Institut for Biomedicin

Lars Bolund

How to classify the oldest old according to their health status: a study on 1160 subjects belonging to 552 90+ Italian sib-ships characterized by familial longevity recruited within the GEHA EU Project

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  • Elisa Cevenini, DIMES - Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy; C.I.G. - Interdepartmental Centre "L. Galvani", University of Bologna, Piazza di Porta San Donato 1, 40126 Bologna, Italy. Electronic address: elisa.cevenini3@unibo.it., Danmark
  • Rodolfo Cotichini, National Centre for Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy; IFC - Institute of Clinical Physiology, CNR, Via G. Moruzzi 1, 56124 Pisa, Italy. Electronic address: rodolfo.cotichini@ifc.cnr.it., Danmark
  • Maria Antonietta Stazi, National Centre for Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address: antonia.stazi@iss.it.
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  • Virgilia Toccaceli, National Centre for Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address: virgilia.toccaceli@iss.it., Danmark
  • Maria Scurti, DIMES - Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy; C.I.G. - Interdepartmental Centre "L. Galvani", University of Bologna, Piazza di Porta San Donato 1, 40126 Bologna, Italy. Electronic address: maria.scurti@unibo.it., Danmark
  • Vincenzo Mari, Italian National Institute of Aging, INRCA, Contrada Muoio Piccolo, 87100 Cosenza, Italy. Electronic address: v.mari@inrca.it., Danmark
  • Maurizio Berardelli, Department of Biology, Ecology and Earth Science, University of Calabria, 87036 Rende, Italy. Electronic address: mberardelli@libero.it., Danmark
  • Giuseppe Passarino, Department of Biology, Ecology and Earth Science, University of Calabria, 87036 Rende, Italy. Electronic address: g.passarino@unical.it.
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  • Bernard Jeune, Syddansk Universitet
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  • Claudio Franceschi, DIMES - Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy; C.I.G. - Interdepartmental Centre "L. Galvani", University of Bologna, Piazza di Porta San Donato 1, 40126 Bologna, Italy. Electronic address: claudio.franceschi@unibo.it.
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  • GEHA Project Consortium
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  • Lars Bolund

The health status of the oldest old, the fastest increasing population segment worldwide, progressively becomes more heterogeneous, and this peculiarity represents a major obstacle to their classification. We compared the effectiveness of four previously proposed criteria (Franceschi et al., 2000; Evert et al., 2003; Gondo et al., 2006; Andersen-Ranberg et al., 2001) in 1160 phenotypically fully characterized Italian siblings of 90 years of age and older (90+, mean age: 93 years; age range: 90-106 years) belonging to 552 sib-ships, recruited in Northern, Central and Southern Italy within the EU-funded project GEHA, followed for a six-year-survival. Main findings were: (i) "healthy" subjects varied within a large range, i.e. 5.2% (Gondo), 8.7% (Evert), 17.7% (Franceschi), and 28.5% (Andersen-Ranberg); (ii) Central Italy subjects showed better health than those from Northern and Southern Italy; (iii) mortality risk was correlated with health status independently of geographical areas; and (iv) 90+ males, although fewer in number, were healthier than females, but with no survival advantage. In conclusion, we identified a modified version of Andersen-Ranberg criteria, based on the concomitant assessment of two basic domains (cognitive, SMMSE; physical, ADL), called "Simple Model of Functional Status" (SMFS), as the most effective proxy to distinguish healthy from not-healthy subjects. This model showed that health status was correlated within sib-ships, suggesting a familial/genetic component.

OriginalsprogEngelsk
TidsskriftMechanisms of Ageing and Development
Vol/bind134
Nummer11-12
Sider (fra-til)560-9
Antal sider10
ISSN0047-6374
DOI
StatusUdgivet - 26 nov. 2013

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