Aarhus Universitets segl

Jens Christian Jensenius

Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Alvaro Cervera
  • ,
  • Anna M Planas
  • ,
  • Carles Justicia
  • ,
  • Xabier Urra
  • ,
  • Jens Christian Jensenius
  • Ferran Torres
  • ,
  • Francisco Lozano
  • ,
  • Angel Chamorro
The complement system is a major effector of innate immunity that has been involved in stroke brain damage. Complement activation occurs through the classical, alternative and lectin pathways. The latter is initiated by mannose-binding lectin (MBL) and MBL-associated serine proteases (MASPs). Here we investigated whether the lectin pathway contributes to stroke outcome in mice and humans.
TidsskriftP L o S One
Sider (fra-til)e8433
StatusUdgivet - 2010

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