Katrine J Emmertsen

Bowel dysfunction after low anterior resection with and without neoadjuvant therapy for rectal cancer: a population-based cross-sectional study

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Bowel dysfunction after low anterior resection with and without neoadjuvant therapy for rectal cancer : a population-based cross-sectional study. / Bregendahl, Sidse; Emmertsen, Katrine Jøssing; Lous, Jørgen; Laurberg, Søren.

I: Colorectal Disease, 05.2013, s. 714-718.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{b3ff75c123b147a4a0b4267fd0fb0314,
title = "Bowel dysfunction after low anterior resection with and without neoadjuvant therapy for rectal cancer: a population-based cross-sectional study",
abstract = "AIM: Bowel dysfunction was assessed after low anterior resection with and without neoadjuvant therapy (NT) for rectal cancer using a novel symptom-based scoring system correlated with quality of life. METHOD: We identified all patients who underwent curative resection for rectal cancer in Denmark between 2001 and 2007. A questionnaire on bowel function and quality of life, including the recently validated 'Low Anterior Resection Syndrome Score' (LARS-score; range 0-42) was administered to recurrence-free patients in 2009. We used multivariate analysis to examine the association between major LARS (LARS-score≥30) and a number of patient and treatment-related factors. RESULTS: Of 1087 eligible patients, 980 agreed to participate, and a final 938 patients were included in the analysis. Major LARS was observed in 41%. The use of NT (OR=2.48; 95% CI 1.73-3.55), long course chemoradiotherapy vs short-course radiotherapy (OR=0.90; 95% CI 0.44-1.87), total mesorectal excision (TME) vs partial mesorectal excision (PME) (OR=2.31; 95% CI 1.69-3.16), anastomotic leakage (OR=2.06; 95% CI 0.93-4.55), age≤64 years at surgery (OR=1.90; 95% CI 1.43-2.51), and female gender (OR=1.35; 95% CI 1.02-1.79) were associated with major LARS. No association was found between major LARS and the interval since surgery (OR=0.78; 95% CI 0.59-1.04) or neorectal reconstruction (colonic pouch vs. straight colorectal or side-to-end anastomosis (OR=0.96; 95% CI 0.63-1.46). CONCLUSION: Severe bowel dysfunction is a frequent long-term outcome after resection for rectal cancer. Use of NT, regardless of a long or short course protocol, and TME (as opposed to PME) are strong independent risk factors for major LARS. This article is protected by copyright. All rights reserved.",
author = "Sidse Bregendahl and Emmertsen, {Katrine J{\o}ssing} and J{\o}rgen Lous and S{\o}ren Laurberg",
note = "This article is protected by copyright. All rights reserved.",
year = "2013",
month = may,
doi = "10.1111/codi.12244",
language = "English",
pages = "714--718",
journal = "Colorectal Disease",
issn = "1462-8910",
publisher = "Wiley-Blackwell Publishing Ltd.",

}

RIS

TY - JOUR

T1 - Bowel dysfunction after low anterior resection with and without neoadjuvant therapy for rectal cancer

T2 - a population-based cross-sectional study

AU - Bregendahl, Sidse

AU - Emmertsen, Katrine Jøssing

AU - Lous, Jørgen

AU - Laurberg, Søren

N1 - This article is protected by copyright. All rights reserved.

PY - 2013/5

Y1 - 2013/5

N2 - AIM: Bowel dysfunction was assessed after low anterior resection with and without neoadjuvant therapy (NT) for rectal cancer using a novel symptom-based scoring system correlated with quality of life. METHOD: We identified all patients who underwent curative resection for rectal cancer in Denmark between 2001 and 2007. A questionnaire on bowel function and quality of life, including the recently validated 'Low Anterior Resection Syndrome Score' (LARS-score; range 0-42) was administered to recurrence-free patients in 2009. We used multivariate analysis to examine the association between major LARS (LARS-score≥30) and a number of patient and treatment-related factors. RESULTS: Of 1087 eligible patients, 980 agreed to participate, and a final 938 patients were included in the analysis. Major LARS was observed in 41%. The use of NT (OR=2.48; 95% CI 1.73-3.55), long course chemoradiotherapy vs short-course radiotherapy (OR=0.90; 95% CI 0.44-1.87), total mesorectal excision (TME) vs partial mesorectal excision (PME) (OR=2.31; 95% CI 1.69-3.16), anastomotic leakage (OR=2.06; 95% CI 0.93-4.55), age≤64 years at surgery (OR=1.90; 95% CI 1.43-2.51), and female gender (OR=1.35; 95% CI 1.02-1.79) were associated with major LARS. No association was found between major LARS and the interval since surgery (OR=0.78; 95% CI 0.59-1.04) or neorectal reconstruction (colonic pouch vs. straight colorectal or side-to-end anastomosis (OR=0.96; 95% CI 0.63-1.46). CONCLUSION: Severe bowel dysfunction is a frequent long-term outcome after resection for rectal cancer. Use of NT, regardless of a long or short course protocol, and TME (as opposed to PME) are strong independent risk factors for major LARS. This article is protected by copyright. All rights reserved.

AB - AIM: Bowel dysfunction was assessed after low anterior resection with and without neoadjuvant therapy (NT) for rectal cancer using a novel symptom-based scoring system correlated with quality of life. METHOD: We identified all patients who underwent curative resection for rectal cancer in Denmark between 2001 and 2007. A questionnaire on bowel function and quality of life, including the recently validated 'Low Anterior Resection Syndrome Score' (LARS-score; range 0-42) was administered to recurrence-free patients in 2009. We used multivariate analysis to examine the association between major LARS (LARS-score≥30) and a number of patient and treatment-related factors. RESULTS: Of 1087 eligible patients, 980 agreed to participate, and a final 938 patients were included in the analysis. Major LARS was observed in 41%. The use of NT (OR=2.48; 95% CI 1.73-3.55), long course chemoradiotherapy vs short-course radiotherapy (OR=0.90; 95% CI 0.44-1.87), total mesorectal excision (TME) vs partial mesorectal excision (PME) (OR=2.31; 95% CI 1.69-3.16), anastomotic leakage (OR=2.06; 95% CI 0.93-4.55), age≤64 years at surgery (OR=1.90; 95% CI 1.43-2.51), and female gender (OR=1.35; 95% CI 1.02-1.79) were associated with major LARS. No association was found between major LARS and the interval since surgery (OR=0.78; 95% CI 0.59-1.04) or neorectal reconstruction (colonic pouch vs. straight colorectal or side-to-end anastomosis (OR=0.96; 95% CI 0.63-1.46). CONCLUSION: Severe bowel dysfunction is a frequent long-term outcome after resection for rectal cancer. Use of NT, regardless of a long or short course protocol, and TME (as opposed to PME) are strong independent risk factors for major LARS. This article is protected by copyright. All rights reserved.

U2 - 10.1111/codi.12244

DO - 10.1111/codi.12244

M3 - Journal article

C2 - 23581977

SP - 714

EP - 718

JO - Colorectal Disease

JF - Colorectal Disease

SN - 1462-8910

ER -