Kathrine Agergård Kaspersen

Symptoms reported by SARS-CoV-2 seropositive and seronegative healthcare and administrative employees in Denmark from May to August 2020

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

Background: The distribution and nature of symptoms among SARS-CoV-2 infected individuals need to be clarified. Methods: Between May and August 2020, 11 138 healthcare and administrative personnel from Central Denmark Region were tested for SARS-CoV-2 antibodies and subsequently completed a questionnaire. Symptom prevalence and overall duration for symptoms persisting for more than 30 days were calculated. Logistic regression models were used to estimate adjusted odds ratios (ORs) with 95% CIs. Results: In total, 447 (4%) of the participants were SARS-CoV-2-seropositive. Loss of sense of smell and taste was reported by 50% of seropositives compared with 3% of seronegatives. Additionally, seropositives more frequently reported fever, dyspnoea, muscle or joint ache, fatigue, cough, headache and sore throat, and they were more likely to report symptoms persisting for more than 30 days. In adjusted models, they had a higher risk of reporting symptoms, with the strongest association observed for loss of sense of taste and smell (OR = 35.6; 95% CI: 28.6–44.3). Conclusion: In this large study, SARS-CoV-2-seropositive participants reported COVID-19-associated symptoms more frequently than those who were seronegative, especially loss of sense of taste and smell. Overall, their symptoms were also more likely to persist for more than 30 days.

OriginalsprogEngelsk
TidsskriftInternational Journal of Infectious Diseases
Vol/bind109
Sider (fra-til)17-23
Antal sider7
ISSN1201-9712
DOI
StatusUdgivet - aug. 2021

Bibliografisk note

Funding Information:
The authors thank all staff involved in performing this study. Furthermore, the authors thank all healthcare and administrative personnel at hospitals, prehospital services and specialist practitioners in the Central Denmark Region participating in this study. This work was supported by The Central Denmark Region. The Wantai tests were donated by The Danish Health Authority requisitioned through Statens Serum Institut. KAK was supported by BERTHA ? the Danish Big Data Centre for Environment and Health funded by the Novo Nordisk Foundation Challenge Programme [grant number NNF17OC0027864]. The funders had no role in performing this study.

Funding Information:
This work was supported by The Central Denmark Region. The Wantai tests were donated by The Danish Health Authority requisitioned through Statens Serum Institut.

Funding Information:
KAK was supported by BERTHA – the Danish Big Data Centre for Environment and Health funded by the Novo Nordisk Foundation Challenge Programme [grant number NNF17OC0027864 ].

Publisher Copyright:
© 2021 The Authors

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