Katrine J Emmertsen

Low Anterior Resection Syndrome and Quality of Life After Sphincter-Sparing Rectal Cancer Surgery: A Long-term Longitudinal Follow-up

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Low Anterior Resection Syndrome and Quality of Life After Sphincter-Sparing Rectal Cancer Surgery : A Long-term Longitudinal Follow-up. / Pieniowski, Emil H A; Palmer, Gabriella J; Juul, Therese; Lagergren, Pernilla; Johar, Asif; Emmertsen, Katrine J; Nordenvall, Caroline; Abraham-Nordling, Mirna.

I: Diseases of the Colon and Rectum, Bind 62, Nr. 1, 01.2019, s. 14-20.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Pieniowski, Emil H A ; Palmer, Gabriella J ; Juul, Therese ; Lagergren, Pernilla ; Johar, Asif ; Emmertsen, Katrine J ; Nordenvall, Caroline ; Abraham-Nordling, Mirna. / Low Anterior Resection Syndrome and Quality of Life After Sphincter-Sparing Rectal Cancer Surgery : A Long-term Longitudinal Follow-up. I: Diseases of the Colon and Rectum. 2019 ; Bind 62, Nr. 1. s. 14-20.

Bibtex

@article{13d4e6f67ff04aaab0333d153098782e,
title = "Low Anterior Resection Syndrome and Quality of Life After Sphincter-Sparing Rectal Cancer Surgery: A Long-term Longitudinal Follow-up",
abstract = "BACKGROUND: Despite low anterior resection syndrome being a well-known consequence of sphincter-preserving rectal cancer surgery, the long-term effect on bowel function and quality of life is not fully understood.OBJECTIVE: This study aimed to elucidate whether symptoms of low anterior resection syndrome change over time and if the correlation to quality of life is equivalent when measured at 2 time points.DESIGN: This prospective cohort study included measurements at 2 time points (5 years between; range, 7.1-16.1 years from surgery to second follow-up).SETTINGS: This multicenter study included patients from Sweden and Denmark.PATIENTS: Patients were included if they were ≥18 years of age and underwent curative rectal cancer surgery with either total or partial mesorectal excision.MAIN OUTCOME MEASURES: Outcomes were measured with the low anterior resection syndrome questionnaire including a question assessing the impact of bowel function on quality of life and with the validated quality-of-life questionnaire EORTC QLQ-C30.RESULTS: In total, 282 patients were included and there were no statistically significant differences in the distribution among the 3 groups (no, minor, and major low anterior resection syndrome) when comparing time points follow-up 1 with follow-up 2 (p = 0.455). At follow-up 2, 138 patients (49%) still experienced major impairment. No both statistically and clinically significant differences were seen in the mean score of EORTC QLQ-C30 when comparing the same low anterior resection syndrome group at follow-up 1 and follow-up 2, and the impact on quality of life was comparable. Global health status/quality of life was impaired in the major low anterior resection syndrome group at both follow-up 1 (p < 0.001) and follow-up 2 (p < 0.001).LIMITATIONS: The study design prevents an evaluation of causality.CONCLUSIONS: Difficulties with low anterior resection syndrome and the impact on patients' quality of life persist over time. See Video Abstract at http://links.lww.com/DCR/A762.",
author = "Pieniowski, {Emil H A} and Palmer, {Gabriella J} and Therese Juul and Pernilla Lagergren and Asif Johar and Emmertsen, {Katrine J} and Caroline Nordenvall and Mirna Abraham-Nordling",
year = "2019",
month = jan,
doi = "10.1097/DCR.0000000000001228",
language = "English",
volume = "62",
pages = "14--20",
journal = "Diseases of the Colon and Rectum",
issn = "0012-3706",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "1",

}

RIS

TY - JOUR

T1 - Low Anterior Resection Syndrome and Quality of Life After Sphincter-Sparing Rectal Cancer Surgery

T2 - A Long-term Longitudinal Follow-up

AU - Pieniowski, Emil H A

AU - Palmer, Gabriella J

AU - Juul, Therese

AU - Lagergren, Pernilla

AU - Johar, Asif

AU - Emmertsen, Katrine J

AU - Nordenvall, Caroline

AU - Abraham-Nordling, Mirna

PY - 2019/1

Y1 - 2019/1

N2 - BACKGROUND: Despite low anterior resection syndrome being a well-known consequence of sphincter-preserving rectal cancer surgery, the long-term effect on bowel function and quality of life is not fully understood.OBJECTIVE: This study aimed to elucidate whether symptoms of low anterior resection syndrome change over time and if the correlation to quality of life is equivalent when measured at 2 time points.DESIGN: This prospective cohort study included measurements at 2 time points (5 years between; range, 7.1-16.1 years from surgery to second follow-up).SETTINGS: This multicenter study included patients from Sweden and Denmark.PATIENTS: Patients were included if they were ≥18 years of age and underwent curative rectal cancer surgery with either total or partial mesorectal excision.MAIN OUTCOME MEASURES: Outcomes were measured with the low anterior resection syndrome questionnaire including a question assessing the impact of bowel function on quality of life and with the validated quality-of-life questionnaire EORTC QLQ-C30.RESULTS: In total, 282 patients were included and there were no statistically significant differences in the distribution among the 3 groups (no, minor, and major low anterior resection syndrome) when comparing time points follow-up 1 with follow-up 2 (p = 0.455). At follow-up 2, 138 patients (49%) still experienced major impairment. No both statistically and clinically significant differences were seen in the mean score of EORTC QLQ-C30 when comparing the same low anterior resection syndrome group at follow-up 1 and follow-up 2, and the impact on quality of life was comparable. Global health status/quality of life was impaired in the major low anterior resection syndrome group at both follow-up 1 (p < 0.001) and follow-up 2 (p < 0.001).LIMITATIONS: The study design prevents an evaluation of causality.CONCLUSIONS: Difficulties with low anterior resection syndrome and the impact on patients' quality of life persist over time. See Video Abstract at http://links.lww.com/DCR/A762.

AB - BACKGROUND: Despite low anterior resection syndrome being a well-known consequence of sphincter-preserving rectal cancer surgery, the long-term effect on bowel function and quality of life is not fully understood.OBJECTIVE: This study aimed to elucidate whether symptoms of low anterior resection syndrome change over time and if the correlation to quality of life is equivalent when measured at 2 time points.DESIGN: This prospective cohort study included measurements at 2 time points (5 years between; range, 7.1-16.1 years from surgery to second follow-up).SETTINGS: This multicenter study included patients from Sweden and Denmark.PATIENTS: Patients were included if they were ≥18 years of age and underwent curative rectal cancer surgery with either total or partial mesorectal excision.MAIN OUTCOME MEASURES: Outcomes were measured with the low anterior resection syndrome questionnaire including a question assessing the impact of bowel function on quality of life and with the validated quality-of-life questionnaire EORTC QLQ-C30.RESULTS: In total, 282 patients were included and there were no statistically significant differences in the distribution among the 3 groups (no, minor, and major low anterior resection syndrome) when comparing time points follow-up 1 with follow-up 2 (p = 0.455). At follow-up 2, 138 patients (49%) still experienced major impairment. No both statistically and clinically significant differences were seen in the mean score of EORTC QLQ-C30 when comparing the same low anterior resection syndrome group at follow-up 1 and follow-up 2, and the impact on quality of life was comparable. Global health status/quality of life was impaired in the major low anterior resection syndrome group at both follow-up 1 (p < 0.001) and follow-up 2 (p < 0.001).LIMITATIONS: The study design prevents an evaluation of causality.CONCLUSIONS: Difficulties with low anterior resection syndrome and the impact on patients' quality of life persist over time. See Video Abstract at http://links.lww.com/DCR/A762.

U2 - 10.1097/DCR.0000000000001228

DO - 10.1097/DCR.0000000000001228

M3 - Journal article

C2 - 30394987

VL - 62

SP - 14

EP - 20

JO - Diseases of the Colon and Rectum

JF - Diseases of the Colon and Rectum

SN - 0012-3706

IS - 1

ER -