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Julie Schmidt

Protein and amino acid intakes in relation to prostate cancer risk and mortality-A prospective study in the European Prospective Investigation into Cancer and Nutrition

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

DOI

  • Julie A Schmidt
  • Inge Huybrechts, International Agency for Research on Cancer, Frankrig
  • Kim Overvad
  • Anne Kirstine Eriksen, Kræftens Bekæmpelse, Danmark
  • Anne Tjønneland, Kræftens Bekæmpelse, Københavns Universitet, Danmark
  • Rudolf Kaaks, German Cancer Research Center, Tyskland
  • Verena Katzke, German Institute of Human Nutrition Potsdam-Rehbruecke, Tyskland
  • Matthias B Schulze, German Institute of Human Nutrition Potsdam-Rehbruecke, University of Potsdam, Tyskland
  • Valeria Pala, IRCCS Fondazione Istituto Nazionale per lo studio e la cura dei tumori - Milano, Italien
  • Carlotta Sacerdote, University of Turin, Italien
  • Rosario Tumino, Hyblean Association for Epidemiological Research (AIRE-ONLUS), Italien
  • Bas Bueno-de-Mesquita, National Institute for Public Health and the Environment (RIVM), Holland
  • Maria-Jose Sánchez, Escuela Andaluza de Salud Publica, University of Granada, CIBER - Center for Biomedical Research Network, Spanien
  • José M Huerta, CIBER - Center for Biomedical Research Network, Murcia Regional Health Council, Spanien
  • Aurelio Barricarte, Navarra Institute for Health Research (IdiSNA), Spanien
  • Pilar Amiano, CIBER - Center for Biomedical Research Network, Ministry of Health of the Basque Government, Instituto de Investigación Sanitaria Biodonostia, Spanien
  • Antonio Agudo, Catalan Institute of Oncology - ICO, Nutrition and Cancer Group; Epidemiology, Public Health, Cancer Prevention and Palliative Care Program; Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Spanien
  • Anders Bjartell, Lund University, Sverige
  • Tanja Stocks, Lund University, Sverige
  • Elin Thysell, Umeå University, Sverige
  • Maria Wennberg, Umeå University, Sverige
  • Elisabete Weiderpass, International Agency for Research on Cancer, Frankrig
  • Ruth C Travis, University of Oxford, Storbritannien
  • Timothy J Key, University of Oxford, Storbritannien
  • Aurora Perez-Cornago, University of Oxford, Storbritannien

BACKGROUND: The association between protein intake and prostate cancer risk remains unclear.

AIMS: To prospectively investigate the associations of dietary intakes of total protein, protein from different dietary sources, and amino acids with prostate cancer risk and mortality.

METHODS: In 131,425 men from the European Prospective Investigation into Cancer and Nutrition, protein and amino acid intakes were estimated using validated dietary questionnaires. Multivariable-adjusted Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

RESULTS: During a mean follow-up of 14.2 years, 6939 men were diagnosed with prostate cancer and 914 died of the disease. Dairy protein was positively associated with overall prostate cancer risk in the three highest fifths compared to the lowest (HR Q3 =1.14 (95% CI 1.05-1.23); HR Q 4=1.09 (1.01-1.18); HR Q5 =1.10 (1.02-1.19)); similar results were observed for yogurt protein (HR Q3 =1.14 (1.05-1.24); HR Q4 =1.09 (1.01-1.18); HR Q5 =1.12 (1.04-1.21)). For egg protein intake and prostate cancer mortality, no association was observed by fifths, but there was suggestive evidence of a positive association in the analysis per standard deviation increment. There was no strong evidence of associations with different tumour subtypes.

DISCUSSION: Considering the weak associations and many tests, the results must be interpreted with caution.

CONCLUSION: This study does not provide strong evidence for an association of intakes of total protein, protein from different dietary sources or amino acids with prostate cancer risk or mortality. However, our results may suggest some weak positive associations, which need to be confirmed in large-scale, pooled analyses of prospective data.

OriginalsprogEngelsk
TidsskriftCancer Medicine
Vol/bind12
Nummer4
Sider (fra-til)4725-4738
Antal sider14
ISSN2045-7634
DOI
StatusUdgivet - feb. 2023

Bibliografisk note

© 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

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