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Jens Christian Jensenius

Susceptibility to Leprosy is Associated with M-ficolin Polymorphisms

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

DOI

  • Angelica B W Boldt
    • ,
  • Maria Iolanda N Sanchez
    • ,
  • Ewalda R S Stahlke
    • ,
  • Rudi Steffensen, Aalborg Universitet, Danmark
  • Steffen Thiel
  • Jens C Jensenius
  • Flávia Costa Prevedello
    • ,
  • Marcelo Távora Mira
    • ,
  • Jürgen F J Kun
    • ,
  • Iara J T Messias-Reason
Mycobacterium leprae exploits complement activation and opsonophagocytosis to infect phagocytes. M-ficolin is encoded by the FCN1 gene and initiates the lectin pathway on monocyte surfaces. We investigated FCN1 promoter polymorphisms that could be responsible for the high interindividual variability of M-ficolin levels and for modulating leprosy susceptibility.
OriginalsprogEngelsk
TidsskriftJournal of Clinical Immunology
Vol/bind33
Nummer1
Sider (fra-til)210-9
Antal sider10
ISSN0271-9142
DOI
StatusUdgivet - 2013

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