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Julie Schmidt

Diet and BMI Correlate with Metabolite Patterns Associated with Aggressive Prostate Cancer

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

DOI

  • Zoe S Grenville, University of Oxford, Storbritannien
  • Urwah Noor, University of Oxford, Storbritannien
  • Mathilde His, International Agency for Research on Cancer, Frankrig
  • Vivian Viallon, International Agency for Research on Cancer, Frankrig
  • Sabina Rinaldi, International Agency for Research on Cancer, Frankrig
  • Elom K Aglago, Imperial College London, Storbritannien
  • Pilar Amiano, Ministry of Health of the Basque Government, Instituto de Investigación Sanitaria Biodonostia, CIBER - Center for Biomedical Research Network, Spanien
  • Louise Brunkwall, Lund University, Sverige
  • María Dolores Chirlaque, CIBER - Center for Biomedical Research Network, University of Murcia, Spanien
  • Isabel Drake, Lund University, Sverige
  • Fabian Eichelmann, German Institute of Human Nutrition Potsdam-Rehbruecke, Tyskland
  • Heinz Freisling, International Agency for Research on Cancer, Frankrig
  • Sara Grioni, IRCCS Fondazione Istituto Nazionale per lo studio e la cura dei tumori - Milano, Italien
  • Alicia K Heath, Imperial College London, Storbritannien
  • Rudolf Kaaks, German Cancer Research Center, Tyskland
  • Verena Katzke, German Cancer Research Center, Tyskland
  • Ana-Lucia Mayén-Chacon, International Agency for Research on Cancer, Frankrig
  • Lorenzo Milani, University of Turin, Italien
  • Conchi Moreno-Iribas, CIBER - Center for Biomedical Research Network, Universidad Pública de Navarra, Navarra Institute for Health Research (IdiSNA), Spanien
  • Valeria Pala, IRCCS Fondazione Istituto Nazionale per lo studio e la cura dei tumori - Milano, Italien
  • Anja Olsen
  • Maria-Jose Sánchez, Escuela Andaluza de Salud Publica, Instituto de Investigación Biosanitaria de Granada, CIBER - Center for Biomedical Research Network, University of Granada, Spanien
  • Matthias B Schulze, German Institute of Human Nutrition Potsdam-Rehbruecke, Tyskland
  • Anne Tjønneland, Københavns Universitet, Kræftens Bekæmpelse, Danmark
  • Konstantinos K Tsilidis, Imperial College London, University of Ioannina, Storbritannien
  • Elisabete Weiderpass, World Health Organization, Frankrig
  • Anna Winkvist, Umeå University, University of Gothenburg, Sverige
  • Raul Zamora-Ros, Catalan Institute of Oncology - ICO, Spanien
  • Timothy J Key, University of Oxford, Storbritannien
  • Karl Smith-Byrne, University of Oxford, Storbritannien
  • Ruth C Travis, University of Oxford, Storbritannien
  • Julie A Schmidt

Three metabolite patterns have previously shown prospective inverse associations with the risk of aggressive prostate cancer within the European Prospective Investigation into Cancer and Nutrition (EPIC). Here, we investigated dietary and lifestyle correlates of these three prostate cancer-related metabolite patterns, which included: 64 phosphatidylcholines and three hydroxysphingomyelins (Pattern 1), acylcarnitines C18:1 and C18:2, glutamate, ornithine, and taurine (Pattern 2), and 8 lysophosphatidylcholines (Pattern 3). In a two-stage cross-sectional discovery (n = 2524) and validation (n = 518) design containing 3042 men free of cancer in EPIC, we estimated the associations of 24 dietary and lifestyle variables with each pattern and the contributing individual metabolites. Associations statistically significant after both correction for multiple testing (False Discovery Rate = 0.05) in the discovery set and at p < 0.05 in the validation set were considered robust. Intakes of alcohol, total fish products, and its subsets total fish and lean fish were positively associated with Pattern 1. Body mass index (BMI) was positively associated with Pattern 2, which appeared to be driven by a strong positive BMI-glutamate association. Finally, both BMI and fatty fish were inversely associated with Pattern 3. In conclusion, these results indicate associations of fish and its subtypes, alcohol, and BMI with metabolite patterns that are inversely associated with risk of aggressive prostate cancer.

OriginalsprogEngelsk
Artikelnummer3306
TidsskriftNutrients
Vol/bind14
Nummer16
Antal sider14
ISSN2072-6643
DOI
StatusUdgivet - aug. 2022

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