Psykologisk Institut

Lene Vase

How May Placebo Mechanisms Influence Orofacial Neuropathic Pain?

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How May Placebo Mechanisms Influence Orofacial Neuropathic Pain? / Vase, L.; Baad-Hansen, L.; Pigg, M.

I: Journal of Dental Research, Bind 98, Nr. 8, 2019, s. 861-869.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

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Vase, L. ; Baad-Hansen, L. ; Pigg, M. / How May Placebo Mechanisms Influence Orofacial Neuropathic Pain?. I: Journal of Dental Research. 2019 ; Bind 98, Nr. 8. s. 861-869.

Bibtex

@article{67f1e9adefa843cf875c955f702c92ab,
title = "How May Placebo Mechanisms Influence Orofacial Neuropathic Pain?",
abstract = "The conceptualization of placebo has changed from inactive pills to a detailed understanding of how patients’ perception of receiving a treatment influences pain processing and overall treatment outcome. Large placebo effects were recently demonstrated in chronic neuropathic pain, thereby opening the question of whether placebo effects also apply to orofacial neuropathic pain. In this article, we review the new definitions, magnitude, and social, psychological, neurobiologic, and genetic mechanisms of placebo effects in pain, especially neuropathic pain, to illustrate that placebo effects are not simply response bias but psychoneurobiological phenomena that can be measured at many levels of the neuroaxis. We use this knowledge to carefully illustrate how patients’ perceptions of the treatment, the relationship with the health care provider, and the expectations and emotions toward a treatment can influence test and treatment outcome and potentially skew the results if they are not taken into consideration. Orofacial neuropathic pain is a new research area, and we review the status on definition, diagnosis, mechanisms, and pharmacologic treatment of neuropathic pain after trigeminal nerve injury, as this condition may be especially influenced by placebo factors. Finally, we have a detailed discussion of how knowledge of placebo mechanisms may help improve the understanding, diagnosis, and treatment of orofacial neuropathic pain, and we illustrate pitfalls and opportunities of applying this knowledge to the test of dental treatments.",
keywords = "cognition, facial pain, neuralgia, placebo effect, randomized controlled trial, treatment outcome",
author = "L. Vase and L. Baad-Hansen and M. Pigg",
year = "2019",
doi = "10.1177/0022034519848719",
language = "English",
volume = "98",
pages = "861--869",
journal = "Advances in Dental Research",
issn = "0895-9374",
publisher = "International and American Associations for Dental Research",
number = "8",

}

RIS

TY - JOUR

T1 - How May Placebo Mechanisms Influence Orofacial Neuropathic Pain?

AU - Vase, L.

AU - Baad-Hansen, L.

AU - Pigg, M.

PY - 2019

Y1 - 2019

N2 - The conceptualization of placebo has changed from inactive pills to a detailed understanding of how patients’ perception of receiving a treatment influences pain processing and overall treatment outcome. Large placebo effects were recently demonstrated in chronic neuropathic pain, thereby opening the question of whether placebo effects also apply to orofacial neuropathic pain. In this article, we review the new definitions, magnitude, and social, psychological, neurobiologic, and genetic mechanisms of placebo effects in pain, especially neuropathic pain, to illustrate that placebo effects are not simply response bias but psychoneurobiological phenomena that can be measured at many levels of the neuroaxis. We use this knowledge to carefully illustrate how patients’ perceptions of the treatment, the relationship with the health care provider, and the expectations and emotions toward a treatment can influence test and treatment outcome and potentially skew the results if they are not taken into consideration. Orofacial neuropathic pain is a new research area, and we review the status on definition, diagnosis, mechanisms, and pharmacologic treatment of neuropathic pain after trigeminal nerve injury, as this condition may be especially influenced by placebo factors. Finally, we have a detailed discussion of how knowledge of placebo mechanisms may help improve the understanding, diagnosis, and treatment of orofacial neuropathic pain, and we illustrate pitfalls and opportunities of applying this knowledge to the test of dental treatments.

AB - The conceptualization of placebo has changed from inactive pills to a detailed understanding of how patients’ perception of receiving a treatment influences pain processing and overall treatment outcome. Large placebo effects were recently demonstrated in chronic neuropathic pain, thereby opening the question of whether placebo effects also apply to orofacial neuropathic pain. In this article, we review the new definitions, magnitude, and social, psychological, neurobiologic, and genetic mechanisms of placebo effects in pain, especially neuropathic pain, to illustrate that placebo effects are not simply response bias but psychoneurobiological phenomena that can be measured at many levels of the neuroaxis. We use this knowledge to carefully illustrate how patients’ perceptions of the treatment, the relationship with the health care provider, and the expectations and emotions toward a treatment can influence test and treatment outcome and potentially skew the results if they are not taken into consideration. Orofacial neuropathic pain is a new research area, and we review the status on definition, diagnosis, mechanisms, and pharmacologic treatment of neuropathic pain after trigeminal nerve injury, as this condition may be especially influenced by placebo factors. Finally, we have a detailed discussion of how knowledge of placebo mechanisms may help improve the understanding, diagnosis, and treatment of orofacial neuropathic pain, and we illustrate pitfalls and opportunities of applying this knowledge to the test of dental treatments.

KW - cognition

KW - facial pain

KW - neuralgia

KW - placebo effect

KW - randomized controlled trial

KW - treatment outcome

UR - http://www.scopus.com/inward/record.url?scp=85067826423&partnerID=8YFLogxK

U2 - 10.1177/0022034519848719

DO - 10.1177/0022034519848719

M3 - Review

C2 - 31084512

AN - SCOPUS:85067826423

VL - 98

SP - 861

EP - 869

JO - Advances in Dental Research

JF - Advances in Dental Research

SN - 0895-9374

IS - 8

ER -