Aarhus Universitets segl

Julie Schmidt

Adherence to the Mediterranean diet and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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  • Marta Solans, Epidemiology Unit and Girona Cancer Registry, Catalan Institute of Oncology, Girona, Spain., Spanien
  • Yolanda Benavente, Unit of molecular and genetic epidemiology in infections and cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain., Spanien
  • Marc Saez, University of Girona, Spanien
  • Antonio Agudo, Catalan Institute of Oncology - ICO, Spanien
  • Sabine Naudin, International Agency for Research on Cancer, Frankrig
  • Fatemeh Saberi Hosnijeh, 1] Department of Pediatric Oncology/Hematology, Sophia Children's Hospital-Erasmus University Medical Center, Rotterdam, The Netherlands [2] Department of Immunology, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands., Holland
  • Hwayoung Noh, International Agency for Research on Cancer, Frankrig
  • Heinz Freisling, International Agency for Research on Cancer, Frankrig
  • Pietro Ferrari, International Agency for Research on Cancer, Frankrig
  • Caroline Besson, Universite Paris-Sud, Frankrig
  • Yahya Mahamat-Saleh, Universite Paris-Sud, Frankrig
  • Marie-Christine Boutron-Ruault, Universite Paris-Sud, Frankrig
  • Tilman Kühn, German Cancer Research Center, Tyskland
  • Rudolf Kaaks, German Cancer Research Center, Tyskland
  • Heiner Boeing, Department of Epidemiology, German Institute of Human Nutrition (DIfE) Postdam-Rehbrücke, Nuthetal, Germany., Tyskland
  • Cristina Lasheras, University of Oviedo, Spanien
  • Miguel Rodríguez-Barranco, Escuela Andaluza de Salud Publica, Spanien
  • Pilar Amiano, Public Health Division of Gipuzkoa, Regional Government of the Basque Country, Donostia, Spain., Spanien
  • Jose Maria Huerta, Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain., Spanien
  • Aurelio Barricarte, Navarra Institute for Health Research (IdiSNA), Spanien
  • Julie A Schmidt
  • Paolo Vineis, Department of Epidemiology and Biostatistics, MRC-HPA Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom., Storbritannien
  • Elio Riboli, Imperial College London, Storbritannien
  • Antonia Trichopoulou, WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Grækenland
  • Christina Bamia, WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Grækenland
  • Eleni Peppa, WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Grækenland
  • Giovanna Masala, Institute for the Study and Prevention of Cancer (ISPRO), Italien
  • Claudia Agnoli, Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian, Milano, Italy., Italien
  • Rosario Tumino, Civic-M.P. Arezzo Hospital, Italien
  • Carlotta Sacerdote, Azienda Ospedaliera - Universitaria Città della Salute e della Scienza di Torino, Italien
  • Salvatore Panico, University of Naples Federico II, Italien
  • Guri Skeie, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway., Norge
  • Elisabete Weiderpass, Genetic Epidemiology Group, Folkhälsan Research Center and Faculty of Medicine, University of Helsinki, 00014 Helsinkiv, Finland. Elisabete.Weiderpass@kreftregisteret.no., Finland
  • Mats Jerkeman, Lund University, Sverige
  • Ulrika Ericson, Lund University, Sverige
  • Florentin Späth, Umeå University, Sverige
  • Lena Maria Nilsson, Umeå University, Sverige
  • Christina C Dahm
  • Kim Overvad
  • Anne Katrine Bolvig, Kræftens Bekæmpelse
  • ,
  • Anne Tjønneland, Københavns Universitet, Danmark
  • Silvia de Sanjose, PATH, Reproductive Health, Seattle, United States., USA
  • Genevieve Buckland, NIHR Bristol Biomedical Research Centre Nutrition Theme, Bristol, United Kingdom., Storbritannien
  • Roel Vermeulen, Utrecht University, Holland
  • Alexandra Nieters, University of Freiburg, Tyskland
  • Delphine Casabonne, Unit of molecular and genetic epidemiology in infections and cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain., Spanien

There is growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, no prospective study has yet investigated its influence on lymphoma. We evaluated the association between adherence to the MD and risk of lymphoma and its subtypes in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The analysis included 476,160 participants, recruited from ten European countries between 1991 and 2001. Adherence to the MD was estimated through an adapted relative Mediterranean diet (arMED) score excluding alcohol. Cox proportional hazards regression models were used while adjusting for potential confounders. During an average follow-up of 13.9 years, 3,136 lymphomas (135 Hodgkin lymphoma (HL), 2,606 non-Hodgkin lymphoma and 395 lymphoma NOS) were identified. Overall, a 1-unit increase in the arMED score was associated with a 2% lower risk of lymphoma (95% CI: 0.97; 1.00, p-trend=0.03) while a statistically non-significant inverse association between a high versus low arMED score and risk of lymphoma was observed (HR: 0.91 (95% CI 0.80; 1.03), p-trend=0.12). Analyses by lymphoma subtype did not reveal any statistically significant associations. Albeit with small numbers of cases (N= 135), a suggestive inverse association was found for HL (HR 1-unit increase= 0.93 (95% CI: 0.86; 1.01), p-trend=0.07). However, the study may have lacked statistical power to detect small effect sizes for lymphoma subtype. Our findings suggest that an increasing arMED score was inversely related to the risk of overall lymphoma in EPIC, but not by subtypes. Further large prospective studies are warranted to confirm these findings. This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftInternational Journal of Cancer
Vol/bind145
Nummer1
Sider (fra-til)122-131
Antal sider11
ISSN0020-7136
DOI
StatusUdgivet - 1 jul. 2019

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This article is protected by copyright. All rights reserved.

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