Lea Lykke Braskhøj Lauridsen

Alcohol intake during pregnancy and timing of puberty in sons and daughters: a nationwide cohort study

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Alcohol intake during pregnancy and timing of puberty in sons and daughters : a nationwide cohort study. / Brix, Nis; Lauridsen, Lea L B; Ernst, Andreas; Olsen, Jørn; Henriksen, Tine B; Ramlau-Hansen, Cecilia H.

I: Reproductive toxicology (Elmsford, N.Y.), Bind 91, 2020, s. 35-42.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{148f068c5e3e46ec967d758af205b6e1,
title = "Alcohol intake during pregnancy and timing of puberty in sons and daughters: a nationwide cohort study",
abstract = "We explored whether maternal alcohol intake in early pregnancy is associated with pubertal timing in sons and daughters. In total, 15,819 children, born 2000-2003 within the Danish National Birth Cohort, gave half-yearly, self-reported information on pubertal development (Tanner stages, voice break, first ejaculation, menarche, acne, and axillary hair) from 11 years during 2012-2018. Information on maternal average alcohol intake in first trimester and binge drinking episodes (intake of ≥5 drinks on the same occasion) in first trimester was self-reported by mothers during pregnancy. Average alcohol intake of 5+ weekly drinks in first trimester was not associated with pubertal timing in sons (with no alcohol intake as the reference). A tendency towards earlier pubertal timing was observed in daughters (-2.0 (95% confidence interval: -4.2, 0.3) months) when combining the estimates for all pubertal milestones. Binge drinking was not associated with pubertal timing in neither sons nor daughters.",
keywords = "alcohol, maternal exposure, prenatal exposure delayed effects, puberty, menarche",
author = "Nis Brix and Lauridsen, {Lea L B} and Andreas Ernst and J{\o}rn Olsen and Henriksen, {Tine B} and Ramlau-Hansen, {Cecilia H}",
note = "Copyright {\textcopyright} 2019. Published by Elsevier Inc.",
year = "2020",
doi = "10.1016/j.reprotox.2019.11.003",
language = "English",
volume = "91",
pages = "35--42",
journal = "Reproductive Toxicology",
issn = "0890-6238",
publisher = "Elsevier Inc.",

}

RIS

TY - JOUR

T1 - Alcohol intake during pregnancy and timing of puberty in sons and daughters

T2 - a nationwide cohort study

AU - Brix, Nis

AU - Lauridsen, Lea L B

AU - Ernst, Andreas

AU - Olsen, Jørn

AU - Henriksen, Tine B

AU - Ramlau-Hansen, Cecilia H

N1 - Copyright © 2019. Published by Elsevier Inc.

PY - 2020

Y1 - 2020

N2 - We explored whether maternal alcohol intake in early pregnancy is associated with pubertal timing in sons and daughters. In total, 15,819 children, born 2000-2003 within the Danish National Birth Cohort, gave half-yearly, self-reported information on pubertal development (Tanner stages, voice break, first ejaculation, menarche, acne, and axillary hair) from 11 years during 2012-2018. Information on maternal average alcohol intake in first trimester and binge drinking episodes (intake of ≥5 drinks on the same occasion) in first trimester was self-reported by mothers during pregnancy. Average alcohol intake of 5+ weekly drinks in first trimester was not associated with pubertal timing in sons (with no alcohol intake as the reference). A tendency towards earlier pubertal timing was observed in daughters (-2.0 (95% confidence interval: -4.2, 0.3) months) when combining the estimates for all pubertal milestones. Binge drinking was not associated with pubertal timing in neither sons nor daughters.

AB - We explored whether maternal alcohol intake in early pregnancy is associated with pubertal timing in sons and daughters. In total, 15,819 children, born 2000-2003 within the Danish National Birth Cohort, gave half-yearly, self-reported information on pubertal development (Tanner stages, voice break, first ejaculation, menarche, acne, and axillary hair) from 11 years during 2012-2018. Information on maternal average alcohol intake in first trimester and binge drinking episodes (intake of ≥5 drinks on the same occasion) in first trimester was self-reported by mothers during pregnancy. Average alcohol intake of 5+ weekly drinks in first trimester was not associated with pubertal timing in sons (with no alcohol intake as the reference). A tendency towards earlier pubertal timing was observed in daughters (-2.0 (95% confidence interval: -4.2, 0.3) months) when combining the estimates for all pubertal milestones. Binge drinking was not associated with pubertal timing in neither sons nor daughters.

KW - alcohol

KW - maternal exposure

KW - prenatal exposure delayed effects

KW - puberty

KW - menarche

U2 - 10.1016/j.reprotox.2019.11.003

DO - 10.1016/j.reprotox.2019.11.003

M3 - Journal article

C2 - 31711902

VL - 91

SP - 35

EP - 42

JO - Reproductive Toxicology

JF - Reproductive Toxicology

SN - 0890-6238

ER -