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Julie Schmidt

Circulating Metabolites Associated with Alcohol Intake in the European Prospective Investigation into Cancer and Nutrition Cohort

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

DOI

  • Eline H van Roekel, Maastricht University, Holland
  • Laura Trijsburg, International Agency for Research on Cancer, Holland
  • Nada Assi, International Agency for Research on Cancer, Frankrig
  • Marion Carayol, Laboratoire Epsylon, Paul Valery University of Montpellier, 34090 Montpellier, France. Marion.Carayol@icm.unicancer.fr., Frankrig
  • David Achaintre, International Agency for Research on Cancer, Frankrig
  • Neil Murphy, International Agency for Research on Cancer, Frankrig
  • Sabina Rinaldi, International Agency for Research on Cancer, Frankrig
  • Julie A Schmidt
  • Magdalena Stepien, International Agency for Research on Cancer, Frankrig
  • Rudolf Kaaks, German Cancer Research Center, Tyskland
  • Tilman Kühn, German Cancer Research Center, Tyskland
  • Heiner Boeing, German Institute of Human Nutrition Potsdam-Rehbruecke, Tyskland
  • Khalid Iqbal, German Institute of Human Nutrition Potsdam-Rehbruecke, Tyskland
  • Domenico Palli, Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, 50141 Florence, Italy. d.palli@ispo.toscana.it., Italien
  • Vittorio Krogh, Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy. Vittorio.Krogh@istitutotumori.mi.it., Italien
  • Rosario Tumino, Cancer Registry and Histopathology Department, Civic-M.P.Arezzo Hospital, ASP, 97100 Ragusa, Italy. rtumino@tin.it., Italien
  • Fulvio Ricceri, Unit of Epidemiology, Regional Health Service ASL TO3, 10095 Turin, Italy. fulvio.ricceri@unito.it., Italien
  • Salvatore Panico, University of Naples Federico II, Italien
  • Petra H Peeters, University Medical Centre Utrecht, Holland
  • Bas Bueno-de-Mesquita, University of Malaya, Malaysia
  • Eva Ardanaz, CIBER de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain. me.ardanaz.aicua@cfnavarra.es., Spanien
  • Leila Lujan-Barroso, Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, 08908 Barcelona, Spain. llujan@iconcologia.net., Spanien
  • J Ramón Quirós, Public Health Directorate, 33005 Oviedo, Spain. epic_asturias@asturias.org., Spanien
  • José M Huerta, Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, 30008 Murcia, Spain. jmhuerta.carm@gmail.com., Spanien
  • Elena Molina-Portillo, Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs, GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, 18010 Granada, Spain. elena.molina.easp@juntadeandalucia.es., Spanien
  • Miren Dorronsoro, Basque Regional Health Department, Public Health Direction and Biodonostia Research Institute CIBERESP, 20014 Donostia, Spain. m-dorronsoro@euskadi.eus., Spanien
  • Konstantinos K Tsilidis, University of Ioannina, Grækenland
  • Elio Riboli, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London SW7 2AZ, UK. e.riboli@imperial.ac.uk., Storbritannien
  • Agnetha Linn Rostgaard-Hansen, Kræftens Bekæmpelse, Danmark
  • Anne Tjønneland, Kræftens Bekæmpelse, Danmark
  • Kim Overvad
  • Elisabete Weiderpass, Genetic Epidemiology Group, Folkhälsan Research Center, 00290 Helsinki, Finland. Elisabete.Weiderpass.Vainio@ki.se., Finland
  • Marie-Christine Boutron-Ruault, Gustave Roussy, 94800 Villejuif, France. marie-christine.boutron@gustaveroussy.fr., Frankrig
  • Gianluca Severi, Cancer Epidemiology Centre, Cancer Council Victoria and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia. gianluca.severi@gustaveroussy.fr., Frankrig
  • Antonia Trichopoulou, WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, 157 72 Athens, Greece. atrichopoulou@hhf-greece.gr., Grækenland
  • Anna Karakatsani, University of Athens, Grækenland
  • Anastasia Kotanidou, 1st Department of Critical Care Medicine & Pulmonary Services, University of Athens Medical School, Evangelismos Hospital, 10675 Athens, Greece. akotanid@gmail.com., Grækenland
  • Anders Håkansson, Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Psychiatry, SE-221 00 Lund, Sweden. anders_c.hakansson@med.lu.se., Sverige
  • Johan Malm, Department of Translational Medicine, Clinical Chemistry, Lund University, Skåne University Hospital, 205 02 Malmö, Sweden. johan.malm@med.lu.se., Sverige
  • Matty P Weijenberg, Maastricht University, Holland
  • Marc J Gunter, International Agency for Research on Cancer, Frankrig
  • Mazda Jenab, International Agency for Research on Cancer, Frankrig
  • Mattias Johansson, Genetic Epidemiology Group, Section of Genetics, International Agency for Research on Cancer (IARC-WHO), 69372 Lyon, France. johanssonm@iarc.fr., Frankrig
  • Ruth C Travis, Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK. ruth.travis@ndph.ox.ac.uk., Storbritannien
  • Augustin Scalbert, International Agency for Research on Cancer, Frankrig
  • Pietro Ferrari, International Agency for Research on Cancer, Frankrig

Identifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at recruitment was self-reported through dietary questionnaires. Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQTM p180 kit). Data were randomly divided into discovery (2/3) and replication (1/3) sets. Multivariable linear regression models were used to evaluate confounder-adjusted associations of alcohol consumption with metabolite concentrations. Metabolites significantly related to alcohol intake in the discovery set (FDR q-value < 0.05) were further tested in the replication set (Bonferroni-corrected p-value < 0.05). Of the 72 metabolites significantly related to alcohol intake in the discovery set, 34 were also significant in the replication analysis, including three acylcarnitines, the amino acid citrulline, four lysophosphatidylcholines, 13 diacylphosphatidylcholines, seven acyl-alkylphosphatidylcholines, and six sphingomyelins. Our results confirmed earlier findings that alcohol consumption was associated with several lipid metabolites, and possibly also with specific acylcarnitines and amino acids. This provides further leads for future research studies aiming at elucidating the mechanisms underlying the effects of alcohol in relation to morbid conditions.

OriginalsprogEngelsk
Artikelnummer654
TidsskriftNutrients
Vol/bind10
Nummer5
Antal sider18
ISSN2072-6643
DOI
StatusUdgivet - 22 maj 2018

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