Aarhus Universitets segl

Julie Schmidt

Associations between food group intakes and circulating insulin-like growth factor-I in the UK Biobank: a cross-sectional analysis

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review


  • Cody Z Watling, University of Oxford, Storbritannien
  • Rebecca K Kelly, University of Oxford
  • ,
  • Tammy Y N Tong, University of Oxford
  • ,
  • Carmen Piernas, University of Oxford, University of Granada
  • ,
  • Eleanor L Watts, University of Oxford
  • ,
  • Sandar Tin Tin, University of Oxford
  • ,
  • Anika Knuppel, University College London
  • ,
  • Julie A Schmidt
  • Ruth C Travis, University of Oxford
  • ,
  • Timothy J Key, University of Oxford
  • ,
  • Aurora Perez-Cornago, University of Oxford

Purpose: Circulating insulin-like growth factor-I (IGF-I) concentrations have been positively associated with risk of several common cancers and inversely associated with risk of bone fractures. Intakes of some foods have been associated with increased circulating IGF-I concentrations; however, evidence remains inconclusive. Our aim was to assess cross-sectional associations of food group intakes with circulating IGF-I concentrations in the UK Biobank. Methods: At recruitment, the UK Biobank participants reported their intake of commonly consumed foods. From these questions, intakes of total vegetables, fresh fruit, red meat, processed meat, poultry, oily fish, non-oily fish, and cheese were estimated. Serum IGF-I concentrations were measured in blood samples collected at recruitment. After exclusions, a total of 438,453 participants were included in this study. Multivariable linear regression was used to assess the associations of food group intakes with circulating IGF-I concentrations. Results: Compared to never consumers, participants who reported consuming oily fish or non-oily fish ≥ 2 times/week had 1.25 nmol/L (95% confidence interval:1.19–1.31) and 1.16 nmol/L (1.08–1.24) higher IGF-I concentrations, respectively. Participants who reported consuming poultry ≥ 2 times/week had 0.87 nmol/L (0.80–0.94) higher IGF-I concentrations than those who reported never consuming poultry. There were no strong associations between other food groups and IGF-I concentrations. Conclusions: We found positive associations between oily and non-oily fish intake and circulating IGF-I concentrations. A weaker positive association of IGF-I with poultry intake was also observed. Further research is needed to understand the mechanisms which might explain these associations.

TidsskriftEuropean Journal of Nutrition
Sider (fra-til)115-124
Antal sider10
StatusUdgivet - feb. 2023

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