Katrine J Emmertsen

Urinary dysfunction after colorectal cancer treatment and impact on quality of life- a national cross-sectional study in males

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AIM: Despite advances in treatment of colorectal cancer, post-operative urogenital dysfunction is still a problem though its exact extent remains unclear. The aim of this study was to identify the prevalence and patterns of urinary dysfunction in males following treatment for colorectal cancer and the impact of urinary dysfunction on quality of life.

METHOD: A retrospective national Danish cross-sectional study was performed in patients treated for colorectal cancer between 2001 and 2014. Patients answered questionnaires on urinary function and quality of life including the ICIQ-MLUTS measuring voiding and incontinence. Results were analysed based on data on demographics and treatment-related factors obtained from the Danish Colorectal Cancer Group (DCCG) database.

RESULTS: A total of 5,710 patients responded to the questionnaire (response rate 52.8%). In both crude analysis and after adjusting for patient-related factors (age, time since surgery and ASA score), both voiding (p<0.0001) and incontinence scores (p<0.0001) were significantly higher after rectal cancer than after colon cancer. In the rectal cancer group, abdominoperineal excision (APE) was found to be a significant risk factor for both voiding (p<0.0001) and incontinence (p=0.011), while radiotherapy only impaired continence (p=0.014). Significant correlations between high voiding and incontinence scores and impaired quality of life were found in both groups.

CONCLUSION: We found a high prevalence of urinary dysfunction following treatment for colorectal cancer, especially in the rectal cancer group. APE was the most significant risk factor for both voiding and incontinence. Urinary dysfunction significantly impairs patients' quality of life.

OriginalsprogEngelsk
TidsskriftColorectal Disease
Vol/bind23
Nummer2
ISSN1462-8910
DOI
StatusUdgivet - feb. 2021

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