Vol/bind84
Nummer11
Sider (fra-til)1611-8
Antal sider8
ISSN0300-9572
DOI
StatusUdgivet - nov. 2013

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