Lise Wogensen

Interleukin-1 potentiates glucose stimulated insulin release in the isolated perfused pancreas

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  • L D Wogensen
  • T Mandrup-Poulsen
  • ,
  • H Markholst, Danmark
  • J Mølvig
  • ,
  • A Lernmark, Danmark
  • J J Holst
  • ,
  • C A Dinarello
  • ,
  • J Nerup

The acute effects of recombinant human interleukin-1 beta (rIL-1) on basal and glucose-stimulated insulin release were investigated in the isolated perfused pancreas. At a concentration of 20 micrograms/l rIL-1 had no effect on basal insulin release, but increased the total amount of insulin released during first and second phase insulin release in response to 20 mmol/l D-glucose in the rat pancreas (P less than 0.05). In addition, 26 micrograms/l of rIL-1 potentiated insulin release in response to square wave infusions of stimulatory concentrations of glucose (11 mmol/l) in the porcine pancreas. We hypothesize that IL-1 in the systemic circulation may affect B cell function in vivo.

OriginalsprogEngelsk
TidsskriftActa Endocrinologica
Vol/bind117
Nummer3
Sider (fra-til)302-306
Antal sider5
ISSN0001-5598
StatusUdgivet - mar. 1988

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