Khalid Mahmood


Khalid Mahmood
Se relationer på Aarhus Universitet


I have multidisciplinary research background covering plant physiology, genomics and ecology. Currently, I am an Industerial Postdoc in the department of Agroecology, Aarhus University and Nordic Seed. My project entitled as "Genome wide association mapping, genomics prediction and transcriptomic to improve hybrid rye against fungal pathogens that cause Fusarium head blight and ergot in rye". In this project we are going to integrate and incorporate the phenotypic and genetic germplasm resources of resistance into elite rye lines of Nordic Seed A/S. We will use quantitative, computational genomic approaches to assist marker breeding selection of restant traits in Hybrid rye breeding. Previously at AU as Postdoc, I have been working on herbicide resistance  on project entitled "Deciphering microevolution of herbicide resistance using next generation sequencing technology". In this project we had applied RNAseq and various bioinformatic tools to identify and charactrize herbicide responsive genes, their differential expression in resistant individuals, allelic variation of resistant individuals and identify fintness cost associated to them. This project is part of the Evolution-Proof Pest Management (EvoPPM) project which involves studies on insecticide, fungicide, and herbicide resistance in agro-ecosystems. I did PhD at Copenhagen University. PhD thesis was “Genomic approaches towards identification of components involved in peptide based cell growth of Arabidopsis thaliana”. Research for this PhD thesis was aimed at understanding the molecular basis of the physiological responses triggered by the signaling peptide PSY1 based on a genome wide transcriptome analysis. This secreted peptide binds to a receptor kinase that phosphorylates the plasma membrane proton pump. It activation leads to cell apoplastic acidification resulting cell elongation.  My PhD project contributed to identification of other components in PSY1 peptide based cell elongation. During this work, I have gained extensive knowledge about use of genetic and bioinformatics tools to identify genes. Besides using various genomic approaches, I had also used other molecular and biochemical approaches for further characterization of identified genes. I did master in China. My thesis was "Induction of rice allelopathy through UV, defense signals and herbivores, and rice response to coumarin stress". Here I was investigated the induction and quantification of secondary metabolites (phenolics and terpenoids) through various stimulus.  I have screened rice genotypes based on phenotypic analysis to their tolerance, and provided insights about morphological, cytological and biochemical differences between resistant and susceptible genotypes. During this project, I gained experience in enzyme activity assay, metabolite profiling using metabolomics, gene expression analysis and phenotypic analysis. Overall being the "genome enabled field biologist" moivate me to understand how plants survive in nature and now with industerial experience learning how to apply those understanding on commercial scale. 

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