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Jibran Khan

Long-term residential exposure to PM2.5 constituents and mortality in a Danish cohort

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Long-term residential exposure to PM2.5 constituents and mortality in a Danish cohort. / Hvidtfeldt, Ulla Arthur; Geels, Camilla; Sørensen, Mette; Ketzel, Matthias; Khan, Jibran; Tjønneland, Anne; Christensen, Jesper Heile; Brandt, Jørgen; Raaschou-Nielsen, Ole.

I: Environment International, Bind 133, Nr. Part B, 105268, 12.2019.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Hvidtfeldt UA, Geels C, Sørensen M, Ketzel M, Khan J, Tjønneland A o.a. Long-term residential exposure to PM2.5 constituents and mortality in a Danish cohort. Environment International. 2019 dec;133(Part B). 105268. https://doi.org/10.1016/j.envint.2019.105268

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Bibtex

@article{5d24bf7972a74558814e6c6b2cf6acb0,
title = "Long-term residential exposure to PM2.5 constituents and mortality in a Danish cohort",
abstract = "Studies on health effects of long-term exposure to specific PM2.5 constituents are few. Previous studies have reported an association between black carbon (BC) exposure and cardiovascular diseases (CVD) and a few studies have found an association between sulfate exposure and mortality. These studies, however, relied mainly on exposure data from centrally located air-monitoring stations, which is a crude approximation of personal exposure. We focused on specific chemical constituents of PM2.5, i.e. elemental and primary organic carbonaceous particles (BC/OC), sea salt, secondary inorganic aerosols (SIA, i.e. NO3 –, NH4 +, and SO4 2-), and secondary organic aerosols (SOA), in relation to all-cause, CVD and respiratory disease mortality. We followed a Danish cohort of 49,564 individuals from enrollment in 1993–1997 through 2015. We combined residential address history from 1979 onwards with mean annual air pollution concentrations obtained by the AirGIS air pollution modelling system, lifestyle information from baseline questionnaires and socio-demography obtained by register linkage. During 895,897 person-years of follow-up, 10,193 deaths from all causes occurred – of which 2319 were CVD-related and 870 were related to respiratory disease. The 15-year time-weighted average concentrations of PM2.5, BC/OC, sea salt, SIA and SOA were 13.8, 2.8, 3.4, 4.9, and 0.3 µg/m3, respectively. For all-cause mortality, a higher risk was observed with higher exposure to PM2.5, BC/OC and SOA with adjusted hazard ratios of 1.03 (95% confidence intervals: 1.01, 1.05), 1.06 (1.03, 1.09), and 1.08 (1.03, 1.13) per interquartile range, respectively. The associations for BC/OC and SOA remained after adjustment for PM2.5 in two-pollutant models. For CVD mortality, we observed elevated risks with higher exposure to PM2.5, BC/OC and SIA. The results showed no clear relationship between sea salt and mortality. In this study, we observed a relationship between long-term exposure to PM2.5, BC/OC, and SOA and all-cause mortality and between PM2.5, BC/OC, and SIA and CVD mortality.",
keywords = "Carbonaceous particles, Mortality, Particulate matter chemical constituents, Sea salt, Secondary inorganic aerosols, Secondary organic aerosols",
author = "Hvidtfeldt, {Ulla Arthur} and Camilla Geels and Mette S{\o}rensen and Matthias Ketzel and Jibran Khan and Anne Tj{\o}nneland and Christensen, {Jesper Heile} and J{\o}rgen Brandt and Ole Raaschou-Nielsen",
year = "2019",
month = dec,
doi = "10.1016/j.envint.2019.105268",
language = "English",
volume = "133",
journal = "Environment International",
issn = "0160-4120",
publisher = "Pergamon Press",
number = "Part B",

}

RIS

TY - JOUR

T1 - Long-term residential exposure to PM2.5 constituents and mortality in a Danish cohort

AU - Hvidtfeldt, Ulla Arthur

AU - Geels, Camilla

AU - Sørensen, Mette

AU - Ketzel, Matthias

AU - Khan, Jibran

AU - Tjønneland, Anne

AU - Christensen, Jesper Heile

AU - Brandt, Jørgen

AU - Raaschou-Nielsen, Ole

PY - 2019/12

Y1 - 2019/12

N2 - Studies on health effects of long-term exposure to specific PM2.5 constituents are few. Previous studies have reported an association between black carbon (BC) exposure and cardiovascular diseases (CVD) and a few studies have found an association between sulfate exposure and mortality. These studies, however, relied mainly on exposure data from centrally located air-monitoring stations, which is a crude approximation of personal exposure. We focused on specific chemical constituents of PM2.5, i.e. elemental and primary organic carbonaceous particles (BC/OC), sea salt, secondary inorganic aerosols (SIA, i.e. NO3 –, NH4 +, and SO4 2-), and secondary organic aerosols (SOA), in relation to all-cause, CVD and respiratory disease mortality. We followed a Danish cohort of 49,564 individuals from enrollment in 1993–1997 through 2015. We combined residential address history from 1979 onwards with mean annual air pollution concentrations obtained by the AirGIS air pollution modelling system, lifestyle information from baseline questionnaires and socio-demography obtained by register linkage. During 895,897 person-years of follow-up, 10,193 deaths from all causes occurred – of which 2319 were CVD-related and 870 were related to respiratory disease. The 15-year time-weighted average concentrations of PM2.5, BC/OC, sea salt, SIA and SOA were 13.8, 2.8, 3.4, 4.9, and 0.3 µg/m3, respectively. For all-cause mortality, a higher risk was observed with higher exposure to PM2.5, BC/OC and SOA with adjusted hazard ratios of 1.03 (95% confidence intervals: 1.01, 1.05), 1.06 (1.03, 1.09), and 1.08 (1.03, 1.13) per interquartile range, respectively. The associations for BC/OC and SOA remained after adjustment for PM2.5 in two-pollutant models. For CVD mortality, we observed elevated risks with higher exposure to PM2.5, BC/OC and SIA. The results showed no clear relationship between sea salt and mortality. In this study, we observed a relationship between long-term exposure to PM2.5, BC/OC, and SOA and all-cause mortality and between PM2.5, BC/OC, and SIA and CVD mortality.

AB - Studies on health effects of long-term exposure to specific PM2.5 constituents are few. Previous studies have reported an association between black carbon (BC) exposure and cardiovascular diseases (CVD) and a few studies have found an association between sulfate exposure and mortality. These studies, however, relied mainly on exposure data from centrally located air-monitoring stations, which is a crude approximation of personal exposure. We focused on specific chemical constituents of PM2.5, i.e. elemental and primary organic carbonaceous particles (BC/OC), sea salt, secondary inorganic aerosols (SIA, i.e. NO3 –, NH4 +, and SO4 2-), and secondary organic aerosols (SOA), in relation to all-cause, CVD and respiratory disease mortality. We followed a Danish cohort of 49,564 individuals from enrollment in 1993–1997 through 2015. We combined residential address history from 1979 onwards with mean annual air pollution concentrations obtained by the AirGIS air pollution modelling system, lifestyle information from baseline questionnaires and socio-demography obtained by register linkage. During 895,897 person-years of follow-up, 10,193 deaths from all causes occurred – of which 2319 were CVD-related and 870 were related to respiratory disease. The 15-year time-weighted average concentrations of PM2.5, BC/OC, sea salt, SIA and SOA were 13.8, 2.8, 3.4, 4.9, and 0.3 µg/m3, respectively. For all-cause mortality, a higher risk was observed with higher exposure to PM2.5, BC/OC and SOA with adjusted hazard ratios of 1.03 (95% confidence intervals: 1.01, 1.05), 1.06 (1.03, 1.09), and 1.08 (1.03, 1.13) per interquartile range, respectively. The associations for BC/OC and SOA remained after adjustment for PM2.5 in two-pollutant models. For CVD mortality, we observed elevated risks with higher exposure to PM2.5, BC/OC and SIA. The results showed no clear relationship between sea salt and mortality. In this study, we observed a relationship between long-term exposure to PM2.5, BC/OC, and SOA and all-cause mortality and between PM2.5, BC/OC, and SIA and CVD mortality.

KW - Carbonaceous particles

KW - Mortality

KW - Particulate matter chemical constituents

KW - Sea salt

KW - Secondary inorganic aerosols

KW - Secondary organic aerosols

UR - http://www.scopus.com/inward/record.url?scp=85074167265&partnerID=8YFLogxK

U2 - 10.1016/j.envint.2019.105268

DO - 10.1016/j.envint.2019.105268

M3 - Journal article

C2 - 31675564

AN - SCOPUS:85074167265

VL - 133

JO - Environment International

JF - Environment International

SN - 0160-4120

IS - Part B

M1 - 105268

ER -