Institut for Biomedicin

Lars Bolund

Array comparative genomic hybridization of keratoacanthomas and squamous cell carcinomas: different patterns of genetic aberrations suggest two distinct entities

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Jian Li
  • Kai Wang, Danmark
  • Fei Gao
  • ,
  • Thomas D Jensen, Danmark
  • Shengting T Li, Danmark
  • Paula M Deangelis
  • ,
  • Steen Kølvraa, Danmark
  • Charlotte Proby
  • ,
  • Ola Forslund
  • ,
  • Lars Bolund
  • Ole Petter F Clausen
Keratoacanthoma (KA) is a benign keratinocytic neoplasm that spontaneously regresses after 3-6 months and shares features with squamous cell carcinomas (SCCs). Furthermore, there are reports of KAs that have metastasized, invoking the question of whether KA is a variant of SCC (Hodak et al., 1993). To date, no reported criteria are sensitive enough to discriminate reliably between KA and SCC, and consequently there is a clinical need for discriminating markers. Our previous study analyzed 132 KAs and 29 SCCs and revealed significantly different regions of genomic aberrations using chromosomal comparative genomic hybridization (CGH). In the present study, we applied array CGH to investigate 98 KAs and 22 SCCs from the above samples. The result shows that all KAs and SCCs have some degree of genetic aberrations. The distribution of numbers of aberrant clones per sample differed significantly between KAs and SCCs (P
OriginalsprogEngelsk
TidsskriftJournal of Investigative Dermatology
Vol/bind132
Nummer8
Sider (fra-til)2060-6
Antal sider7
ISSN0022-202X
DOI
StatusUdgivet - 2012

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