Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
Intramuscular temperature modulates glutamate-evoked masseter muscle pain intensity in humans. / Sato, Hitoshi; Castrillon, Eduardo E; Cairns, Brian E et al.
I: Journal of Oral & Facial Pain and Headache, Bind 29, Nr. 2, 2015, s. 158-67.Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Intramuscular temperature modulates glutamate-evoked masseter muscle pain intensity in humans
AU - Sato, Hitoshi
AU - Castrillon, Eduardo E
AU - Cairns, Brian E
AU - Bendixen, Karina H
AU - Wang, Kelun
AU - Nakagawa, Taneaki
AU - Wajima, Koichi
AU - Svensson, Peter
PY - 2015
Y1 - 2015
N2 - AIMS: To determine whether glutamate-evoked jaw muscle pain is altered by the temperature of the solution injected.METHODS: Sixteen healthy volunteers participated and received injections of hot (48°C), neutral (36°C), or cold (3°C) solutions (0.5 mL) of glutamate or isotonic saline into the masseter muscle. Pain intensity was assessed with an electronic visual analog scale (eVAS). Numeric rating scale (NRS) scores of unpleasantness and temperature perception, pain-drawing areas, and pressure pain thresholds (PPTs) were also measured. Participants filled out the McGill Pain Questionnaire (MPQ). Two-way or three-way repeated measures ANOVA were used for data analyses.RESULTS: Injection of hot glutamate and cold glutamate solutions significantly increased and decreased, respectively, the peak pain intensity compared with injection of neutral glutamate solution. The duration of glutamate-evoked pain was significantly longer when hot glutamate was injected than when cold glutamate was injected. No significant effect of temperature on pain intensity was observed when isotonic saline was injected. No effect of solution temperature was detected on unpleasantness, heat perception, cold perception, area of pain drawings, or PPTs. There was a significantly greater use of the "numb" term in the MPQ to describe the injection of cold solutions compared to the injection of both neutral and hot solutions.CONCLUSION: Glutamate-evoked jaw muscle pain was significantly altered by the temperature of the injection solution. Although temperature perception in the jaw muscle is poor, pain intensity is increased when the muscle tissue temperature is elevated.
AB - AIMS: To determine whether glutamate-evoked jaw muscle pain is altered by the temperature of the solution injected.METHODS: Sixteen healthy volunteers participated and received injections of hot (48°C), neutral (36°C), or cold (3°C) solutions (0.5 mL) of glutamate or isotonic saline into the masseter muscle. Pain intensity was assessed with an electronic visual analog scale (eVAS). Numeric rating scale (NRS) scores of unpleasantness and temperature perception, pain-drawing areas, and pressure pain thresholds (PPTs) were also measured. Participants filled out the McGill Pain Questionnaire (MPQ). Two-way or three-way repeated measures ANOVA were used for data analyses.RESULTS: Injection of hot glutamate and cold glutamate solutions significantly increased and decreased, respectively, the peak pain intensity compared with injection of neutral glutamate solution. The duration of glutamate-evoked pain was significantly longer when hot glutamate was injected than when cold glutamate was injected. No significant effect of temperature on pain intensity was observed when isotonic saline was injected. No effect of solution temperature was detected on unpleasantness, heat perception, cold perception, area of pain drawings, or PPTs. There was a significantly greater use of the "numb" term in the MPQ to describe the injection of cold solutions compared to the injection of both neutral and hot solutions.CONCLUSION: Glutamate-evoked jaw muscle pain was significantly altered by the temperature of the injection solution. Although temperature perception in the jaw muscle is poor, pain intensity is increased when the muscle tissue temperature is elevated.
KW - Adult
KW - Body Temperature
KW - Cold Temperature
KW - Female
KW - Glutamic Acid
KW - Hot Temperature
KW - Humans
KW - Hypesthesia
KW - Injections, Intramuscular
KW - Isotonic Solutions
KW - Male
KW - Masseter Muscle
KW - Myalgia
KW - Neurotransmitter Agents
KW - Pain Measurement
KW - Pain Threshold
KW - Pressure
KW - Sodium Chloride
KW - Thermosensing
KW - Young Adult
U2 - 10.11607/ofph.1332
DO - 10.11607/ofph.1332
M3 - Journal article
C2 - 25905534
VL - 29
SP - 158
EP - 167
JO - Journal of orofacial pain
JF - Journal of orofacial pain
SN - 1064-6655
IS - 2
ER -