Institut for Biomedicin

Lars Bolund

Imprinted Genes on Chromosome 6 Are Unlikely to Cause Hydatidiform Mole. A Report of Two Cases

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Imprinted Genes on Chromosome 6 Are Unlikely to Cause Hydatidiform Mole. A Report of Two Cases. / Scholz, Nanna Brink; Lund, Helle; Bolund, Lars; Sunde, Lone.

I: Journal of Reproductive Medicine, Bind 60, Nr. 5-6, 02.07.2015, s. 261-4.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

APA

CBE

MLA

Scholz, Nanna Brink o.a.. "Imprinted Genes on Chromosome 6 Are Unlikely to Cause Hydatidiform Mole. A Report of Two Cases". Journal of Reproductive Medicine. 2015, 60(5-6). 261-4.

Vancouver

Author

Scholz, Nanna Brink ; Lund, Helle ; Bolund, Lars ; Sunde, Lone. / Imprinted Genes on Chromosome 6 Are Unlikely to Cause Hydatidiform Mole. A Report of Two Cases. I: Journal of Reproductive Medicine. 2015 ; Bind 60, Nr. 5-6. s. 261-4.

Bibtex

@article{753734bb995b405f8b8df59894019085,
title = "Imprinted Genes on Chromosome 6 Are Unlikely to Cause Hydatidiform Mole. A Report of Two Cases",
abstract = "BACKGROUND: Hydatidiform moles are associated with an excess of paternal genome set(s) or abnormal imprinting of multiple imprinted genes. However, it appears unlikely that all imprinted genes are relevant for the pathogenesis of a hydatidiform mole.CASES: We studied two rare cases of triploid, diandric moles that were tetrasomic for chromosome 6. DNA-marker analysis showed that in one mole the fourth chromosome 6 originated in the father, and in the other mole the fourth chromosome 6 originated in the mother. Histopathologic revision disclosed that both moles were partial moles with no significant difference in the phenotypes.CONCLUSION: It is unlikely that a major gene involved in the pathogenesis of hydatidiform mole, or a major gene involved in determining the severity of the molar phenotype, is located on chromosome 6.",
author = "Scholz, {Nanna Brink} and Helle Lund and Lars Bolund and Lone Sunde",
year = "2015",
month = "7",
day = "2",
language = "English",
volume = "60",
pages = "261--4",
journal = "Journal of Reproductive Medicine",
issn = "0024-7758",
publisher = "Journal of Reproductive Medicine, Inc.",
number = "5-6",

}

RIS

TY - JOUR

T1 - Imprinted Genes on Chromosome 6 Are Unlikely to Cause Hydatidiform Mole. A Report of Two Cases

AU - Scholz, Nanna Brink

AU - Lund, Helle

AU - Bolund, Lars

AU - Sunde, Lone

PY - 2015/7/2

Y1 - 2015/7/2

N2 - BACKGROUND: Hydatidiform moles are associated with an excess of paternal genome set(s) or abnormal imprinting of multiple imprinted genes. However, it appears unlikely that all imprinted genes are relevant for the pathogenesis of a hydatidiform mole.CASES: We studied two rare cases of triploid, diandric moles that were tetrasomic for chromosome 6. DNA-marker analysis showed that in one mole the fourth chromosome 6 originated in the father, and in the other mole the fourth chromosome 6 originated in the mother. Histopathologic revision disclosed that both moles were partial moles with no significant difference in the phenotypes.CONCLUSION: It is unlikely that a major gene involved in the pathogenesis of hydatidiform mole, or a major gene involved in determining the severity of the molar phenotype, is located on chromosome 6.

AB - BACKGROUND: Hydatidiform moles are associated with an excess of paternal genome set(s) or abnormal imprinting of multiple imprinted genes. However, it appears unlikely that all imprinted genes are relevant for the pathogenesis of a hydatidiform mole.CASES: We studied two rare cases of triploid, diandric moles that were tetrasomic for chromosome 6. DNA-marker analysis showed that in one mole the fourth chromosome 6 originated in the father, and in the other mole the fourth chromosome 6 originated in the mother. Histopathologic revision disclosed that both moles were partial moles with no significant difference in the phenotypes.CONCLUSION: It is unlikely that a major gene involved in the pathogenesis of hydatidiform mole, or a major gene involved in determining the severity of the molar phenotype, is located on chromosome 6.

M3 - Journal article

C2 - 26126314

VL - 60

SP - 261

EP - 264

JO - Journal of Reproductive Medicine

JF - Journal of Reproductive Medicine

SN - 0024-7758

IS - 5-6

ER -