Kathrine Agergård Kaspersen

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Fatality Rate Among Elderly Danes: A Cross-sectional Study on Retired Blood Donors

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DOI

  • Ole Birger Pedersen, Københavns Universitet
  • ,
  • Janna Nissen, Københavns Universitet
  • ,
  • Khoa Manh Dinh
  • ,
  • Michael Schwinn, Københavns Universitet
  • ,
  • Kathrine Agergård Kaspersen
  • Jens Kjærgaard Boldsen
  • Maria Didriksen, Københavns Universitet
  • ,
  • Joseph Dowsett, Københavns Universitet
  • ,
  • Erik Sørensen, Københavns Universitet
  • ,
  • Lise Wegner Thørner, Københavns Universitet
  • ,
  • Margit Anita Hørup Larsen, Københavns Universitet
  • ,
  • Birgitte Grum-Schwensen, Innovational Counsil, Zealand University Hospital, Region Zealand
  • ,
  • Susanne Sækmose, Innovational Counsil, Zealand University Hospital, Region Zealand
  • ,
  • Isabella Worlewenut Paulsen, Innovational Counsil, Zealand University Hospital, Region Zealand
  • ,
  • Nanna Lond Skov Frisk, Innovational Counsil, Zealand University Hospital, Region Zealand
  • ,
  • Thorsten Brodersen, Innovational Counsil, Zealand University Hospital, Region Zealand
  • ,
  • Lasse Skafte Vestergaard, Statens Serum Inst, Statens Serum Institut, Dept Sexually Transmitted Dis
  • ,
  • Klaus Rostgaard, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
  • ,
  • Kåre Mølbak, Infection Disease Preparedness, Statens Serum Institut, Copenhagen, Denmark
  • ,
  • Robert Leo Skov, Infection Disease Preparedness, Statens Serum Institut, Copenhagen, Denmark
  • ,
  • Christian Erikstrup
  • Henrik Ullum, Department of Clinical Immunology, Copenhagen University Hospital.
  • ,
  • Henrik Hjalgrim, The Danish Multiple Sclerosis Registry, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark/Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Background: Although the vast majority of individuals succumbing to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are elderly, infection fatality rate (IFR) estimates for the age group ≥70 years are still scarce. To this end, we assessed SARS-CoV-2 seroprevalence among retired blood donors and combined it with national coronavirus disease 2019 (COVID-19) survey data to provide reliable population-based IFR estimates for this age group. Methods: We identified 60â-926 retired blood donors aged ≥70 years in the rosters of 3 regionwide Danish blood banks and invited them to fill in a questionnaire on COVID-19-related symptoms and behaviors. Among 24â-861 (40.8%) responders, we invited a random sample of 3200 individuals for blood testing. Overall, 1201 (37.5%) individuals were tested for SARS-CoV-2 antibodies (Wantai) and compared with 1110 active blood donors aged 17-69 years. Seroprevalence 95% confidence intervals (CIs) were adjusted for assay sensitivity and specificity. Results: Among retired (aged ≥70 years) and active (aged 17-69 years) blood donors, adjusted seroprevalences were 1.4% (95% CI,. 3-2.5%) and 2.5% (95% CI, 1.3-3.8%), respectively. Using available population data on COVID-19-related fatalities, IFRs for patients aged ≥70 years and for 17-69 years were estimated at 5.4% (95% CI, 2.7-6.4%) and. 083% (95% CI,. 054-.18%), respectively. Only 52.4% of SARS-CoV-2-seropositive retired blood donors reported having been sick since the start of the pandemic. Conclusions: COVID-19 IFR in the age group >69 years is estimated to be 65 times the IFR for people aged 18-69 years.

OriginalsprogEngelsk
TidsskriftClinical Infectious Diseases
Vol/bind73
Nummer9
Sider (fra-til)e2962-e2969
Antal sider8
ISSN1058-4838
DOI
StatusUdgivet - nov. 2021

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© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.

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