Lars-Erik Holm

Seniorforsker

Personal information:

Lars-Erik Holm
Born 9. July 1961

Address:
Institute of Molecular Biology and Genetics
C.F. Møllers Allé 3
Build. 1130, Office 210
8000 Aarhus C

Email: larserik.holm@mbg.au.dk
Phone: +45 22901463

Positions:

2003Senior Scientist, Institute of Molecular Biology and Genetics, Aarhus University.
1999Senior Scientist, Institute of Molecular Biology and Genetics, Aarhus University.
-Temporary group leader at National Institute of Animal Sciences, Dept. of Animal Physiology and Biochemistry, Section of Biochemical Genetics, Immuno- nad Molecular Genetics including the Cattle bloodtyping laboratory for parentage control acting as service laboratory for the cattle breeders association.
1991Research Scientist, Dept. Animal Physiology and Biochemistry, National Institute of Animal Sciences.

Education:

1999Ph.d. degree in Biology, Institute of Biological Sciences, Aarhus University.
1990Candidate of Science degree in biology. Institute of Genetics and Ecology, Aarhus University.

Area of research:

• Improve understanding of imprinted genes
• Utilize information on genetic variation to understand associations to phenotypes

Major grants:

1997EU; partner in 3-year FP4-FAIR project “Generation of highly informative markers and genetic marker maps of Salmonid fishes - SALMAP”. Total EU budget 1,190,000€.
2009EU; partner, WP leader and member of board in 4-year FP7 project “QUANTOMICS – from sequence to consequence”. AU budget 1,327,000€.
2010FTP; project leader 3-year project “Mining of lethal recessive genetic variation in Danish cattle”. Budget 5,734,000DKR.

Teaching

2018Master course at SDC (the university partnership Denmark-China), Beijing, in Molecular genetics and epigenetics. Subjects: cell cycle and chromosome structure, inheritance patterns and pedigrees, genetic mapping, GWAS.
2017Master course in Bioinformatics analysis of genomics data. Subjects: Databases, annotation genetic variants, GWAS.
2015-17Bachelor course in Molecular genetics. Subjects: DNA variation and epigenetics.

Scientific summary:

My research interest is in improving the understanding of inheritance of genes with a different inheritance than the normal equal contributions from each of the parents with a focus on imprinted genes which show expression based on parent-of-origin of the transcript. Increasing the knowledge of imprinted genes and their inheritance is primarily addressed using next generation sequencing (NGS) and bioinformatics approaches. I have an additional interest in looking at genetic variation both in specific genes and at the genome-wide level based on NGS data to understand differences between species or races within a species or the evolutionary development of these groups of individuals. This is with the primary goal of increasing the understanding of the relation between specific genetic variants and associated phenotypic traits.


I have participated in several international EU funded projects most recently as workpackage leader (WP on resequencing in cattle and chicken) and member of board in the Quantomics project (IP, FP7) but also in the BovMap (IP, FP3), Salmap (IP, FP4) and EADGENE (CSA-CA, FP7) EU-funded projects. I also act as the contact person for the group to the 1000 bull genomes consortium (http://www.1000bullgenomes.com).

Bibliometric data/References:

• 41 peer-reviewed publications and 55 congress publications (talks or posters)
• 1 patent application
• H-index = 26 (3660 citations) (https://scholar.google.dk/citations?hl=da&user=HjejFgsAAAAJ)

Selected publications

A.C. Bouwman, H.D. Daetwyler, A.J. Chamberlain, C.H. Ponce, M. Sargolzaei, F.S. Schenkel, G. Sahana, A. Govignon-Gion, S. Boitard, M. Dolezal, H. Pausch, R.F. Brøndum, P.J. Bowman, B. Thomsen, B. Guldbrandtsen, M.S. Lund, B. Servin, D.J. Garrick, J. Reecy, J. Vilkki, A. Bagnato, M. Wang, J.L. Hoff, R.D Schnabel, J.F. Taylor, A.A.E. Vinkhuyzen, F. Panitz, C. Bendixen, L.-E. Holm, B. Gredler, C. Hozé, M. Boussaha, M.-P. Sanchez, D. Rocha, A. Capitan, T. Tribout, A. Barbat, P. Croiseau, C. Drögemüller, V. Jagannathan, C. Vander Jagt, J.J. Crowley, Intergenomics Consortium, A. Bieber, D.C. Purfield, D.P. Berry, R. Emmerling, K.-U. Götz, M. Frischknecht, I. Russ, J. Sölkner, C.P. Van Tassell, R. Fries, P. Stothard, R.F. Veerkamp, D. Boichard, M.E. Goddard, B.J. Hayes (2018). Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals. Nature Genetics, 50, 362-367.

H.P. Bertelsen, V.R. Gregersen, N. Poulsen, R.O. Nielsen, A. Das, L.B. Madsen, A.J. Buitenhuis, L.-E. Holm, F. Panitz, L.B. Larsen, C. Bendixen (2016). Detection of genetic variation affecting milk coagulation properties in Danish Holstein cattle by analyses of pooled whole-genome sequences from phenotypically extreme samples (pool-seq). Journal of Animal Science, 94, 1365-1376.

A. Das, F. Panitz, V.R. Gregersen, C. Bendixen, L.-E. Holm (2015). Deep sequencing of Danish Holstein dairy cattle for variant detection and insight into potential loss-of-function variants in protein coding genes. BMC Genomics, 16, 1043.

J. Fadista, B. Thomsen, L.-E. Holm, C. Bendixen (2010): Copy number variation in the bovine genome. BMC Genomics. 11, 284. 

B. Chessa, F. Pereira, F. Arnaud, A. Amorim, F. Goyache, I. Mainland, R.R. Kao, J.M. Pemberton, D. Beraldi, M. Stear, A. Alberti, M. Pittau, L. Iannuzzi, M.H. Banabazi, R. Kazwala, Y.-P. Zhang, J.J. Arranz, B.A. Ali, Z. Wang, M. Uzun, M. Dione, I. Olsaker, L.-E. Holm, U. Saarma, S. Ahmad, N. Marzanov, E. Eythorsdottir, M.J. Holland, P. Ajmone-Marsan, M.W. Bruford, J. Kantanen, T.E. Spencer, M. Palmarini (2009). Revealing the history of domesticated sheep using retrovirus integrations. Science, 324, 532-536.

L. Nicol, S. Bishop, R. Pong-Wong, C. Bendixen, L.-E. Holm, S. Rhind, A. McNeilly (2009). Homozygosity for a single base pair mutation in the oocyte-specific GDF9 gene results in sterility in Thoka sheep. Reproduction, 138, 921-933.