Psykologisk Institut

Lene Vase

The placebo response in myasthenia gravis assessed by quantitative myasthenia gravis score: A meta-analysis

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

The placebo response in myasthenia gravis assessed by quantitative myasthenia gravis score : A meta-analysis. / Frisaldi, Elisa; Shaibani, Aziz; Vollert, Jan; Ferrero, Bruno; Carrino, Roberta; Ibraheem, Hayan Dhamer; Vase, Lene; Benedetti, Fabrizio.

I: Muscle and Nerve, Bind 59, Nr. 6, 2019, s. 671-678.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Frisaldi, E, Shaibani, A, Vollert, J, Ferrero, B, Carrino, R, Ibraheem, HD, Vase, L & Benedetti, F 2019, 'The placebo response in myasthenia gravis assessed by quantitative myasthenia gravis score: A meta-analysis', Muscle and Nerve, bind 59, nr. 6, s. 671-678. https://doi.org/10.1002/mus.26469

APA

Frisaldi, E., Shaibani, A., Vollert, J., Ferrero, B., Carrino, R., Ibraheem, H. D., ... Benedetti, F. (2019). The placebo response in myasthenia gravis assessed by quantitative myasthenia gravis score: A meta-analysis. Muscle and Nerve, 59(6), 671-678. https://doi.org/10.1002/mus.26469

CBE

Frisaldi E, Shaibani A, Vollert J, Ferrero B, Carrino R, Ibraheem HD, Vase L, Benedetti F. 2019. The placebo response in myasthenia gravis assessed by quantitative myasthenia gravis score: A meta-analysis. Muscle and Nerve. 59(6):671-678. https://doi.org/10.1002/mus.26469

MLA

Vancouver

Frisaldi E, Shaibani A, Vollert J, Ferrero B, Carrino R, Ibraheem HD o.a. The placebo response in myasthenia gravis assessed by quantitative myasthenia gravis score: A meta-analysis. Muscle and Nerve. 2019;59(6):671-678. https://doi.org/10.1002/mus.26469

Author

Frisaldi, Elisa ; Shaibani, Aziz ; Vollert, Jan ; Ferrero, Bruno ; Carrino, Roberta ; Ibraheem, Hayan Dhamer ; Vase, Lene ; Benedetti, Fabrizio. / The placebo response in myasthenia gravis assessed by quantitative myasthenia gravis score : A meta-analysis. I: Muscle and Nerve. 2019 ; Bind 59, Nr. 6. s. 671-678.

Bibtex

@article{e0efdf137419414fb24cdfacdd3df05b,
title = "The placebo response in myasthenia gravis assessed by quantitative myasthenia gravis score: A meta-analysis",
abstract = "Introduction: This meta-analysis investigates the placebo response in generalized myasthenia gravis (MG) trials by means of Quantitative Myasthenia Gravis (QMG) scores. Methods: PubMed, Scopus, Web of Science, Cochrane Controlled Trial Register, and EMBASE were searched. QMG score, dropouts rate, adverse events (AEs), and AEs responsible for dropouts were examined, together with treatment moderators. Results: The magnitude of placebo response showed an effect size of 0.24, which was significantly lower than 0.67 of the drug response (P = 0.019). Furthermore, the forest plot revealed that, overall, active treatments showed a significantly higher impact on QMG scores than placebos. Conclusions: Placebo and drug responses in MG trials are small and moderate, respectively. The lack of MG trials with a pure placebo arm or a no-treatment control arm made it impossible to disentangle improvements due to the placebo psychological effect from other effects such as natural history and/or regression to the mean. Muscle Nerve 59:671–678, 2019.",
keywords = "clinical trials, meta-analysis, myasthenia gravis, neuromuscular disorders, placebo effect, placebo response",
author = "Elisa Frisaldi and Aziz Shaibani and Jan Vollert and Bruno Ferrero and Roberta Carrino and Ibraheem, {Hayan Dhamer} and Lene Vase and Fabrizio Benedetti",
year = "2019",
doi = "10.1002/mus.26469",
language = "English",
volume = "59",
pages = "671--678",
journal = "Muscle & Nerve",
issn = "0148-639X",
publisher = "JohnWiley & Sons, Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - The placebo response in myasthenia gravis assessed by quantitative myasthenia gravis score

T2 - A meta-analysis

AU - Frisaldi, Elisa

AU - Shaibani, Aziz

AU - Vollert, Jan

AU - Ferrero, Bruno

AU - Carrino, Roberta

AU - Ibraheem, Hayan Dhamer

AU - Vase, Lene

AU - Benedetti, Fabrizio

PY - 2019

Y1 - 2019

N2 - Introduction: This meta-analysis investigates the placebo response in generalized myasthenia gravis (MG) trials by means of Quantitative Myasthenia Gravis (QMG) scores. Methods: PubMed, Scopus, Web of Science, Cochrane Controlled Trial Register, and EMBASE were searched. QMG score, dropouts rate, adverse events (AEs), and AEs responsible for dropouts were examined, together with treatment moderators. Results: The magnitude of placebo response showed an effect size of 0.24, which was significantly lower than 0.67 of the drug response (P = 0.019). Furthermore, the forest plot revealed that, overall, active treatments showed a significantly higher impact on QMG scores than placebos. Conclusions: Placebo and drug responses in MG trials are small and moderate, respectively. The lack of MG trials with a pure placebo arm or a no-treatment control arm made it impossible to disentangle improvements due to the placebo psychological effect from other effects such as natural history and/or regression to the mean. Muscle Nerve 59:671–678, 2019.

AB - Introduction: This meta-analysis investigates the placebo response in generalized myasthenia gravis (MG) trials by means of Quantitative Myasthenia Gravis (QMG) scores. Methods: PubMed, Scopus, Web of Science, Cochrane Controlled Trial Register, and EMBASE were searched. QMG score, dropouts rate, adverse events (AEs), and AEs responsible for dropouts were examined, together with treatment moderators. Results: The magnitude of placebo response showed an effect size of 0.24, which was significantly lower than 0.67 of the drug response (P = 0.019). Furthermore, the forest plot revealed that, overall, active treatments showed a significantly higher impact on QMG scores than placebos. Conclusions: Placebo and drug responses in MG trials are small and moderate, respectively. The lack of MG trials with a pure placebo arm or a no-treatment control arm made it impossible to disentangle improvements due to the placebo psychological effect from other effects such as natural history and/or regression to the mean. Muscle Nerve 59:671–678, 2019.

KW - clinical trials

KW - meta-analysis

KW - myasthenia gravis

KW - neuromuscular disorders

KW - placebo effect

KW - placebo response

UR - http://www.scopus.com/inward/record.url?scp=85063692827&partnerID=8YFLogxK

U2 - 10.1002/mus.26469

DO - 10.1002/mus.26469

M3 - Journal article

C2 - 30883809

AN - SCOPUS:85063692827

VL - 59

SP - 671

EP - 678

JO - Muscle & Nerve

JF - Muscle & Nerve

SN - 0148-639X

IS - 6

ER -