Katrine J Emmertsen

Male erectile function after treatment for colorectal cancer: a population‐based cross‐sectional study

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AIM: To determine the knowledge gap in the field of erectile function (EF) after colorectal cancer surgery and investigate and compare the long-term male erectile function in colon and rectal cancer survivors in a National population.

METHOD: Danish male patients alive without evidence of recurrence treated for colon or rectal cancer between May 2001 and December 2014 were invited to participate. Using the International Index of Erectile Function (IIEF) score, and the derived dichotomized erectile dysfunction (ED) defined as moderate/severe or no/mild. Patients were grouped based on type of surgery (colon resection, rectal resection and local resection) and stratified for stoma, preoperative radiotherapy, age and ASA.

RESULTS: Of 10,037 eligible patients, 4.334 responded (43.18%). EF score was significantly lower for rectal resection (mean: 12.14) compared to both colon resection (mean: 15.82) and local resection (mean: 14.81) (p <0.0001). No significant difference between colon resections and local resection (p=0.29) was found. Both a stoma and use of radiotherapy were independent risk factors for ED. After excluding patients with stoma and radiotherapy and adjusting for age and ASA, rectal resection still had a higher risk of ED (OR: 1.42 CI: 1.20-1.67) compared to colon resection.

CONCLUSION: Rectal resection negatively affects EF. No difference between patients comparing colon resection and local resection was found. Radiotherapy and stoma were independent risk factors for ED.

STATEMENT: Treatment of colorectal cancer may impair erectile function. Here we present data from 4334 male cancer survivors. This is, to our knowledge, the largest cohort to date regarding erectile function among colorectal cancer survivors. This study found that Rectal resection, radiotherapy and stoma all negatively affect erectile function.

TidsskriftColorectal Disease
Sider (fra-til)367-375
Antal sider9
StatusUdgivet - feb. 2021

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