Leslie Foldager

An association between autumn birth and clozapine treatment in patients with schizophrenia: A population-based analysis

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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An association between autumn birth and clozapine treatment in patients with schizophrenia: A population-based analysis. / Sørensen, Holger Jelling; Foldager, Leslie; Røge, Rasmus; Pristed, Sofie Gry; Andreasen, Jesper T.; Nielsen, Jimmi.

I: Nordic Journal of Psychiatry, Bind 68, Nr. 6, 2014, s. 428-432.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Sørensen, HJ, Foldager, L, Røge, R, Pristed, SG, Andreasen, JT & Nielsen, J 2014, 'An association between autumn birth and clozapine treatment in patients with schizophrenia: A population-based analysis', Nordic Journal of Psychiatry, bind 68, nr. 6, s. 428-432. https://doi.org/10.3109/08039488.2013.854408

APA

Sørensen, H. J., Foldager, L., Røge, R., Pristed, S. G., Andreasen, J. T., & Nielsen, J. (2014). An association between autumn birth and clozapine treatment in patients with schizophrenia: A population-based analysis. Nordic Journal of Psychiatry, 68(6), 428-432. https://doi.org/10.3109/08039488.2013.854408

CBE

MLA

Vancouver

Author

Sørensen, Holger Jelling ; Foldager, Leslie ; Røge, Rasmus ; Pristed, Sofie Gry ; Andreasen, Jesper T. ; Nielsen, Jimmi. / An association between autumn birth and clozapine treatment in patients with schizophrenia: A population-based analysis. I: Nordic Journal of Psychiatry. 2014 ; Bind 68, Nr. 6. s. 428-432.

Bibtex

@article{c75a97b032d64040b38fa7facb56db53,
title = "An association between autumn birth and clozapine treatment in patients with schizophrenia: A population-based analysis",
abstract = "Background: Numerous studies on seasonality of birth and schizophrenia risk have been published but it is uncertain whether, among those with schizophrenia, refractory illness exhibits any predilection for birth month. We hypothesized and examined whether a season of birth effect was present in patients with schizophrenia with a history of clozapine treatment. Method: Using record linkage with Danish registers, we examined patients with schizophrenia born between 1950 and 1970, and between 1995 and 2009 and Cox regression analysis was used to examine season of birth in relation to history of clozapine treatment. Results: In a study population corresponding to 60,062 person-years from 5328 individuals with schizophrenia of which 1223 (23{\%}) received at least one clozapine prescription, birth in the autumn (September – November) was associated with clozapine treatment (HR 1.24; 95{\%} CI 1.07 – 1.46) when compared with birth in the spring (March – May). Conclusion: Although replication studies are needed, this is the fi rst evidence from a nationwide study suggesting a possible seasonassociated risk of clozapine treatment in schizophrenia. The reasons for this relationship remain to be further investigated but might be partially explained by early exposures such as winter flu season and low vitamin D levels.",
author = "S{\o}rensen, {Holger Jelling} and Leslie Foldager and Rasmus R{\o}ge and Pristed, {Sofie Gry} and Andreasen, {Jesper T.} and Jimmi Nielsen",
year = "2014",
doi = "10.3109/08039488.2013.854408",
language = "English",
volume = "68",
pages = "428--432",
journal = "Nordic Journal of Psychiatry",
issn = "0803-9488",
publisher = "Taylor & francis",
number = "6",

}

RIS

TY - JOUR

T1 - An association between autumn birth and clozapine treatment in patients with schizophrenia: A population-based analysis

AU - Sørensen, Holger Jelling

AU - Foldager, Leslie

AU - Røge, Rasmus

AU - Pristed, Sofie Gry

AU - Andreasen, Jesper T.

AU - Nielsen, Jimmi

PY - 2014

Y1 - 2014

N2 - Background: Numerous studies on seasonality of birth and schizophrenia risk have been published but it is uncertain whether, among those with schizophrenia, refractory illness exhibits any predilection for birth month. We hypothesized and examined whether a season of birth effect was present in patients with schizophrenia with a history of clozapine treatment. Method: Using record linkage with Danish registers, we examined patients with schizophrenia born between 1950 and 1970, and between 1995 and 2009 and Cox regression analysis was used to examine season of birth in relation to history of clozapine treatment. Results: In a study population corresponding to 60,062 person-years from 5328 individuals with schizophrenia of which 1223 (23%) received at least one clozapine prescription, birth in the autumn (September – November) was associated with clozapine treatment (HR 1.24; 95% CI 1.07 – 1.46) when compared with birth in the spring (March – May). Conclusion: Although replication studies are needed, this is the fi rst evidence from a nationwide study suggesting a possible seasonassociated risk of clozapine treatment in schizophrenia. The reasons for this relationship remain to be further investigated but might be partially explained by early exposures such as winter flu season and low vitamin D levels.

AB - Background: Numerous studies on seasonality of birth and schizophrenia risk have been published but it is uncertain whether, among those with schizophrenia, refractory illness exhibits any predilection for birth month. We hypothesized and examined whether a season of birth effect was present in patients with schizophrenia with a history of clozapine treatment. Method: Using record linkage with Danish registers, we examined patients with schizophrenia born between 1950 and 1970, and between 1995 and 2009 and Cox regression analysis was used to examine season of birth in relation to history of clozapine treatment. Results: In a study population corresponding to 60,062 person-years from 5328 individuals with schizophrenia of which 1223 (23%) received at least one clozapine prescription, birth in the autumn (September – November) was associated with clozapine treatment (HR 1.24; 95% CI 1.07 – 1.46) when compared with birth in the spring (March – May). Conclusion: Although replication studies are needed, this is the fi rst evidence from a nationwide study suggesting a possible seasonassociated risk of clozapine treatment in schizophrenia. The reasons for this relationship remain to be further investigated but might be partially explained by early exposures such as winter flu season and low vitamin D levels.

U2 - 10.3109/08039488.2013.854408

DO - 10.3109/08039488.2013.854408

M3 - Journal article

C2 - 24228775

VL - 68

SP - 428

EP - 432

JO - Nordic Journal of Psychiatry

JF - Nordic Journal of Psychiatry

SN - 0803-9488

IS - 6

ER -