Jens Aage Kølsen Petersen

Forearm substrate exchange during hyperinsulinaemic hypoglycaemia in normal man

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  • N Abildgaard, *Division of Pediatric Hematology/Oncology, Faculty of Medicine, Atatürk University, Erzurum §Division of Pediatric Hematology/Oncology, Faculty of Medicine, Sakarya University, Sakarya, Turkey †Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark ‡Departments of Biochemistry and Pediatrics, Children's Health Research Institute, University of Western Ontario, London, ON, Canada.
  • ,
  • L Orskov
  • ,
  • J A Petersen
  • K G Alberti
  • ,
  • O Schmitz
  • N Møller

To assess muscle substrate exchange during hypoglycaemia, 8 healthy young male subjects were studied twice during 2 h of hyperinsulinaemic euglycaemia followed by 4 h of (1) hypoglycaemia (plasma glucose < 2.8 mmol l-1), and (2) euglycaemia. Insulin was infused at a rate of 1.5 mU kg-1 min-1 throughout. When compared to euglycaemia, hypoglycaemia was associated with: (1) increment in circulating glucagon (65 +/- 8 vs 23 +/- 4 ng l-1, p < 0.05), growth hormone (19.9 +/- 3.6 vs 2.6 +/- 1.3 micrograms l-1, p < 0.05), adrenaline (410 +/- 88 vs 126 +/- 32 ng l-1, p < 0.05) and increased suppression of C-peptide (0.5 +/- 0.1 vs 1.0 +/- 0.1 micrograms l-1, p < 0.05) along with a modest lowering of insulin (103 +/- 10 vs 130 +/- 13 mU l-1, p < 0.05); (b) decrease in plasma glucose level (3.0 +/- 0.07 vs 5.0 +/- 0.12 mmol l-1, p < 0.05), forearm glucose uptake (0.21 +/- 0.09 vs 1.21 +/- 0.21 mmol l-1, p < 0.05) and requirement for exogenous glucose (5.6 +/- 1.1 vs 13.2 +/- 0.9 mg kg-1 min-1 p < 0.005) together with an impaired suppression of isotopically determined endogenous glucose production (0.34 +/- 0.5 vs -2.3 +/- 0.3 mg kg-1 min-1, p < 0.05); (3) exaggerated increase in blood lactate (1680 +/- 171 vs 1315 +/- 108 mumol l-1, p < 0.05) and a decrease in alanine (215 +/- 18 vs 262 +/- 19 mumol l-1, p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

OriginalsprogEngelsk
TidsskriftDiabetic medicine : a journal of the British Diabetic Association
Vol/bind12
Nummer3
Sider (fra-til)218-23
Antal sider6
ISSN0742-3071
DOI
StatusUdgivet - mar. 1995

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