Jens Aage Kølsen Petersen

Endoscopic sclerotherapy in porcine esophagus changes luminal cross-sectional area and wall distensibility dose- and time-dependently

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Endoscopic sclerotherapy in porcine esophagus changes luminal cross-sectional area and wall distensibility dose- and time-dependently. / Petersen, J A; Djurhuus, C; Koff, J et al.

I: Digestive Diseases and Sciences, Bind 43, Nr. 3, 03.1998, s. 521-8.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Petersen, JA, Djurhuus, C, Koff, J, Vinter-Jensen, L & Gregersen, H 1998, 'Endoscopic sclerotherapy in porcine esophagus changes luminal cross-sectional area and wall distensibility dose- and time-dependently', Digestive Diseases and Sciences, bind 43, nr. 3, s. 521-8. https://doi.org/10.1023/a:1018802922374

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CBE

MLA

Vancouver

Petersen JA, Djurhuus C, Koff J, Vinter-Jensen L, Gregersen H. Endoscopic sclerotherapy in porcine esophagus changes luminal cross-sectional area and wall distensibility dose- and time-dependently. Digestive Diseases and Sciences. 1998 mar.;43(3):521-8. doi: 10.1023/a:1018802922374

Author

Petersen, J A ; Djurhuus, C ; Koff, J et al. / Endoscopic sclerotherapy in porcine esophagus changes luminal cross-sectional area and wall distensibility dose- and time-dependently. I: Digestive Diseases and Sciences. 1998 ; Bind 43, Nr. 3. s. 521-8.

Bibtex

@article{fbc2d3adc16846c4844ffb637c8e5233,
title = "Endoscopic sclerotherapy in porcine esophagus changes luminal cross-sectional area and wall distensibility dose- and time-dependently",
abstract = "The dose- and time-dependent effects of endoscopic sclerotherapy on luminal cross-sectional area and wall distensibility were studied in pigs at 5 and 12 cm proximal to the gastroesophageal junction by means of impedance planimetry. Sixteen healthy animals underwent two sessions of endoscopic sclerotherapy two weeks apart with injections of either 5 or 10 ml of 1% Polidocanol in the distal 7 cm of the esophagus each time. The animals were investigated before sclerotherapy, two weeks after each session, and finally six weeks after the last session. Six healthy animals were studied as controls. Endoscopic sclerotherapy caused luminal narrowing in the sclerosed zone followed by normalization six weeks after the last treatment (P < 0.05 in both groups). Wall distensibility decreased in the sclerosed zone after treatment with 10 ml sclerosant (P < 0.05) followed by partial normalization, while no effect was found after 5 ml sclerosant (P > 0.2). Progressive dilations were observed in the proximal esophagus in both groups and were most pronounced in the 10 ml group (P < 0.05). Wall distensibility did not change proximal to the site of sclerotherapy in either group (P > 0.1).",
keywords = "Animals, Esophageal and Gastric Varices/therapy, Esophagus/drug effects, Female, Hemostasis, Endoscopic, Polidocanol, Polyethylene Glycols/therapeutic use, Pressure, Sclerosing Solutions/therapeutic use, Sclerotherapy/methods, Swine, Time Factors",
author = "Petersen, {J A} and C Djurhuus and J Koff and L Vinter-Jensen and H Gregersen",
year = "1998",
month = mar,
doi = "10.1023/a:1018802922374",
language = "English",
volume = "43",
pages = "521--8",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Endoscopic sclerotherapy in porcine esophagus changes luminal cross-sectional area and wall distensibility dose- and time-dependently

AU - Petersen, J A

AU - Djurhuus, C

AU - Koff, J

AU - Vinter-Jensen, L

AU - Gregersen, H

PY - 1998/3

Y1 - 1998/3

N2 - The dose- and time-dependent effects of endoscopic sclerotherapy on luminal cross-sectional area and wall distensibility were studied in pigs at 5 and 12 cm proximal to the gastroesophageal junction by means of impedance planimetry. Sixteen healthy animals underwent two sessions of endoscopic sclerotherapy two weeks apart with injections of either 5 or 10 ml of 1% Polidocanol in the distal 7 cm of the esophagus each time. The animals were investigated before sclerotherapy, two weeks after each session, and finally six weeks after the last session. Six healthy animals were studied as controls. Endoscopic sclerotherapy caused luminal narrowing in the sclerosed zone followed by normalization six weeks after the last treatment (P < 0.05 in both groups). Wall distensibility decreased in the sclerosed zone after treatment with 10 ml sclerosant (P < 0.05) followed by partial normalization, while no effect was found after 5 ml sclerosant (P > 0.2). Progressive dilations were observed in the proximal esophagus in both groups and were most pronounced in the 10 ml group (P < 0.05). Wall distensibility did not change proximal to the site of sclerotherapy in either group (P > 0.1).

AB - The dose- and time-dependent effects of endoscopic sclerotherapy on luminal cross-sectional area and wall distensibility were studied in pigs at 5 and 12 cm proximal to the gastroesophageal junction by means of impedance planimetry. Sixteen healthy animals underwent two sessions of endoscopic sclerotherapy two weeks apart with injections of either 5 or 10 ml of 1% Polidocanol in the distal 7 cm of the esophagus each time. The animals were investigated before sclerotherapy, two weeks after each session, and finally six weeks after the last session. Six healthy animals were studied as controls. Endoscopic sclerotherapy caused luminal narrowing in the sclerosed zone followed by normalization six weeks after the last treatment (P < 0.05 in both groups). Wall distensibility decreased in the sclerosed zone after treatment with 10 ml sclerosant (P < 0.05) followed by partial normalization, while no effect was found after 5 ml sclerosant (P > 0.2). Progressive dilations were observed in the proximal esophagus in both groups and were most pronounced in the 10 ml group (P < 0.05). Wall distensibility did not change proximal to the site of sclerotherapy in either group (P > 0.1).

KW - Animals

KW - Esophageal and Gastric Varices/therapy

KW - Esophagus/drug effects

KW - Female

KW - Hemostasis, Endoscopic

KW - Polidocanol

KW - Polyethylene Glycols/therapeutic use

KW - Pressure

KW - Sclerosing Solutions/therapeutic use

KW - Sclerotherapy/methods

KW - Swine

KW - Time Factors

U2 - 10.1023/a:1018802922374

DO - 10.1023/a:1018802922374

M3 - Journal article

C2 - 9539646

VL - 43

SP - 521

EP - 528

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 3

ER -