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Leslie Foldager

Associations between intelligence, verbal working memory and processing speed in parents with schizophrenia or bipolar disorder and their 7-year old offspring

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisKonferenceabstrakt i tidsskriftForskningpeer review

  • Aja Neergaard Greve
  • Jens Richardt M. Jepsen, Univ Copenhagen, University of Copenhagen, Ctr Clin Intervent & Neuropsychiat Schizophrenia, CINS, Mental Hlth Ctr,Glostrup, Danmark
  • Erik Lykke Mortensen, Institut for Folkesundhed, Københavns Universitet, Københavns Universitet, Danmark
  • Rudolf Uher, Dalhousie Univ, Dalhousie University, Dept Biol, Canada
  • Lynn Mackenzie, Dalhousie Univ, Dalhousie University, Dept Biol, Canada
  • Leslie Foldager
  • Ditte Lou Langhoff Gantriis
  • Birgitte Klee Burton, Mental Hlth Serv Capital Reg, Child & Adolescent Mental Hlth Ctr, Danmark
  • Ditte Vestbjerg Ellersgaard, Univ Copenhagen, University of Copenhagen, Res Unit, Mental Hlth Ctr Copenhagen, Danmark
  • Camilla Jerlang Christiani, Copenhagen Univ Hosp, University of Copenhagen, Mental Hlth Ctr Copenhagen, Psychotherapeut Clin Nannasgade, Capital Reg Mental Hlth Serv, Danmark
  • Katrine Søborg Spang, Copenhagen Univ Hosp, University of Copenhagen, Mental Hlth Ctr Copenhagen, Psychotherapeut Clin Nannasgade, Capital Reg Mental Hlth Serv, Danmark
  • Nicoline Hemager, Univ Copenhagen, University of Copenhagen, Child & Adolescent Mental Hlth Ctr, Mental Hlth Serv, Danmark
  • Maria Toft Henriksen, Aarhus University Hospital, Risskov, Danmark
  • Kate Kold Zahle
  • ,
  • Henriette Brockdorff Stadsgaard
  • ,
  • Anne A E Thorup, Univ Copenhagen, University of Copenhagen, Res Unit, Mental Hlth Ctr Copenhagen, Danmark
  • Merete Nordentoft, Univ Copenhagen, University of Copenhagen, Res Unit, Mental Hlth Ctr Copenhagen, Danmark
  • Kerstin Plessen, Copenhagen Univ Hosp, University of Copenhagen, Mental Hlth Ctr Copenhagen, Psychotherapeut Clin Nannasgade, Capital Reg Mental Hlth Serv, Danmark
  • Ole Mors
  • Vibeke Fuglsang Bliksted
Background
Neurocognitive phenotypes may contribute to understanding the pathway leading from genes to psychopathology. We aimed to investigate associations of intelligence, processing speed and verbal working memory between parents and offspring in families with schizophrenia, bipolar disorder and controls.

MethodsData are from The Danish High Risk and Resilience Study – VIA7, a population-based nationwide cohort identified through Danish Registries. Participants are 522 children aged 7 with no, one, or two parents with schizophrenia or bipolar disorder and biological parents. Control children were matched to children from the schizophrenia group (age, gender, and municipality). Children at familial risk of bipolar disorder were comparison group. Child assessors were blinded to risk status. Main Outcomes were intelligence measured with Reynolds Intellectual Screening Test (RIST), verbal working memory assessed with letter number sequencing (LNS) and processing speed assessed with Coding (WISC-IV/WAIS-IV).

ResultsWe examined 434 index parents (151 schizophrenia, 100 bipolar disorder and 183 controls, mean (SD) age 39.7 (5.7), 264 (61%) females), 443 co-parents (mean (SD) age 40.1 (5.4), 210 (47%) females) and 489 children (mean (SD) age 7.8 (0.2), 231 (47%) females). Children′s intelligence was associated with index parents’ intelligence (B = 0.40, 95% CI: 0.28;0.52, p < 0.001) and co-parents’ intelligence (B = 0.16, 95% CI: 0.03;0.28, p = 0.012). Children’s processing speed was associated with index parents’ processing speed (B = 0.07, 95% CI: 0.02;0.12, p = 0.007), co-parents’ processing speed (B = 0.09, 95% CI: 0.04;0.15, p < 0.001), group (schizophrenia: B = -1.92, 95% CI: -3.63;-0.21, p = 0.028) and gender of child (male: B = -4.55, 95% CI: -4.98; -2.12, p < 0.001). Children’s working memory was associated with index parents’ LNS score (B=0.25, 95% CI: 0.13;0.37, p < 0.001), co-parents’ working memory (B = 0.23, 95% CI: 0.09;0.37, p = 0.001), group (schizophrenia: B = -1.02, 95% CI: -0.89;-0.16, p = 0.020) and gender of child (male: B = -0.85, 95% CI: -1.60;-0.11, p = 0.025).

DiscussionFindings showed associations of neurocognitive phenotypes between parents and offspring. These associations do not differ markedly between schizophrenia, bipolar disorder and controls.
OriginalsprogEngelsk
TidsskriftSchizophrenia Bulletin
Vol/bind44
NummerSuppl_1
Sider (fra-til)S252-S252
ISSN0586-7614
StatusUdgivet - 1 apr. 2018
Begivenhed6th Biennial Conference of the Schizophrenia-International-Research-Society (SIRS) - Florence, Italien
Varighed: 4 apr. 20188 apr. 2018

Konference

Konference6th Biennial Conference of the Schizophrenia-International-Research-Society (SIRS)
LandItalien
ByFlorence
Periode04/04/201808/04/2018

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