Lise Wogensen

High plasma concentrations of prorenin in a transgenic animal model of nephropathy with overexpression of transforming growth factor-beta1 in the kidneys

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High plasma concentrations of prorenin in a transgenic animal model of nephropathy with overexpression of transforming growth factor-beta1 in the kidneys. / Krag, S; Nielsen, A H; Wogensen, L.

I: Clinical and Experimental Pharmacology & Physiology (Online), Bind 27, Nr. 9, 09.2000, s. 724-6.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Krag, S, Nielsen, AH & Wogensen, L 2000, 'High plasma concentrations of prorenin in a transgenic animal model of nephropathy with overexpression of transforming growth factor-beta1 in the kidneys', Clinical and Experimental Pharmacology & Physiology (Online), bind 27, nr. 9, s. 724-6.

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Krag, S ; Nielsen, A H ; Wogensen, L. / High plasma concentrations of prorenin in a transgenic animal model of nephropathy with overexpression of transforming growth factor-beta1 in the kidneys. I: Clinical and Experimental Pharmacology & Physiology (Online). 2000 ; Bind 27, Nr. 9. s. 724-6.

Bibtex

@article{a37fad8f80cb4f55bbd44d95eb791212,
title = "High plasma concentrations of prorenin in a transgenic animal model of nephropathy with overexpression of transforming growth factor-beta1 in the kidneys",
abstract = "1. Plasma concentrations of prorenin were determined in a transgenic animal model of nephropathy induced by overexpression of transforming growth factor (TGF)-beta1 in the juxtaglomerular apparatus. 2. In both female and male mice, plasma concentrations of prorenin were higher in transgenic than in non-transgenic animals. In sexually mature mice, plasma prorenin concentrations were higher in males than in females in both transgenic and non-transgenic animals in accordance with a sexual dimorphism of the plasma concentration of prorenin. 3. The results indicate that TGF-beta1-like androgens increase prorenin secretion in the kidneys and may explain the increased plasma prorenin concentrations in patients with diabetic nephropathy.",
keywords = "Aging, Animals, Diabetic Neuropathies, Disease Models, Animal, Enzyme Precursors, Female, Juxtaglomerular Apparatus, Male, Mice, Mice, Inbred BALB C, Mice, Transgenic, Renin, Transforming Growth Factor beta, Transforming Growth Factor beta1",
author = "S Krag and Nielsen, {A H} and L Wogensen",
year = "2000",
month = sep,
language = "English",
volume = "27",
pages = "724--6",
journal = "Clinical and Experimental Pharmacology & Physiology (Online)",
issn = "1440-1681",
publisher = "Wiley-Blackwell Publishing Asia",
number = "9",

}

RIS

TY - JOUR

T1 - High plasma concentrations of prorenin in a transgenic animal model of nephropathy with overexpression of transforming growth factor-beta1 in the kidneys

AU - Krag, S

AU - Nielsen, A H

AU - Wogensen, L

PY - 2000/9

Y1 - 2000/9

N2 - 1. Plasma concentrations of prorenin were determined in a transgenic animal model of nephropathy induced by overexpression of transforming growth factor (TGF)-beta1 in the juxtaglomerular apparatus. 2. In both female and male mice, plasma concentrations of prorenin were higher in transgenic than in non-transgenic animals. In sexually mature mice, plasma prorenin concentrations were higher in males than in females in both transgenic and non-transgenic animals in accordance with a sexual dimorphism of the plasma concentration of prorenin. 3. The results indicate that TGF-beta1-like androgens increase prorenin secretion in the kidneys and may explain the increased plasma prorenin concentrations in patients with diabetic nephropathy.

AB - 1. Plasma concentrations of prorenin were determined in a transgenic animal model of nephropathy induced by overexpression of transforming growth factor (TGF)-beta1 in the juxtaglomerular apparatus. 2. In both female and male mice, plasma concentrations of prorenin were higher in transgenic than in non-transgenic animals. In sexually mature mice, plasma prorenin concentrations were higher in males than in females in both transgenic and non-transgenic animals in accordance with a sexual dimorphism of the plasma concentration of prorenin. 3. The results indicate that TGF-beta1-like androgens increase prorenin secretion in the kidneys and may explain the increased plasma prorenin concentrations in patients with diabetic nephropathy.

KW - Aging

KW - Animals

KW - Diabetic Neuropathies

KW - Disease Models, Animal

KW - Enzyme Precursors

KW - Female

KW - Juxtaglomerular Apparatus

KW - Male

KW - Mice

KW - Mice, Inbred BALB C

KW - Mice, Transgenic

KW - Renin

KW - Transforming Growth Factor beta

KW - Transforming Growth Factor beta1

M3 - Journal article

C2 - 10972540

VL - 27

SP - 724

EP - 726

JO - Clinical and Experimental Pharmacology & Physiology (Online)

JF - Clinical and Experimental Pharmacology & Physiology (Online)

SN - 1440-1681

IS - 9

ER -