Psykologisk Institut

Lene Vase

Can knowledge of Placebo and Nocebo Mechanisms Help Improve Randomized Clinical Trials?

Publikation: Bidrag til bog/antologi/rapport/proceedingBidrag til bog/antologiForskningpeer review

Standard

Can knowledge of Placebo and Nocebo Mechanisms Help Improve Randomized Clinical Trials? / Carlino, Elisa; Vase, Lene.

Neurobiology of the Placebo Effect Part I. red. / Luana Colloca. Cambridge, MA : Academic Press, 2018. s. 329-357 (International Review of Neurobiology, Bind 138).

Publikation: Bidrag til bog/antologi/rapport/proceedingBidrag til bog/antologiForskningpeer review

Harvard

Carlino, E & Vase, L 2018, Can knowledge of Placebo and Nocebo Mechanisms Help Improve Randomized Clinical Trials? i L Colloca (red.), Neurobiology of the Placebo Effect Part I. Academic Press, Cambridge, MA, International Review of Neurobiology, bind 138, s. 329-357. https://doi.org/10.1016/bs.irn.2018.01.012

APA

Carlino, E., & Vase, L. (2018). Can knowledge of Placebo and Nocebo Mechanisms Help Improve Randomized Clinical Trials? I L. Colloca (red.), Neurobiology of the Placebo Effect Part I (s. 329-357). Academic Press. International Review of Neurobiology, Bind. 138 https://doi.org/10.1016/bs.irn.2018.01.012

CBE

Carlino E, Vase L. 2018. Can knowledge of Placebo and Nocebo Mechanisms Help Improve Randomized Clinical Trials?. Colloca L, red. I Neurobiology of the Placebo Effect Part I. Cambridge, MA: Academic Press. s. 329-357. (International Review of Neurobiology, Bind 138). https://doi.org/10.1016/bs.irn.2018.01.012

MLA

Carlino, Elisa og Lene Vase "Can knowledge of Placebo and Nocebo Mechanisms Help Improve Randomized Clinical Trials?". Colloca, Luana (redaktører). Neurobiology of the Placebo Effect Part I. Kapitel 18, Cambridge, MA: Academic Press. (International Review of Neurobiology, Bind 138). 2018, 329-357. https://doi.org/10.1016/bs.irn.2018.01.012

Vancouver

Carlino E, Vase L. Can knowledge of Placebo and Nocebo Mechanisms Help Improve Randomized Clinical Trials? I Colloca L, red., Neurobiology of the Placebo Effect Part I. Cambridge, MA: Academic Press. 2018. s. 329-357. (International Review of Neurobiology, Bind 138). https://doi.org/10.1016/bs.irn.2018.01.012

Author

Carlino, Elisa ; Vase, Lene. / Can knowledge of Placebo and Nocebo Mechanisms Help Improve Randomized Clinical Trials?. Neurobiology of the Placebo Effect Part I. red. / Luana Colloca. Cambridge, MA : Academic Press, 2018. s. 329-357 (International Review of Neurobiology, Bind 138).

Bibtex

@inbook{dcab5f61110c488da114a3d55ab64a35,
title = "Can knowledge of Placebo and Nocebo Mechanisms Help Improve Randomized Clinical Trials?",
abstract = "Over the last decade, there has been a substantial increase in negative results from randomized controlled trials (RCTs), which may be due to an increasing placebo response among other factors. Currently, identification and exclusion of placebo responders from trials are attempted to overcome this problem, but so far the success of these approaches has been limited. At the same time, the placebo-mechanism literature has highlighted how contextual factors, such as patients{\textquoteright} expectations, interfere with the effect of drug administration, leading to a certain degree of uncertainty in RCTs. In this chapter, we review the current challenges of RCTs including the uncertainties of the active arm, the placebo arm, the additivity assumption, and the double-blind procedure. We use the placebo-mechanism literature to debate the strengths and weaknesses of attempts to identify and exclude placebo responders from trials. Finally, we illustrate how insights from the placebo-mechanism literature may point to new ways of improving RCTs.",
keywords = "Design, Expectations, Placebo effect, Placebo response, Randomized controlled trial",
author = "Elisa Carlino and Lene Vase",
year = "2018",
month = jan,
day = "1",
doi = "10.1016/bs.irn.2018.01.012",
language = "English",
isbn = "978-0-12-814325-4",
series = "International Review of Neurobiology",
publisher = "Academic Press",
pages = "329--357",
editor = "Luana Colloca",
booktitle = "Neurobiology of the Placebo Effect Part I",

}

RIS

TY - CHAP

T1 - Can knowledge of Placebo and Nocebo Mechanisms Help Improve Randomized Clinical Trials?

AU - Carlino, Elisa

AU - Vase, Lene

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Over the last decade, there has been a substantial increase in negative results from randomized controlled trials (RCTs), which may be due to an increasing placebo response among other factors. Currently, identification and exclusion of placebo responders from trials are attempted to overcome this problem, but so far the success of these approaches has been limited. At the same time, the placebo-mechanism literature has highlighted how contextual factors, such as patients’ expectations, interfere with the effect of drug administration, leading to a certain degree of uncertainty in RCTs. In this chapter, we review the current challenges of RCTs including the uncertainties of the active arm, the placebo arm, the additivity assumption, and the double-blind procedure. We use the placebo-mechanism literature to debate the strengths and weaknesses of attempts to identify and exclude placebo responders from trials. Finally, we illustrate how insights from the placebo-mechanism literature may point to new ways of improving RCTs.

AB - Over the last decade, there has been a substantial increase in negative results from randomized controlled trials (RCTs), which may be due to an increasing placebo response among other factors. Currently, identification and exclusion of placebo responders from trials are attempted to overcome this problem, but so far the success of these approaches has been limited. At the same time, the placebo-mechanism literature has highlighted how contextual factors, such as patients’ expectations, interfere with the effect of drug administration, leading to a certain degree of uncertainty in RCTs. In this chapter, we review the current challenges of RCTs including the uncertainties of the active arm, the placebo arm, the additivity assumption, and the double-blind procedure. We use the placebo-mechanism literature to debate the strengths and weaknesses of attempts to identify and exclude placebo responders from trials. Finally, we illustrate how insights from the placebo-mechanism literature may point to new ways of improving RCTs.

KW - Design

KW - Expectations

KW - Placebo effect

KW - Placebo response

KW - Randomized controlled trial

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U2 - 10.1016/bs.irn.2018.01.012

DO - 10.1016/bs.irn.2018.01.012

M3 - Book chapter

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AN - SCOPUS:85044132428

SN - 978-0-12-814325-4

T3 - International Review of Neurobiology

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BT - Neurobiology of the Placebo Effect Part I

A2 - Colloca, Luana

PB - Academic Press

CY - Cambridge, MA

ER -