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Institut for Klinisk Medicin

Jan Frystyk

Jan Frystyk
Professor, dr. med.
Institut for Klinisk Medicin - Medicinsk Endokrinologisk afdeling MEA, NBG
Institut for Klinisk Medicin - Medicinsk Forskningslaboratorium, NBG

Nørrebrogade 44, 3, kld., 29
8000 Aarhus C
Danmark
E-mail: frystyk@clin.au.dk
Direkte telefon: 7846 2166
Mobiltelefon: 2330 0330

Degrees and current position

2011	Professor at Dept. of Clinical Medicine, Aarhus University and chief physician at Dept. of Endocrinology and Internal Medicine, Aarhus University Hospital, DK
2009	Qualified as professor in Experimental Medical Research
2007	Associate professor at Dept. of Clinical Medicine, Aarhus University and chief physician at Dept. of Endocrinology and Internal Medicine, Aarhus University Hospital
2006	Qualification as endocrinologist
2004	Graduation as Doctor of Medical Science (DMSc) from University of Aarhus
1996	Graduation as PhD from University of Aarhus, Denmark
1992	Graduation from Medical School, University of Aarhus, Denmark

Teaching

Organizer of pre-graduate courses in medical research at Aarhus University
Organizer of post-graduate courses in laboratory techniques and endocrinology at Aarhus University and at Aarhus University Hospital
Speaker at national and international conferences (selected and invited presentations)
Speaker at courses in growth hormone, insulin-like growth factors and assay methodologies / clinical use

Supervisor

Altogether 15 medical students / MDs / PhDs during the last 10 years.
Currently supervision of 1 assoc. professor, 1 post doc, 3 PhD students and 2 pre-graduate students

Supervisor function at Medical Research Laboratory, Department of Clinical Research, Aarhus University, Denmark

2014	Medical Student Jonas Agerholm (primary supervisor)
2014	Molecular biology student Maiken Aagaard (primary supervisor)
2013	Medical Student Wajd Hassan (primary supervisor)
2013	Medical student Mia-Majken Kallestrup Jørgensen (supervisor)
2011	MD, PhD student Mark Reinhard (supervisor)
2011	Medical student Jacob Thomsen (primary supervisor)
2011	Molecular Medicine student Rikke Hjortebjerg (primary supervisor)
2011	MD, PhD student Morten Bramsen (supervisor)
2011	MD, PhD student Jesper Sand Sørensen (supervisor)
2010	Medical student Mette Faurholdt Rasmussen (primary supervisor)
2009-2013	PhD student Zhulin Ma (primary supervisor)
2009-2013	MD, PhD student Ulrick Espelund (primary supervisor)
2009-2011	MD Trine Christensen (primary supervisor)
2008-2009	MD Ulrick Espelund (primary supervisor)
2007-2010	MD, PhD student Grazina Urbonaviciene (supervisor)
2007-2009	Medical student Nilani Jeyaratnaganthan (primary supervisor)
2007-2008	Medical student Henrik Rindsig Leth (primary supervisor)
2006	MD Caroline Marie Andreasen (primary supervisor)
2005	Medical students Nanna Houe, Louise Ryder, Kristina Öbrink (supervisor)
2005-2006	Medical student Gowsini Joseph Alfred (primary supervisor)
2004-2009	MD, PhD student Trine Bay Laursen (supervisor)
2003-2005	Medical student Anne Vestergaard Møller (primary supervisor)
2003-2004	Medical student Andreas Rudkøbing (supervisor)
2002-2008	Medical student Ulrick Espelund (primary supervisor)
2001-2006	MD, PhD student Jian-Wen Chen (supervisor)
2000-2002	Medical student Søren Peter Jørgensen (primary supervisor)
1995-1998	MD, PhD student Christian Skjærbæk (supervisor)
1992-1994	1992-94 Medical student Christian Skjærbæk (supervisor)

Chairs at international scientific meetings

2012	7th International Growth Hormone – IGF meeting, Munich, Germany (program organizing committee)
2010	6th International Growth Hormone – IGF meeting, New York, USA
2007	5th International Growth Hormone – IGF meeting, Genoa, Italy
2002	37th Scandinavian Society for the Study of Diabetes, Aarhus, Denmark
1999	5th International Meeting on Insulin-like Growth Factors, Brighton, UK

Scientific boards, editorial appointments etc.

2013-	Editor in Chief of Growth Hormone and IGF Research; impact +2
2010-2013	Editorial Board Member at Journal of Clinical Endocrinology and Metabolism; impact factor ~6
2009-2010	Senior Editor Journal of Molecular Endocrinology; impact factor ~3
2008-2009	Assistant Editor Journal of Molecular Endocrinology; impact factor ~3
2006	Scientific advisory committee Hoffmann-La Roche
2006-2012	Assistant Editor of Growth Hormone and IGF Research; impact factor +2 (handled more than 140 papers)
2005-2006	Editor International Growth Monitor

University positions

2012-	Member of the Education Committee of the Danish Diabetes Academy
2012-2013	Member of a working group describing the scientific code of conduct at Faculty of Health, Aarhus University
2012-	Member of the Scientific Data Security Group at Aarhus University
2011	Leader of PhD courses in Molecular Medicine and Endocrinology at Faculty of Health, Aarhus University
2011-2012	Board member of The Molecular Medicine and Endocrinology Research Network between Southern Danish Univ., Copenhagen Univ. and Aarhus Univ.
2010-2011	Member of the study board at Molecular Medicine, Faculty of Health, Aarhus University

Appointment as examiner / opponent / member of assessment committees

2013	Head of doctoral thesis (DMSc) evaluation committee at Aarhus University. Title: "Soluble CD163"
2012	DMSc opponent at Karolinska Institute, Stockholm. Title: "Proteolysis of insulin-like growth factor binding protein -1, -2 and -4: function of fragments"
2012	Head of professor assessment committee (professor in cardiovascular endocrinology)
2012	Head of PhD evaluation committee at Aarhus University. Title: "Quantitative measurements of trefoil factor family peptides: possibilities and pitfalls"
2011	Head of PhD evaluation committee, Health, Aarhus University. Title: "Risk prediction and prognosis following cardiac surgery: the EuroSCORE and new potential prognostic factors"
2011	Member of the scientific evaluation committee for the promotion of assistant professor Kevin Yuen, Oregon Health and Science University, USA
2009	PhD opponent at Copenhagen University. Title: "Structure function and evolution of the ligands and receptors of the insulin peptide family"
2009	PhD opponent at Aarhus University. Title: "Zebra-fish PAPP-A in vitro and in vivo"
2007	Head of PhD evaluation committee, Health, Aarhus University. Title: "Recovery and serotonergic neurotransmission in the wake of stroke and aging"
2007	PhD opponent at Copenhagen University. Title: "The molecular basis of the signaling specificity of insulin, IGF-I and IGF-II"
2007	DMSc opponent at Karolinska Institute, Stockholm. Title: "The GH /IGF system during surgery and catabolism – focus on metabolism and heart function"
2002	PhD opponent at Copenhagen University. Title: "Receptor binding mechanism of insulin and IGF-I"

Referee

Regular reviewer for well-esteemed journals (> 130 papers).

Among others: European Journal of Endocrinology, Diabetes Care, Journal of Clinical Endocrinology and Metabolism, American Journal of Physiology, Endocrinology and Metabolism.

Personal awards

2013	Frøknerne Anna og Dagny Hjerrilds Fond til anskaffelse af dyreforsøg i den videnskabelige forskning (DKK 200,000)
2009	Professor Schwartz-Sørensen Research award (DKK 25,000)
2006	Bookkeeper Søren Karl Thomsen and wife Margrethe Nielsine Thomsen’s grant (DKK 12,000)
2004	The Odd Fellow Foundation in Odder (Svend Fælding), Denmark (DKK 20,000)
2002	Family Hede-Nielsen Foundation scientific award (DKK 200,000)
1992	Ingeborg Maibølls Foundation (DKK 17,000)

Grants (total amount ~ 13 million DKK ~ 1,700,000 Euro)

2013	The A.P. Møller Foundation for the Advancement of Medical Science (DKK 50,000)
2013	Karen Elise Jensen's Foundation (DKK 766,000)
2013	Institute of Clinical Medicine, Faculty of Health Sciences, Aarhus University (DKK 150,000)
2012	The Riisfort-Foundation (DKK 353,000)
2012	The Beckett-Foundation (DKK 75,000)
2012	Institute of Clinical Medicine, Faculty of Health Sciences, Aarhus University (DKK 100,000)
2011	Clinical Institute, Faculty of Health Sciences, Aarhus University (DKK 40,000)
2011	Arvid Nilssons Fond (DKK 300,000)
2011	The Danish Medical Research Council (DKK 216,000)
2011	Seed money from Faculty of Health Sciences, Aarhus University (DKK 1,965,000)
2011	The Danish Medical Research Council (DKK 1,290,241)
2011	The A.P. Møller Foundation for the Advancement of Medical Science (DKK 35,000)
2011	The Harboe Foundation (DKK 15,000)
2010	Clinical Institute, Aarhus University (DKK 40,000)
2010	The Beckett-Foundation (DKK 100,000)
2010	Augustinus Foundation (DKK 100,000)
2010	The A.P. Møller Foundation for the Advancement of Medical Science (DKK 50,000)
2009	Clinical Institute, Aarhus University (DKK 40,000)
2009	The Novo Nordisk Foundation (DKK 300,000)
2009	The Danish Medical Research Council (DKK 1,073,000)
2009	The Danish Medical Research Council (DKK 194,000)
2008	The Danish Cancer Society (DKK 625,000)
2008	Danish Lung Association (DKK 90,500)
2008	The Research Fund of Central Denmark Region (DKK 80,000)
2007	The Danish Medical Research Council (DKK 162,000) (scholarship to medical student)
2007	Kathrine and Vigo Skovgaard Foundation (DKK 75,000)
2007	Aarhus University Research Foundation (DKK 25,000)
2007	The Family Hede-Nielsens Foundation (DKK 25,000)
2007	Vera and Flemming Westerbergs Foundation (DKK 50,000)
2006	The Helga and Peter Kornings Foundation (DKK 35,000)
2005	The Danish Medical Research Council (DKK 162,000) (scholarship to medical student)
2005	The Danish Medical Research Council (DKK 1,082,550)
2005	The Danish Diabetes Association (DKK 70,000)
2004	The Danish Medical Research Council (DKK 162,000) (scholarship to medical student)
2003	Bernhard and Marie Kleins Grant for Diabetes Research (DKK. 15,000)
2003	The Danish Medical Research Council (DKK 162,000) (scholarship to medical student)
2003	The Danish Diabetes Association (DKK 65,000)
2002	Novo Nordisk Foundation (DKK 100,000)
2002	The Danish Medical Research Council (DKK 1,050,000)
2001	Novo Nordisk Foundation (DKK 100,000)
2001	Novo Nordisk Foundation (DKK 75,000)
2001	The Danish Diabetes Association (DKK 15,000)
2001	The A.P. Møller Foundation for the Advancement of Medical Science (DKK 44,000)
2000	Desirée and Niels Ydes Foundation (DKK 35,000)
1999	The Hørslev Foundation (DKK 100,000)
1998	The Novo Foundation (DKK 27,000)
1996	Eli Lilly's Diabetological Research Foundation (DKK 25,000)
1996	Travel grant from The Danish Medical Research Council (DKK 97,000)
1996	Research fellowship from the Danish Medical Research Council (DKK 385,000)
1995	The Ruth Kønig-Petersens Foundation (DKK 10,000)
1994	Institute of Experimental Clinical Research (DKK 60,000)
1994	The Danish Diabetes Association (DKK 50,000)
1994	Novocare Research Foundation (DKK 25,000)
1994	Novo Nordisk Foundation (DKK 50,000)
1994	The Aage Louis-Hansens Memorial Foundation (DKK 65,000)
1993	Institute of Experimental Clinical Research (DKK 30,000)
1993	The Danish Diabetes Association (DKK 15,000)
1992	Research fellowship from the Danish Medical Research Council (DKK 793,000)
1992	Nordic Insulin Foundation (DKK 15,000)
1991	Scholarship from Sawmill owner Jeppe Juhl and wife Memorial Foundation (DKK 30,000)
1990	Scholarship from Sandoz Pharmaceutical (DKK 60,000)
1990	Scholarship from Novo Nordisk A/S (DKK 60,000)
1989	Scholarship from the Danish Medical Research Council (DKK 50,000)

Publications

Potassium deficiency decreases the capacity for urea synthesis and markedly increases ammonia in rats

Mikkelsen, A. C. D., Thomsen, K. L., Vilstrup, H. V. A., Aamann, L., Jones, H., Mookerjee, R. P., Hamilton-Dutoit, S. J., Frystyk, J. & Aagaard, N. K., jan. 2021, I: American Journal of Physiology: Gastrointestinal and Liver Physiology.

Pregnancy-Associated Plasma Protein-A2 Is Associated With Mortality in Patients With Lung Cancer

Hjortebjerg, R., Espelund, U., Rasmussen, T. R., Folkersen, B., Steiniche, T., Georgsen, J. B., Oxvig, C. & Frystyk, J., sep. 2020, I: Frontiers in Endocrinology. 11, 11 s., 614.

Soluble Klotho: a possible predictor of quality of life in acromegaly patients

Coopmans, E. C., El-Sayed, N., Frystyk, J., Magnusson, N. E., Jørgensen, J. O. L., van der Lely, A-J., Janssen, J. A. M. J. L., Muhammad, A. & Neggers, S. J. C. M. M., jul. 2020, I: Endocrine. 69, 1, s. 165-174 10 s.

Increases in bioactive IGF do not parallel increases in total IGF-I during growth hormone treatment of children born SGA

Wegmann, M. G., Jensen, R. B., Thankamony, A., Frystyk, J., Roche, E., Hoey, H., Kirk, J., Shaikh, G., Ivarsson, S-A., Söder, O., Dunger, D. B. & Juul, A., apr. 2020, I: The Journal of clinical endocrinology and metabolism. 105, 4, dgz118.

Vitamin B12 and its binding proteins in patients with non-small cell lung cancer referred to fast-track diagnostic work-up for lung cancer

Lo-Bisgaard, T., Espelund, U., Frystyk, J., Rasmussen, T. R., Nexo, E. & Arendt, J. F. H., feb. 2020, I: Scandinavian Journal of Clinical & Laboratory Investigation. 80, 1, s. 14-19 6 s.

Development of a novel assay for IGFBP-2 complexed with IGF-I and-II in human serum

Agerholm, J., Hjortebjerg, R., Espelund, U., Rasmussen, T. R., Folkersen, B., Bjerre, M. & Frystyk, J., 2020, I: Growth Hormone and IGF Research. 51, s. 38-45 8 s.

Effects of a highly controlled carbohydrate-reduced high-protein diet on markers of oxidatively generated nucleic acid modifications and inflammation in weight stable participants with type 2 diabetes; a randomized controlled trial

Skytte, M. J., Samkani, A., Astrup, A., Larsen, T. M., Frystyk, J., Poulsen, H. E., Henriksen, T., Holst, J. J., Andersen, O., Madsbad, S., Haugaard, S. B., Krarup, T. & Larsen, E. L., 2020, I: Scandinavian Journal of Clinical and Laboratory Investigation. 80, 5, s. 401-407 7 s.

Increased leptin, decreased adiponectin and FGF21 concentrations in adolescent offspring of women with gestational diabetes

Kampmann, F. B., Thuesen, A. C. B., Hjort, L., Bjerregaard, A. A., Chavarro, J., Frystyk, J., Bjerre, M., Tetens, I., Olsen, S., Vaag, A., Damm, P. & Grunnet, L. G., dec. 2019, I: European Journal of Endocrinology. 181, 6, s. 691-700 10 s.

A carbohydrate-reduced high-protein diet improves HbA1c and liver fat content in weight stable participants with type 2 diabetes: a randomised controlled trial

Skytte, M. J., Samkani, A., Petersen, A. D., Thomsen, M. N., Astrup, A., Chabanova, E., Frystyk, J., Holst, J. J., Thomsen, H. S., Madsbad, S., Larsen, T. M., Haugaard, S. B. & Krarup, T., nov. 2019, I: Diabetologia. 62, 11, s. 2066-2078 13 s.

Effects of short-term prednisolone treatment on indices of lipolysis and lipase signaling in abdominal adipose tissue in healthy humans

Ramshanker, N., Jessen, N., Voss, T. S., Pedersen, S. B., Jørgensen, J. O. L., Nielsen, T. S., Frystyk, J. & Møller, N., okt. 2019, I: Metabolism. 99, s. 1-10

Home-based ‘exergaming’ was safe and significantly improved 6-min walking distance in patients with prostate cancer: a single-blinded randomised controlled trial

Villumsen, B. R., Jorgensen, M. G., Frystyk, J., Hordam, B. & Borre, M., okt. 2019, I: BJU International. 124, 4, s. 600-608 9 s.

PAPP-A activity is increased in cerebrospinal fluid from patients with diabetic polyneuropathy and correlates with peripheral nerve impairment

Kallestrup, M., Frystyk, J., Espelund, U., Hjortebjerg, R., Tankisi, H. & Andersen, H., okt. 2019, I: Growth Hormone and IGF Research. 48-49, s. 53-59 7 s.

The IGF system in patients with inflammatory bowel disease treated with prednisolone or infliximab: potential role of the stanniocalcin-2 / PAPP-A / IGFBP-4 axis

Hjortebjerg, R., Thomsen, K. L., Agnholt, J. & Frystyk, J., jun. 2019, I: BMC Gastroenterology. 19, 11 s., 83.

Analyses of IGFBP2 DNA methylation and mRNA expression in visceral and subcutaneous adipose tissues of obese subjects

Zhang, X., Gu, H. F., Frystyk, J., Efendic, S., Brismar, K. & Thorell, A., apr. 2019, I: Growth Hormone & I G F Research. 45, s. 31-36 6 s.

Uric acid is not associated with diabetic nephropathy and other complications in type 1 diabetes

Pilemann-Lyberg, S., Hansen, T. W., Persson, F., Theilade, S., Singh Ahluwalia, T., Frystyk, J. & Rossing, P., apr. 2019, I: Nephrology, Dialysis, Transplantation. 34, 4, s. 659-666 8 s.

Growth Hormone Signaling and Action in Obese versus Lean Human Subjects

Høgild, M. L., Bak, A. M., Pedersen, S. B., Rungby, J., Frystyk, J., Møller, N., Jessen, N. & Jørgensen, J. O. L., feb. 2019, I: American Journal of Physiology: Endocrinology and Metabolism. 316, 2, s. E333-E344 12 s.

Enhanced anti-metastatic bioactivity of an IGF-TRAP re-engineered to improve physicochemical properties

Vaniotis, G., Moffett, S., Sulea, T., Wang, N., Elahi, S. M., Lessard, E., Baardsnes, J., Perrino, S., Durocher, Y., Frystyk, J., Massie, B. & Brodt, P., 26 nov. 2018, I: Scientific Reports. 8, 1, s. 17361

Comparison of Prognostic Usefulness of Serum Insulin-Like Growth Factor-Binding Protein 7 in Patients With Heart Failure and Preserved Versus Reduced Left Ventricular Ejection Fraction

Hage, C., Bjerre, M., Frystyk, J., Gu, H. F., Brismar, K., Donal, E., Daubert, J-C., Linde, C. & Lund, L. H., 15 jun. 2018, I: The American Journal of Cardiology. 121, 12, s. 1558-1566 9 s.

Prognostic relevance and performance characteristics of serum IGFBP-2 and PAPP-A in women with breast cancer: a long-term Danish cohort study

Espelund, U., Renehan, A. G., Cold, S., Oxvig, C., Lancashire, L., Su, Z., Flyvbjerg, A. & Frystyk, J., jun. 2018, I: Cancer Medicine. 7, 6, s. 2391-2404 14 s.

The effect of growth hormone on bioactive IGF in overweight/obese women

Dichtel, L. E., Bjerre, M., Schorr, M., Bredella, M. A., Gerweck, A. V., Russell, B. M., Frystyk, J. & Miller, K. K., jun. 2018, I: Growth Hormone & I G F Research. 40, s. 20-27 8 s.

Postprandial Mineral Handling in Patients on Maintenance Hemodialysis

Reinhard, M., Frystyk, J., Randers, E., Bibby, B. M. & Ivarsen, P., 1 maj 2018, I: Journal of Renal Nutrition. 28, 3, s. A3-223

Depot-specific and GH-dependent regulation of IGF binding protein-4, pregnancy-associated plasma protein-A, and stanniocalcin-2 in murine adipose tissue

Hjortebjerg, R., Berryman, D. E., Comisford, R., List, E. O., Oxvig, C., Bjerre, M., Frystyk, J. & Kopchick, J. J., apr. 2018, I: Growth Hormone & I G F Research. 39, s. 54-61 8 s.

Growth Hormone Research Society perspective on biomarkers of GH action in children and adults

Johannsson, G., Bidlingmaier, M., Biller, B., Boguszewski, M., Casanueva, F. F., Chanson, P., Clayton, P. E., Choong, C. S., Clemmons, D., Dattani, M., Frystyk, J., Ho, K. K. Y., Hoffman, A., Horikawa, R., Juul, A., Kopchick, J., Luo, X., Neggers, S., Netchine, I., Olsson, D. S., Radovick, S., Rosenfeld, R. G., Ross, R. J., Schilbach, K., Collett-Solberg, P. F., Strasburger, C. J., Trainer, P. J., Yuen, K. C., Wickstrom, K. & Jørgensen, J. O. L., 1 mar. 2018, I: Endocrine Connections. 7, 3, s. R126-R134 18 s.

The effect of uric acid lowering treatment on albuminuria and renal function in Type 1 diabetes:a randomized clinical trial

Pilemann-Lyberg, S., Persson, F., Frystyk, J. & Rossing, P., mar. 2018, I: Diabetic medicine : a journal of the British Diabetic Association. 35, 3, s. 392-393 2 s.

The ZBED6-IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals

Younis, S., Schönke, M., Massart, J., Hjortebjerg, R., Sundström, E., Gustafson, U., Björnholm, M., Krook, A., Frystyk, J., Zierath, J. R. & Andersson, L., feb. 2018, I: Proceedings of the National Academy of Sciences of the United States of America. 115, 9, s. E2048-E2057 12 s.

Effect of Liraglutide on Ectopic Fat in Polycystic Ovary Syndrome: A Randomized Clinical Trial

Frøssing, S., Nylander, M., Chabanova, E., Frystyk, J., Holst, J. J., Kistorp, C., Skouby, S. O. & Faber, J., jan. 2018, I: Diabetes, Obesity and Metabolism. 20, 1, s. 215-218 4 s.

Routine blood tests and probability of cancer in patients referred with non- specific serious symptoms: a cohort study

Næser, E., Møller, H., Fredberg, U., Frystyk, J. & Vedsted, P., 4 dec. 2017, I: BMC Cancer. 17, 817, 11 s.

Pharmacokinetics of IGF-I in PAPP-A2 Deficient Patients, Growth Response, and Effects on Glucose and Bone Density

Cabrera-Salcedo, C., Mizuno, T., Tyzinski, L., Andrew, M., Vinks, A. A., Frystyk, J., Wasserman, H., Gordon, C. M., Hwa, V., Backeljauw, P. & Dauber, A., dec. 2017, I: Journal of Clinical Endocrinology and Metabolism. 201, 12, s. 4568-4577 10 s.

Effects of prednisolone on serum and tissue fluid IGF-I receptor activation and post-receptor signaling in humans

Ramshanker, N., Aagaard, M., Hjortebjerg, R., Voss, T. S., Møller, N., Jørgensen, J. O. L., Jessen, N., Bjerring, P., Magnusson, N. E., Bjerre, M., Oxvig, C. & Frystyk, J., nov. 2017, I: Journal of Clinical Endocrinology and Metabolism. 102, 11, s. 4031-4040 10 s.

Differential impact of glucose administered intravenously and orally on circulating miR-375 levels in human subjects

Yan, X., Wang, Z., Westberg-Rasmussen, S., Tarbier, M., Rathjen, T., Tattikota, S. G., Peck, B. C. E., Kanke, M., Oxvig, C., Frystyk, J., Starup-Linde, J., Sethupathy, P., Friedländer, M. R., Gregersen, S. & Poy, M. N., 1 okt. 2017, I: Journal of Clinical Endocrinology and Metabolism. 102, 10, s. 3749-3755 7 s.

One level up: abnormal proteolytic regulation of IGF activity plays a role in human pathophysiology

Argente, J., Chowen, J. A., Pérez-Jurado, L. A., Frystyk, J. & Oxvig, C., 1 okt. 2017, I: EMBO Molecular Medicine. 9, 10, s. 1338-1345 8 s.

Glucagon Decreases IGF-1 Bioactivity in Humans, Independently of Insulin, by Modulating Its Binding Proteins

Sarem, Z., Bumke-Vogt, C., Mahmoud, A. M., Assefa, B., Weickert, M. O., Adamidou, A., Bähr, V., Frystyk, J., Möhlig, M., Spranger, J., Lieske, S., Birkenfeld, A. L., Pfeiffer, A. F. H. & Arafat, A. M., 1 sep. 2017, I: Journal of Clinical Endocrinology and Metabolism. 102, 9, s. 3480-3490 11 s.

Insulin-Like Growth Factor Bioactivity, Stanniocalcin-2, Pregnancy-Associated Plasma Protein-A, and IGF-Binding Protein-4 in Pleural Fluid and Serum From Patients With Pulmonary Disease

Espelund, U. S., Bjerre, M., Hjortebjerg, R., Rasmussen, T. R., Lundby, A., Hoeflich, A., Folkersen, B. H., Oxvig, C. & Frystyk, J., 1 sep. 2017, I: Journal of Clinical Endocrinology and Metabolism. 102, 9, s. 3526-3534 9 s.

Insulin sensitivity in relation to fat distribution and plasma adipocytokines among abusers of anabolic androgenic steroids

Rasmussen, J. J., Schou, M., Selmer, C., Johansen, M. L., Gustafsson, F., Frystyk, J., Dela, F., Faber, J. & Kistorp, C., sep. 2017, I: Clinical Endocrinology. 87, 3, s. 249-256 8 s.

The timing of administration of exogenous glucocorticoid affects 24hour growth hormone secretion in children

Wolthers, O. D., Ramshanker, N., Heuck, C. & Frystyk, J., aug. 2017, I: Growth Hormone & I G F Research. 35, 1, s. 40-44 5 s.

Abnormal levels of adipokines in adolescent offspring of women with type 1 diabetes - Results from the EPICOM study

Lohse, Z., Bytoft, B., Knorr, S., Clausen, T. D., Beck Jensen, R., Beck-Nielsen, H., Hermann, A. P., Oturai, P., Frystyk, J., Damm, P., Gravholt, C. H., Højlund, K. & Jensen, D. M., jul. 2017, I: Metabolism. 72, s. 47-56 10 s.

Early Pregnancy-Associated Plasma Protein A Concentrations are Associated with Third Trimester Insulin Sensitivity

Petry, C. J., Ong, K. K., Hughes, I. A., Acerini, C. L., Frystyk, J. & Dunger, D. B., 1 jun. 2017, I: Journal of Clinical Endocrinology and Metabolism. 102, 6, s. 2000-2008 9 s.

Insulin, IGF-1, and GH Receptors are Altered in an Adipose Tissue Depot-Specific Manner in Male Mice with Modified GH Action

Hjortebjerg, R., Berryman, D. E., Comisford, R., Frank, S. J., List, E. O., Bjerre, M., Frystyk, J. & Kopchick, J., 1 maj 2017, I: Endocrinology. 158, 5, s. 1406-1418 13 s.

The IGF system in patients with type 2 diabetes: associations with markers of cardiovascular target organ damage

Hjortebjerg, R., Laugesen, E., Høyem, P., Oxvig, C., Stausbøl-Grøn, B., Knudsen, S. T., Kim, W. Y., Poulsen, P. L., Hansen, T. K., Bjerre, M. & Frystyk, J., 1 maj 2017, I: European Journal of Endocrinology. Supplement. 176, 5, s. 521-531 11 s.

Low adiponectin levels at baseline and decreasing adiponectin levels over 10 years of follow-up predict risk of the metabolic syndrome

Lindberg, S., Jensen, J. S., Bjerre, M., Frystyk, J., Flyvbjerg, A., Jeppesen, J. & Mogelvang, R., 1 apr. 2017, I: Diabetes & Metabolism. 43, 2, s. 134-139 5 s.

First-in-man study with a novel PEGylated recombinant human insulin-like growth factor-I

Kletzl, H., Guenther, A., Höflich, A., Höflich, C., Frystyk, J., Staack, R. F., Schick, E., Wandel, C., Bleich, N. & Metzger, F., apr. 2017, I: Growth Hormone & I G F Research. 33, s. 9-16 8 s.

Insulin-Like Growth Factor Binding Protein 4 Fragments Provide Incremental Prognostic Information on Cardiovascular Events in Patients With ST-Segment Elevation Myocardial Infarction

Hjortebjerg, R., Lindberg, S., Pedersen, S., Mogelvang, R., Jensen, J. S., Oxvig, C., Frystyk, J. & Bjerre, M., 17 mar. 2017, I: Journal of the American Heart Association. 6, 3, s. 1-16 17 s., e005358.

Are Changes in Heart Rate Variability During Hypoglycemia Confounded by the Presence of Cardiovascular Autonomic Neuropathy in Patients with Diabetes?

Cichosz, S. L., Frystyk, J., Tarnow, L. & Fleischer, J., feb. 2017, I: Diabetes Technology & Therapeutics. 19, 2, s. 91-95 5 s.

The IGF-Axis and Diabetic Retinopathy Before and After Gastric Bypass Surgery

Brynskov, T., Laugesen, C. S., Floyd, A. K., Frystyk, J. & Sørensen, T. L., feb. 2017, I: Obesity Surgery. 27, 2, s. 408-415 8 s.

36 h fasting of young men influences adipose tissue DNA methylation of LEP and ADIPOQ in a birth weight-dependent manner

Hjort, L., Jørgensen, S. W., Gillberg, L., Hall, E., Brøns, C., Frystyk, J., Vaag, A. & Ling, C., 2017, I: Clinical Epigenetics (Print). 9, s. 40-51

IGF-1, IGFBP-3 and insulin sensitivity during weight loss in children.

Birkebæk, N., Grønbæk, H., Lange, A., Holland-Fischer, P., Kristensen, K., Rittig, S., Vilstrup, H. & Frystyk, J., 2017, I: Hormone Research in Paediatrics. 88, 1, s. 1108

SERUM STANNIOCALCIN (STC) 2 LEVELS ARE INCREASED IN PREPUBERTAL OBESE CHILDREN

Noer, P. R., Guerra-Cantero, S., Barrios, V., Martos-Moreno, G. A., Vila-Dupla, S., Chowen, J. A., Frystyk, J., Oxvig, C. & Argente, J., 2017, I: Hormone Research in Paediatrics. 88, Supplement 1, s. 285-286 2 s.

Markers of oxidative stress in obese men with and without hypertension

Cejvanovic, V., Asferg, C., Kjær, L. K., Andersen, U. B., Linneberg, A., Frystyk, J., Henriksen, T., Flyvbjerg, A., Christiansen, M., Weimann, A., Jeppesen, J. & Poulsen, H. E., dec. 2016, I: Scandinavian Journal of Clinical & Laboratory Investigation. 76, 8, s. 620-625 6 s.

Growth Hormone and Insulin Signaling in Acromegaly: Impact of Surgery versus Somatostatin Analog Treatment

Dal, J., Lundby Høyer, K., Pedersen, S. B., Erik Magnusson, N., Bjerring, P., Frystyk, J., Møller, N., Jessen, N. & Otto Lunde Jørgensen, J., okt. 2016, I: Endocrinology. 101, 10, s. 3716-3723 8 s.

Growth Hormone Research Society perspective on the development of long-acting growth hormone preparations

Christiansen, J. S., Backeljauw, P. F., Bidlingmaier, M., Biller, B. M. K., Boguszewski, M. C. S., Casanueva, F. F., Chanson, P., Chatelain, P., Choong, C. S., Clemmons, D. R., Cohen, L. E., Cohen, P., Frystyk, J., Grimberg, A., Hasegawa, Y., Haymond, M. W., Ho, K., Hoffman, A. R., Holly, J. M. P., Horikawa, R., Höybye, C., Jørgensen, J. O. L., Johannsson, G., Juul, A., Katznelson, L., Kopchick, J. J., Lee, K. O., Lee, K-W., Luo, X., Melmed, S., Miller, B. S., Misra, M., Popovic, V., Rosenfeld, R. G., Ross, J., Ross, R. J., Saenger, P., Strasburger, C. J., Thorner, M. O., Werner, H. & Yuen, K., jun. 2016, I: European journal of endocrinology / European Federation of Endocrine Societies. 174, 6, s. C1-8 9 s.

Pegvisomant-primed glucagon stimulation test in assessing GH reserve and GH/IGF kinetics in adults suspected of GH deficiency

Yuen, K. C. J., Frystyk, J., Rhoads, S. A. & Bidlingmaier, M., 1 feb. 2016, I: Pituitary. 19, 1, s. 65-74 10 s.

Macrophage activation marker soluble CD163 may predict disease progression in hepatocellular carcinoma

Kazankov, K., Rode, A., Simonsen, K. S., Villadsen, G. E., Nicoll, A., Møller, H. J., Lim, L., Angus, P., Kronborg, I., Arachchi, N., Gorelik, A., Liew, D., Vilstrup, H., Frystyk, J. & Grønbæk, H., feb. 2016, I: Scandinavian Journal of Clinical & Laboratory Investigation. 76, 1, s. 64-73 10 s.

Similar Adiponectin Levels in Obese Normotensive and Obese Hypertensive Men and No Vasorelaxant Effect of Adiponectin on Human Arteries

Dreier, R., Asferg, C., Berg, J. O., Andersen, U. B., Flyvbjerg, A., Frystyk, J., Linneberg, A., Jeppesen, J. L., Edvinsson, L. & Skovsted, G. F., feb. 2016, I: Basic & Clinical Pharmacology & Toxicology. 118, 2, s. 128-35 8 s.

Adiponectin and leptin in children with type 1 diabetes for 3-5 years with or without residual β cell function.

Birkebæk, N., Sørensen, J. S., Kristensen, K., Pociot, F. & Frystyk, J., 2016, I: Hormone Research in Paediatrics. s. 83

Differences in Adiponectin, Leptin and Leptin to Adiponectin Ratio in Adolescent Offspring of Women with Type 1 Diabetes – Results from the EPICOM Study

Lohse, Z., Bytoft, B., Knorr, S., Clausen, T. D., Jensen, R. B., Frystyk, J., Oturai, P. S., Hermann, A. P., Beck-Nielsen, H., Gravholt, C. H., Damm, P., Højlund, K. & Jensen, D. M., 2016.

Increase in sclerostin after rapid weight loss in children.

Birkebæk, N., Frystyk, J., Lange, A., Holland-Fischer, P. H., Kristensen, K., Rittig, S., Vilstrup, H. & Grønbæk, H., 2016, I: Hormone Research in Paediatrics. 86, s. 167

Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability

Dauber, A., Muñoz-Calvo, M. T., Barrios, V., Domené, H. M., Kloverpris, S., Serra-Juhé, C., Desikan, V., Pozo, J., Muzumdar, R., Martos-Moreno, G. Á., Hawkins, F., Jasper, H. G., Conover, C. A., Frystyk, J., Yakar, S., Hwa, V., Chowen, J. A., Oxvig, C., Rosenfeld, R. G., Pérez-Jurado, L. A. & Argente, J., 2016, I: E M B O Reports. 8, 4, s. 363-74 12 s.

PAPP-A, IGFBP-4 and IGF-II are secreted by human adipose tissue cultures in a depot-specific manner

Gude, M. F., Hjortebjerg, R., Oxvig, C., Thyø, A. A., Magnusson, N. E., Bjerre, M., Pedersen, S. B. & Frystyk, J., 2016, I: European Journal of Endocrinology. 175, 6, s. 509-519 11 s.

Response of fibroblast growth factor 23 to a phosphate-rich meal

Reinhard, M., Frystyk, J., Jespersen, B. & Ivarsen, P., 2016.

Treatment with recombinant human insulin-like growth factor-I improves growth in patients with PAPP-A2 deficiency

Teresa Muñoz-Calvo, M., Barrios, V., Pozo, J., Chowen, J. A., Martos-Moreno, G. Á., Hawkins, F., Dauber, A., Domené, H. M., Yakar, S., Rosenfeld, R. G., Pérez-Jurado, L. A., Oxvig, C., Frystyk, J. & Argente, J., 2016, I: The Journal of Clinical Endocrinology & Metabolism. 101, 11, s. 3879-3883 5 s.

Tissue IGF-I Measured by Microdialysis Reflects Body Glucose Utilization After rhIGF-I Injection in Type 1 Diabetes

Ekström, K., Pulkkinen, M-A., Carlsson-Skwirut, C., Brorsson, A-L., Ma, Z., Frystyk, J. & Bang, P., 15 nov. 2015, I: Endocrinology. 100, 11, s. 4299-306 8 s.

Adiponectin, type 2 diabetes and cardiovascular risk

Lindberg, S., Jensen, J. S., Bjerre, M., Haahr-Pedersen, S. A., Frystyk, J., Flyvbjerg, A., Galatius, S., Jeppesen, J. & Mogelvang, R., 1 nov. 2015, I: European Journal of Preventive Cardiology. 22, 3, s. 276-83 8 s.

Differential effects of low birthweight and intrauterine growth restriction on umbilical cord blood insulin-like growth factor concentrations

Tzschoppe, A., Riedel, C., von Kries, R., Struwe, E., Rascher, W., Dörr, H. G., Beckmann, M. W., Schild, R. L., Goecke, T. W., Flyvbjerg, A., Frystyk, J. & Dötsch, J., 1 nov. 2015, I: Clinical Endocrinology. 83, 5, s. 739-45 7 s.

Interplay Between Adiponectin and Pro-Atrial Natriuretic Peptide and Prognosis in Patients With ST-Segment Elevation Myocardial Infarction

Lindberg, S., Jensen, J. S., Hoffmann, S., Pedersen, S. H., Iversen, A. Z., Galatius, S., Frystyk, J., Flyvbjerg, A., Goetze, J. P., Bjerre, M. & Mogelvang, R., 1 nov. 2015, I: The American Journal of Cardiology. 116, 9, s. 1340-5 6 s.

Enhanced insulin signaling in human skeletal muscle and adipose tissue following gastric bypass surgery

Albers, P. H., Bojsen-Møller, K. N., Dirksen, C., Serup, A. K., Kristensen, D. E., Frystyk, J., Clausen, T. R., Kiens, B., Richter, E. A., Madsbad, S. & Wojtaszewski, J. F. P., sep. 2015, I: A J P: Regulatory, Integrative and Comparative Physiology (Online). 309, 5, s. R510-24 15 s.

PAPP-A proteolytic activity enhances IGF bioactivity in ascites from women with ovarian carcinoma

Thomsen, J., Hjortebjerg, R., Espelund, U., Ørtoft, G., Vestergaard, P., Magnusson, N. E., Conover, C. A., Tramm, T., Hager, H., Høgdall, C., Høgdall, E., Oxvig, C. & Frystyk, J., 24 aug. 2015, I: OncoTarget. 6, 31, s. 32266-32278 13 s.

IGFBP-4 fragments as markers of cardiovascular mortality in type 1 diabetes patients with and without nephropathy

Hjortebjerg, R., Tarnow, L., Jorsal, A., Parving, H-H., Rossing, P., Bjerre, M. & Frystyk, J., 1 aug. 2015, I: Journal of Clinical Endocrinology and Metabolism. s. 3032-40 8 s.

Digital histology quantification of intra-hepatic fat in patients undergoing liver resection

Parkin, E., O'Reilly, D. A., Plumb, A. A., Manoharan, P., Rao, M., Coe, P., Frystyk, J., Ammori, B., de Liguori Carino, N., Deshpande, R., Sherlock, D. J. & Renehan, A. G., aug. 2015, I: European Journal of Surgical Oncology. 41, 8, s. 1020-7 8 s.

Response of fibroblast growth factor 21 to meal intake and insulin infusion in patients on maintenance haemodialysis

Reinhard, M., Frystyk, J., Jespersen, B., Randers, E., Bibby, B. M. & Ivarsen, P., aug. 2015, I: Clinical Endocrinology. 83, 2, s. 187-95 9 s.

The Circulating IGF System in Hepatocellular Carcinoma: The Impact of Liver Status and Treatment

Espelund, U., Grønbæk, H., Villadsen, G. E., Simonsen, K., Vestergaard, P. F., Jørgensen, J. O. L., Flyvbjerg, A., Vilstrup, H. & Frystyk, J., aug. 2015, I: Growth Hormone & I G F Research. 25, 4, s. 174-81 8 s.

Exercise Addiction in Men Is Associated With Lower Fat-Adjusted Leptin Levels

Lichtenstein, M. B., Andries, A., Hansen, S., Frystyk, J. & Støving, R. K., 1 mar. 2015, I: Clinical Journal of Sport Medicine. 25, 1, s. 138-43 5 s.

PAPP-A and IGFBP-4 fragment levels in patients with ST-elevation myocardial infarction treated with heparin and PCI

Hjortebjerg, R., Lindberg, S., Jensen, J. S., Oxvig, C., Bjerre, M. & Frystyk, J., mar. 2015, I: Clinical Biochemistry. 148, 4-5, s. 322-328 7 s.

Changes in IGF-I, urinary free cortisol and adipokines during dronabinol therapy in anorexia nervosa: Results from a randomised, controlled trial

Andries, A., Frystyk, J., Flyvbjerg, A. & Støving, R. K., 2015, I: Growth Hormone & I G F Research. 25, 5, s. 247-52 6 s.

Combining Information of Autonomic Modulation and CGM Measurements Enables Prediction and Improves Detection of Spontaneous Hypoglycemic Events

Cichosz, S. L., Frystyk, J., Tarnow, L. & Fleischer, J., 2015, I: Journal of Diabetes Science and Technology. 9, 1, s. 132-7

The effects of capillary dysfunction on oxygen and glucose extraction in diabetic neuropathy

Østergaard, L., Finnerup, N. B., Terkelsen, A. J., Olesen, R. A., Drasbek, K. R., Knudsen, L., Jespersen, S. N., Frystyk, J., Charles, M., Thomsen, R. W., Christiansen, J. S., Beck-Nielsen, H., Jensen, T. S. & Andersen, H., 2015, I: Diabetologia. 58, 4, s. 666-677 12 s.

Residual β-cell function and the insulin-like growth factor system in Danish children and adolescents with type 1 diabetes

Sorensen, J. S., Birkebaek, N. H., Bjerre, M., Pociot, F., Kristensen, K., Hoejberg, A. S., Frystyk, J. & Danish Society for Diabetes in Childhood and Adolescence, 22 dec. 2014, I: Journal of Clinical Endocrinology and Metabolism. 100, 3, s. 1053-1061 9 s.

Low adiponectin levels and increased risk of type 2 diabetes in patients with myocardial infarction

Lindberg, S., Jensen, J. S., Pedersen, S. H., Galatius, S., Frystyk, J., Flyvbjerg, A., Bjerre, M. & Mogelvang, R., nov. 2014, I: Diabetes Care. 37, 11, s. 3003-8 6 s.

Short-term, low-dose GH therapy improves insulin sensitivity without modifying cortisol metabolism and ectopic fat accumulation in adults with GH deficiency

Yuen, K. C. J., Roberts, C. T., Frystyk, J., Rooney, W. D., Pollaro, J. R., Klopfenstein, B. J. & Purnell, J. Q., okt. 2014, I: Journal of Clinical Endocrinology and Metabolism. 99, 10, s. E1862-9

Cardio-adipose tissue cross-talk: relationship between adiponectin, plasma pro brain natriuretic peptide and incident heart failure

Lindberg, S., Jensen, J. S., Bjerre, M., Pedersen, S. H., Frystyk, J., Flyvbjerg, A. & Mogelvang, R., jun. 2014, I: European Journal of Heart Failure. 16, 6, s. 633-8 6 s.

Impaired postprandial response of the insulin-like growth factor system in maintenance haemodialysis

Reinhard, M., Frystyk, J., Jespersen, B., Randers, E., Bjerre, M., Christiansen, J. S., Flyvbjerg, A., Bibby, B. M. & Ivarsen, P., maj 2014, I: Clinical Endocrinology. 80, 5, s. 757-65 9 s.

IGF-I and IGFBP2 in peripheral artery disease: results of a prospective study

Urbonaviciene, G., Frystyk, J., Urbonavicius, S. & Lindholt, J. S., apr. 2014, I: Scandinavian Cardiovascular Journal. 48, 2, s. 99-105 7 s.

IGFALS gene dosage effects on serum IGF-I and glucose metabolism, body composition, bone growth in length and width, and the pharmacokinetics of recombinant human IGF-I administration

Högler, W., Martin, D. D., Crabtree, N., Nightingale, P., Tomlinson, J., Metherell, L., Rosenfeld, R., Hwa, V., Rose, S., Walker, J., Shaw, N., Barrett, T. & Frystyk, J., apr. 2014, I: Journal of Clinical Endocrinology and Metabolism. 99, 4, s. E703-12

A Novel Algorithm for Prediction and Detection of Hypoglycemia Based on Continuous Glucose Monitoring and Heart Rate Variability in Patients With Type 1 Diabetes

Cichosz, S. L., Frystyk, J., Hejlesen, O. K., Tarnow, L. & Fleischer, J., 31 mar. 2014, I: Journal of Diabetes Science and Technology.

Effects of raloxifene and estrogen on bioactive IGF1 in GH-deficient women

Birzniece, V., Magnusson, N. E., Ho, K. K. Y. & Frystyk, J., mar. 2014, I: European journal of endocrinology / European Federation of Endocrine Societies. 170, 3, s. 375-83 9 s.

Insulin growth factor binding proteins as therapeutic targets in type 2 diabetes

Hjortebjerg, R., Flyvbjerg, A. & Frystyk, J., feb. 2014, I: Expert Opinion On Therapeutic Targets. 18, 2, s. 209-24 16 s.

GLP-1 infusion reduces IGFBP-1 serum level in humans

Skov, J., Frystyk, J. & Christiansen, J. S., 18 jan. 2014, I: Growth Hormone & I G F Research. 24, 2-3, s. 67-70 4 s.

Cross-talk between the heart and adipose tissue in cachectic heart failure patients with respect to alterations in body composition: a prospective study

Christensen, H. M., Kistorp, C. M. N., Schou, M., Keller, N., Zerahn, B., Frystyk, J., Flyvbjerg, A. & Faber, J., jan. 2014, I: Metabolism. 63, 1, s. 141-9 9 s.

Prednisolone but not infliximab aggravates the upregulated hepatic nitrogen elimination in patients with active inflammatory bowel disease

Thomsen, K. L., Grønbæk, H., Dahlerup, J. F., Aagaard, N. K., Christensen, L. A., Agnholt, J., Frystyk, J. & Vilstrup, H., jan. 2014, I: Inflammatory Bowel Diseases. 20, 1, s. 7-13 7 s.

Prevalence of posttraumatic growth hormone deficiency is highly dependent on the diagnostic set-up: results from The Danish National Study on Posttraumatic Hypopituitarism

Klose, M., Krag, K. S., Janukonyté, J., Lehman Christensen, L., Frystyk, J., Andersen, M., Laurberg, P., Christiansen, J. S. & Feldt-Rasmussen, U., jan. 2014, I: Journal of Clinical Endocrinology and Metabolism. 99, 1, s. 101-10 10 s.

An homologous model of gene therapy by in vivoadministration of a plasmid containing the mouse growth hormone gene in immunocompetentdwarf mice

Cecchi, C. R., Dagnæs-Hansen, F., Aagaard, L., Jakobsen, M. V., Gissel, H., Gothelf, A. B. V., Hansen, B. H., Frystyk, J., Higuti, E., Oliveira, N. A. J., Lima, E. R., Bartolini, P., Jensen, T. G. & Peroni, C. N., 2014.

Effects of human insulin and insulin aspart preparations on levels of IGF-I, IGFBPs and IGF bioactivity in patients with type 1 diabetes

Ma, Z., Christiansen, J. S., Laursen, T., Wu, C., Lauritzen, T., Parkner, T. & Frystyk, J., 2014, I: B M C Endocrine Disorders. 14, 35, 11 s.

Impact of moderate interval exercise versus supine rest on the pharmacokinetics and pharmacodynamic profiles of subcutaneously administered growth hormone in adult growth hormone deficient patients

Janukonyte, J., Parkner, T., Lauritzen, T., Christiansen, J. S., Frystyk, J., Pedersen, H. S. & Laursen, T., 2014, I: Growth Hormone & I G F Research. 24, 5, s. 198-204 7 s.

Letter to the editor concerning "Elevated serum antibodies against insulin-like growth factor-binding protein-2 allow detecting early-stage cancers: evidences from glioma and colorectal carcinoma studies"

Hassan, W. A., Bjerre, M., Hjortebjerg, R., Magnusson, N. E., Ramshanker, N. & Frystyk, J., 2014, I: Annals of Oncology. 26, 1, s. 252 3 s.

Reference intervals for insulin-like growth factor-1 (igf-i) from birth to senescence: results from a multicenter study using a new automated chemiluminescence IGF-I immunoassay conforming to recent international recommendations

Bidlingmaier, M., Friedrich, N., Emeny, R. T., Spranger, J., Wolthers, O. D., Roswall, J., Körner, A., Obermayer-Pietsch, B., Hübener, C., Dahlgren, J., Frystyk, J., Pfeiffer, A. F. H., Doering, A., Bielohuby, M., Wallaschofski, H. & Arafat, A. M., 2014, I: Journal of Clinical Endocrinology and Metabolism. 99, 5, s. 1712-21 10 s.

Relationship between insulin-like growth factor I levels, early insulin treatment, and clinical outcomes of very low birth weight infants

Beardsall, K., Vanhaesebrouck, S., Frystyk, J., Ogilvy-Stuart, A. L., Vanhole, C., van Weissenbruch, M., Midgley, P., Thio, M., Cornette, L., Gill, B., Ossuetta, I., Iglesias, I., Theyskens, C., de Jong, M., Ahluwalia, J. S., de Zegher, F., Dunger, D. B. & NIRTURE Study Group, 2014, I: The Journal of Pediatrics. 164, 5, s. 1038-1044.e1 7 s.

Short-term effects of NPH insulin, insulin detemir, and insulin glargine on the GH-IGF1-IGFBP axis in patients with type 1 diabetes

Ma, Z., Christiansen, J. S., Laursen, T., Lauritzen, T. & Frystyk, J., 2014, I: European Journal of Endocrinology. 171, 4, s. 471-9 9 s.

The effect of meals and insulin on fibroblast growth factor 21 in maintenance hemodialysis patients

Reinhard, M., Frystyk, J., Jespersen, B., Randers, E. & Ivarsen, P., 2014.

Determination of IGFs and their binding proteins

Hjortebjerg, R. & Frystyk, J., dec. 2013, I: Best Practice & Research: Clinical Endocrinology & Metabolism. 27, 6, s. 771-81 11 s.

Dronabinol in severe, enduring anorexia nervosa: A randomized controlled trial

Andries, A., Frystyk, J., Flyvbjerg, A. & Støving, R. K., 14 sep. 2013, I: International Journal of Eating Disorders. 47, 1, s. 18-23 6 s.

Intraperitoneal insulin delivery to patients with type 1 diabetes results in higher serum IGF-I bioactivity than continuous subcutaneous insulin infusion

Hedman, C. A., Frystyk, J., Lindström, T., Oskarsson, P. & Arnqvist, H. J., 18 jul. 2013, I: Clinical Endocrinology. 81, 1, s. 58-62

Growth hormone (GH) activity is associated with increased serum oestradiol and reduced Anti-Müllerian Hormone in healthy male volunteers treated with GH and a GH antagonist

Andreassen, M., Frystyk, J., Faber, J., Kristensen, L. Ø. & Juul, A., jul. 2013, I: Andrology. 1, 4, s. 595-601 7 s.

Plasma adiponectin in heart failure with and without cachexia: Catabolic signal linking catabolism, symptomatic status, and prognosis

Szabó, T., Scherbakov, N., Sandek, A., Kung, T., von Haehling, S., Lainscak, M., Jankowska, E. A., Rudovich, N., Anker, S. D., Frystyk, J., Flyvbjerg, A., Pfeiffer, A. F. H. & Doehner, W., 18 jun. 2013, I: Nutrition, Metabolism & Cardiovascular Diseases. 24, 1, s. 50-56 7 s.

Changes in calcitropic hormones, bone markers and insulin-like growth factor I (IGF-I) during pregnancy and postpartum: a controlled cohort study

Møller, U. K., við Streym, S., Mosekilde, L., Heickendorff, L., Flyvbjerg, A., Frystyk, J., Jensen, L. T. & Rejnmark, L., apr. 2013, I: Osteoporosis International. 24, 4, s. 1307-20 14 s.

Body mass index in chronic heart failure: association with biomarkers of neurohormonal activation, inflammation and endothelial dysfunction

Christensen, H. M., Schou, M., Goetze, J. P., Faber, J., Frystyk, J., Flyvbjerg, A. & Kistorp, C. M. N., 2013, I: B M C Cardiovascular Disorders. 13, s. 80

Circulating insulin-like growth factors may contribute substantially to insulin receptor isoform A and insulin receptor isoform B signalling

Varewijck, A. J., Brugts, M. P., Frystyk, J., Goudzwaard, J. A., Uitterlinden, P., Waaijers, A. M., Feng, Y., Dimitrov, D. S., Lamberts, S. W. J., Hofland, L. J. & Janssen, J. A. M. J. L., 2013, I: Molecular and Cellular Endocrinology. 365, 1, s. 17-24 8 s.

Effect of hyperinsulinemia during hemodialysis on the insulin-like growth factor system and inflammatory biomarkers: a randomized open-label crossover study

Reinhard, M., Frystyk, J., Jespersen, B., Bjerre, M., Christiansen, J. S., Flyvbjerg, A. & Ivarsen, P., 2013, I: B M C Nephrology. 14, s. 80

Evaluating Haptocorrin as a Lung Function Biomarker

Eriksen, T-L., Arendt, J. F. B., Espelund, U., Samson, M. H., Frystyk, J. & Nexø, E., 2013.

Evaluation of IGFBP-7 DNA methylation changes and serum protein variation in Swedish subjects with and without type 2 diabetes

Gu, H. F., Gu, T., Hilding, A., Zhu, Y., Kärvestedt, L., Ostenson, C-G., Lai, M., Kutsukake, M., Frystyk, J., Tamura, K. & Brismar, K., 2013, I: Clinical Epigenetics. 5, 1, s. 20

Osteoprotegerin improves risk detection by traditional cardiovascular risk factors and hsCRP

Mogelvang, R., Haahr-Pedersen, S. A., Bjerre, M., Frystyk, J., Iversen, A., Galatius, S., Flyvbjerg, A. & Jensen, J. S., 2013, I: Heart. 99, 2, s. 106-10 5 s.

Relation of Serum Adiponectin Levels to Number of Traditional Atherosclerotic Risk Factors and All-Cause Mortality and Major Adverse Cardiovascular Events (from the Copenhagen City Heart Study)

Lindberg, S., Mogelvang, R., Pedersen, S. H., Bjerre, M., Frystyk, J., Flyvbjerg, A., Galatius, S. & Jensen, J. S., 2013, I: American Journal of Cardiology. 111, 8, s. 1139-45 7 s.

Serum levels of bioactive IGF1 and physiological markers of ageing in healthy adults

Vestergaard, P. F., Hansen, M., Frystyk, J., Espelund, U., Christiansen, J. S., Jørgensen, J. O. L. & Fisker, S., 2013, I: European journal of endocrinology / European Federation of Endocrine Societies. 170, 2, s. 229-36 8 s.

Urinary adiponectin excretion rises with increasing albuminuria in type 1 diabetes

Jorsal, A., Petersen, E. H., Tarnow, L., Hess, G., Zdunek, D., Frystyk, J., Flyvbjerg, A., Lajer, M. S. & Rossing, P., 2013, I: Journal of Diabetes and its Complications. 27, 6, s. 604-8 5 s.

The production and regulation of IGF and IGFBPs in human adipose tissue cultures

Gude, M. F., Frystyk, J., Flyvbjerg, A., Bruun, J. M., Richelsen, B. & Pedersen, S. B., dec. 2012, I: Growth Hormone & I G F Research. 22, 6, s. 200-205 6 s.

Effect of Insulin Infusion on Insulin-like Growth Factor I during Hemodialysis

Reinhard, M., Frystyk, J., Jespersen, B. & Ivarsen, P., 3 nov. 2012. 1 s.

Postprandial Mineral Metabolism in Hemodialysis Patients

Reinhard, M., Frystyk, J., Jespersen, B. & Ivarsen, P., 3 nov. 2012.

Effect of Insulin Infusion on insulin-like growth factor I (IGF-I) during Hemodialysis

Reinhard, M., Frystyk, J., Bjerre, M., Christiansen, J. S., Flyvbjerg, A., Jespersen, B. & Ivarsen, P., 28 apr. 2012.

Insulin-like growth factor I receptor density on CD4+T-lymphocytes from active early steroid- and DMARD-naïve rheumatoid arthritis patients is up-regulated and not influenced by 1 year of clinically effective treatment

Laurberg, T. B., Ellingsen, T., Thorsen, J., Møller, B. K., Hansen, I., Tarp, U., Hetland, M. L., Hørslev-Petersen, K., Flyvbjerg, A., Frystyk, J. & Stengaard-Pedersen, K., 19 jan. 2012, I: Rheumatology International. 32, 2, s. 501 504 s.

A comparison of pharmacokinetics and pharmacodynamics of insulin aspart, biphasic insulin aspart 70, biphasic insulin aspart 50, and human insulin: a randomized, quadruple crossover study

Ma, Z., Parkner, T., Frystyk, J., Laursen, T., Lauritzen, T. & Christiansen, J. S., 2012, I: Diabetes Technology & Therapeutics. 14, 7, s. 589-95 7 s.

Adiponectin and its globular fragment differentially modulate the oxidative burst of primary human phagocytes

Chedid, P., Hurtado-Nedelec, M., Marion-Gaber, B., Bournier, O., Hayem, G., Gougerot-Pocidalo, M-A., Frystyk, J., Flyvbjerg, A., El Benna, J. & Marie, J-C., 2012, I: American Journal of Pathology. 180, 2, s. 682-92 11 s.

An homologous model of gene therapy by in vivo administration of a plasmid containing the mouse growth hormone gene in immunocompetent dwarf mice

Cecchi, C. R., Dagnæs-Hansen, N. F., Aagaard, L., Jakobsen, M. V., Gissel, H., Gothelf, A. B., Hansen, B. H., Frystyk, J., Higuti, E., Oliveira, N. A. J., Lima, E. R., Bartolini, P., Jensen, T. G. & Peroni, C. N., 2012.

Bioactive IGF-I and IGFBP-1 in Danish children and adolescents 3 to 5 years after onset of type 1 diabetes. Effect of residual β-cell function

Frystyk, J., Sørensen, J. S., Bjerre, M. & Birkebæk, N., 2012.

Changes in adipokines after transjugular intrahepatic porto-systemic shunt indicate an anabolic shift in metabolism

Thomsen, K. L., Sandahl, T. D., Holland-Fischer, P., Jessen, N., Frystyk, J., Flyvbjerg, A., Grønbæk, H. & Vilstrup, H., 2012, I: Clinical Nutrition.

Changes in calcitropic hormones, bone markers and insulin-like growth factor I (IGF-I) during pregnancy and postpartum: a controlled cohort study.

Liendgaard, U. K. M., við Streym, S., Mosekilde, L., Heickendorff, L., Flyvbjerg, A., Frystyk, J., Jensen, L. T. & Rejnmark, L., 2012, I: Osteoporosis International. 24, 4, s. 1307-1320

Characterisation of adiponectin multimers and the IGF axis in humans with a heterozygote mutation in the tyrosine kinase domain of the insulin receptor gene

Højlund, K., Beck-Nielsen, H., Flyvbjerg, A. & Frystyk, J., 2012, I: European Journal of Endocrinology. 166, 3, s. 511-9 9 s.

Comparison of osteoprotegerin to traditional atherosclerotic risk factors and high-sensitivity C-reactive protein for diagnosis of atherosclerosis

Mogelvang, R., Pedersen, S. H., Flyvbjerg, A., Bjerre, M., Iversen, A., Galatius, S., Frystyk, J. & Jensen, J. S., 2012, I: American Journal of Cardiology. 109, 4, s. 515-20 6 s.

Effects of transdermal estrogen on collagen turnover at rest and in response to exercise in postmenopausal women

Pingel, J., Langberg, H., Skovgård, D., Koskinen, S. O. A., Flyvbjerg, A., Frystyk, J., Kjær, M. & Hansen, M., 2012, I: Journal of Applied Physiology. 113, 7, s. 1040-7 8 s.

Fat Content in Liver and Skeletal Muscle Changes in a Reciprocal Manner in Patients with Acromegaly during Combination Therapy with a Somatostatin Analog and a GH Receptor Antagonist: A Randomized Clinical Trial

Madsen, M., Hafstrøm, T. K., Møller, L., Christensen, B., Vendelbo, M. H., Pedersen, S. B., Frystyk, J., Jessen, N., Hansen, T. K., Stødkilde-Jørgensen, H., Flyvbjerg, A. & Jørgensen, J. O. L., 2012, I: Journal of Clinical Endocrinology and Metabolism.

Growth hormone activity and markers of inflammation - a cross-over study in healthy volunteers treated with growth hormone and a growth hormone receptor antagonist

Andreassen, M., Frystyk, J., Faber, J. & Kristensen, L. Ø., 2012, I: European Journal of Endocrinology. Supplement. 166, 5, s. 811-19 8 s.

Interstitial fluid contains higher in vitro IGF bioactivity than serum: A study utilizing the suction blister technique

Espelund, U., Søndergaard, K., Bjerring, P., Flyvbjerg, A. & Frystyk, J., 2012, I: Growth Hormone & I G F Research.

Local administration of growth hormone stimulates tendon collagen synthesis in elderly men

Nielsen, P. V., Jørgensen, J. O. L., Olesen, J. L., Bosnjak, E., Holm, L., Frystyk, J., Langberg, H., Kjaer, M. & Hansen, M., 2012, I: Journal of Applied Physiology. 113, 9, s. 1432-8 7 s.

Measurement of free GH and bioactive IGF-I in non-diabetic haemodialysis patients treated with GH for 7 days

Frystyk, J., Djurhuus, C. B., Johansen, T., Lange, M., Smidt, K. & Christiansen, J. S., 2012, I: Nephrology, Dialysis, Transplantation. 27, 11, s. 4211-8 8 s.

Novel cardiovascular risk markers in depression: No association between depressive symptoms and osteoprotegerin or adiponectin in persons at high risk for sleep apnea

Einvik, G., Flyvbjerg, A., Hrubos-Strøm, H., Randby, A., Frystyk, J., Bjerre, M., Namtvedt, S. K., Kristiansen, H. A., Nordhus, I. H., Somers, V. K., Dammen, T. & Omland, T., 2012, I: Journal of Affective Disorders.

Osteoprotegerin predicts long-term outcome in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention

Pedersen, S. F., Bjerre, M., Mogelvang, R., Frystyk, J., Flyvbjerg, A., Galatius, S., Sørensen, T. B., Iversen, A., Hvelplund, A. & Jensen, J. S., 2012, I: Cardiology. 123, 1, s. 31-8 8 s.

Positive associations between serum levels of IGF-I and subcutaneous fat depots in young men. The Odense Androgen Study

Andersen, M., Brixen, K., Hagen, C., Frystyk, J. & Nielsen, T. L., 2012, I: Growth Hormone & IGF Research. 22, 3-4, s. 139-45 7 s.

Prednisolone reduces the ability of serum to activate the IGF-I receptor in vitro without affecting circulating total or free IGF-I

Frystyk, J., Schou, A. J., Heuck, C., Vorum, H., Lyngholm, J. M., Flyvbjerg, A. & Wolthers, O. D., 2012, I: European Journal of Endocrinology.

Prevalence of cachexia in chronic heart failure and characteristics of body composition and metabolic status

Christensen, H. M., Kistorp, C. M. N., Schou, M., Keller, N., Zerahn, B., Frystyk, J., Schwarz, P. & Faber, J., 2012, I: Endocrine. 43, 3, s. 626-34

Quantification of the GH/IGF-axis components: lessons from human studies

Frystyk, J., 2012, I: Domestic Animal Endocrinology. 43, 2, s. 186-97 12 s.

Testosterone therapy decreases subcutaneous fat and adiponectin in aging men

Frederiksen, L., Højlund, K., Hougaard, D. M., Mosbech, T. H., Larsen, R., Flyvbjerg, A., Frystyk, J., Brixen, K. & Andersen, M., 2012, I: European Journal of Endocrinology. 166, 3, s. 469-76 8 s.

The effect of prolonged fasting on levels of growth hormone-binding protein and free growth hormone

Salgin, B., Marcovecchio, M. L., Hill, N., Dunger, D. B. & Frystyk, J., 2012, I: Growth Hormone & IGF Research. 22, 2, s. 76 81 s.

Usefulness of Adiponectin as a Predictor of All Cause Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention

Lindberg, S., Pedersen, S. H., Møgelvang, R., Bjerre, M., Frystyk, J., Flyvbjerg, A., Galatius, S. & Jensen, J. S., 2012, I: American Journal of Cardiology. 109, 4, s. 492-6 5 s.

α-Defensins and outcome in patients with chronic heart failure

Christensen, H. M., Frystyk, J., Faber, J., Schou, M., Flyvbjerg, A., Hildebrandt, P., Raymond, I. E., Klausen, T. W. & Kistorp, C. M. N., 2012, I: European Journal of Heart Failure. 14, 4, s. 387-94 8 s.

IL-6 has no acute effect on the regulation of urea synthesis in vivo in rats

Thomsen, K. L., Aagaard, N. K., Grønbæk, H., Holst, J. J., Jessen, N., Frystyk, J. & Vilstrup, H., 30 dec. 2011, I: Scandinavian Journal of Clinical & Laboratory Investigation. 71, 2, s. 150-156 7 s.

Effect of Insulin Infusion on Liver Protein Synthesis during Hemodialysis

Reinhard, M., Frystyk, J., Jespersen, B. & Ivarsen, P., 10 nov. 2011. 1 s.

Serum adiponectin concentration is a positive predictor of all-cause and cardiovascular mortality in type 1 diabetes

Forsblom, C., Thomas, M. C., Moran, J., Saraheimo, M., Thorn, L., Wadén, J., Gordin, D., Frystyk, J., Flyvbjerg, A., Groop, P-H. & FinnDiane Study Group, 1 okt. 2011, I: Journal of Internal Medicine. 270, 4, s. 346-55 10 s.

Counter-regulatory hormone responses to spontaneous hypoglycaemia during treatment with insulin Aspart or human soluble insulin. A double-blinded randomised cross-over study

Brock-Jacobsen, I., Vind, B. F., Korsholm, L., Flyvbjerg, A., Frystyk, J., Holst, J. J., Beck-Nielsen, H. & Henriksen, J. E., 11 apr. 2011, I: Acta Physiologica (Print). 202, 3, s. 337-47 1 s.

Markers of inflammation in relation to long-term cardiovascular mortality in patients with lower-extremity peripheral arterial disease

Urbonaviciene, G., Frystyk, J., Flyvbjerg, A., Urbonavicius, S., Henneberg, E. W. & Lindholt, J. S., 2 apr. 2011, I: International Journal of Cardiology. 160, 2, s. 89-94 6 s.

Lack of Dietary Carbohydrates Induces Hepatic Growth Hormone (GH) Resistance in Rats

Bielohuby, M., Sawitzky, M., Stoehr, B. J. M., Stock, P., Menhofer, D., Ebensing, S., Bjerre, M., Frystyk, J., Binder, G., Strasburger, C., Wu, Z., Christ, B., Hoeflich, A. & Bidlingmaier, M., 22 mar. 2011, I: Endocrinology. 152, 5, s. 1948-60 13 s.

Consensus Statement on the Standardization and Evaluation of Growth Hormone and Insulinlike Growth Factor Assays

Clemmons, D. R., Christiansen, J. S. & Frystyk, J., 2 feb. 2011, I: European Journal of Endocrinology. 57, 4, s. 555-9 5 s.

Lack of circulating bioactive and immunoreactive IGF-I changes despite improved fitness in chronic kidney disease patients following 48weeks of physical training

Gregory, S. M., Headley, S. A., Germain, M., Flyvbjerg, A., Frystyk, J., Coughlin, M. A., Milch, C. M., Sullivan, S. & Nindl, B. C., 1 feb. 2011, I: Growth Hormone & IGF Research. 21, 1, s. 51-6 6 s.

Adiponectin in chronic heart failure: influence of diabetes and genetic variants

Masson, S., Gori, F., Latini, R., Milani, V., Flyvbjerg, A., Frystyk, J., Crociati, L., Pietri, S., Vago, T., Barlera, S., Maggioni, A. P., Tognoni, G., Tavazzi, L., Omland, T., Franzosi, M. G. & GISSI-HF Investigators, 2011, I: European Journal of Clinical Investigation. 41, 12, s. 1330-8 9 s.

Adiponectin isoforms, insulin resistance and liver histology in nonalcoholic fatty liver disease

Bianchi, G., Bugianesi, E., Frystyk, J., Tarnow, L., Flyvbjerg, A. & Marchesini, G., 2011, I: Digestive and Liver Disease. 43, 1, s. 73-7 5 s.

Association of plasma osteoprotegerin and adiponectin with arterial function, cardiac function and metabolism in asymptomatic type 2 diabetic men

Chen, W. J. Y., Rijzewijk, L. J., van der Meer, R. W., Heymans, M. W., van Duinkerken, E., Lubberink, M., Lammertsma, A. A., Lamb, H. J., de Roos, A., Romijn, J. A., Smit, J. W. A., Bax, J. J., Bjerre, M., Frystyk, J., Flyvbjerg, A. & Diamant, M., 2011, I: Cardiovascular Diabetology. 10, s. 67

Bioactive IGF-I and IGFBP-1 in Danish children and adolescents 3-5 years after onset of type 1 diabetes. Effect of residual β-cell function

Sørensen, J. S., Frystyk, J., Bjerre, M., Kristensen, K., Pociot, F., Kaad, P. H. & Birkebæk, N. H., 2011, I: Hormone Research in Paediatrics. 76(Suppl. 2), 68

Comparison of plasma metanephrines measured by a commercial immunoassay and urinary catecholamines in the diagnosis of pheochromocytoma

Christensen, T. T., Frystyk, J. & Poulsen, P. L., 2011, I: Scandinavian Journal of Clinical & Laboratory Investigation. 71, 8, s. 695-700 6 s.

Effects of ischemic pre- and postconditioning on HIF-1α, VEGF and TGF-β expression after warm ischemia and reperfusion in the rat liver

Knudsen, A. R., Kannerup, A-S., Grønbæk, H., Andersen, K. J., Funch-Jensen, P., Frystyk, J., Flyvbjerg, A. & Mortensen, F. V., 2011, I: Comparative Hepatology. 10, 1, s. 3

Growth hormone treatment for two years is safe and effective in adults with Prader-Willi syndrome

Sode-Carlsen, R., Farholt, S., Rabben, K. F., Bollerslev, J., Schreiner, T., Jurik, A. G., Frystyk, J., Christiansen, J. S. & Höybye, C., 2011, I: Growth Hormone & IGF Research. 21, 4, s. 185-90 6 s.

Growth hormone treatment, final height, insulin-like growth factors, ghrelin, and adiponectin in four siblings with Seckel syndrome

Birkebaek, N. H., Wolthers, O. D., Heuch, C., Balslev, T., Flyvbjerg, A. & Frystyk, J., 2011, I: Journal of Pediatric Endocrinology and Metabolism. 24, 11-12, s. 995-1000 6 s.

Insulin-like growth factor I - a novel biomarker of abdominal aortic aneurysms

Lindholt, J. S., Martin-Ventura, J. L., Urbonavicius, S., Ramos-Mozo, P., Flyvbjerg, A., Egido, J., Henneberg, E. W. & Frystyk, J., 2011, I: European Journal of Vascular and Endovascular Surgery. 42, 5, s. 560-2 3 s.

Interaction between leptin and leisure-time physical activity and development of hypertension

Asferg, C. L., Møgelvang, R., Flyvbjerg, A., Frystyk, J., Jensen, J., Marott, J. L., Appleyard, M., Schnohr, P., Jensen, G. B. & Jeppesen, J. R., 2011, I: Blood Pressure. 20, 6, s. 362-9 8 s.

Normalisation of insulin-like growth factor-I does not improve insulin action in cirrhosis

Nielsen, M. F., Aagaard, N. K., Grøfte, T., Frystyk, J., Greisen, J., Christiansen, J. S., Holland-Fischer, P. & Vilstrup, H., 2011, I: Liver International. 31, 10, s. 1511-8 8 s.

Serum IGF-I is not a reliable pharmacodynamic marker of exogenous growth hormone activity in mice

Bielohuby, M., Schaab, M., Kummann, M., Sawitzky, M., Gebhardt, R., Binder, G., Frystyk, J., Bjerre, M., Hoeflich, A., Kratzsch, J. & Bidlingmaier, M., 2011, I: Contemporary Endocrinology. 152, 12, s. 4764-76 13 s.

The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women

Harvie, M. N., Pegington, M., Mattson, M. P., Frystyk, J., Dillon, B., Evans, G., Cuzick, J., Jebb, S. A., Martin, B., Cutler, R. G., Son, T. G., Maudsley, S., Carlson, O. D., Egan, J. M., Flyvbjerg, A. & Howell, A., 2011, I: International Journal of Obesity. 35, 5, s. 714-27 14 s.

Unbound (bioavailable) IGF1 enhances somatic growth

Elis, S., Wu, Y., Courtland, H-W., Cannata, D., Sun, H., Beth-On, M., Liu, C., Jasper, H., Domené, H., Karabatas, L., Guida, C., Basta-Pljakic, J., Cardoso, L., Rosen, C. J., Frystyk, J. & Yakar, S., 2011, I: Disease Models and Mechanisms. 4, 5, s. 649-58 10 s.

Whey and casein labeled with L-[1-13C]leucine and muscle protein synthesis: Effect of resistance exercise and protein ingestion

Reitelseder, S., Agergaard, J., Døssing, S., Helmark, I. C., Lund, P., Kristensen, N. B., Frystyk, J. F., Flyvbjerg, A., Schjerling, P., van Hall, G., Kjaer, M. & Holm, L., 2011, I: American Journal of Physiology: Endocrinology and Metabolism. 300, 1, s. E231-42 12 s.

Interferon-β treatment associated with a biochemical profile suggestive of acromegaly. A case report of a patient treated for multiple sclerosis

Andreassen, M., Frystyk, J., Miller, K. K. & Kristensen, L., 1 nov. 2010, I: Scandinavian Journal of Clinical & Laboratory Investigation. 70, 7, s. 519-22 4 s.

Soluble membrane attack complex in ascites in patients with liver cirrhosis without infections

Bjerre, M., Holland-Fischer, P., Grønbæk, H., Frystyk, J., Hansen, T. K., Vilstrup, H. & Flyvbjerg, A., 27 jun. 2010, I: World Journal of Hepatology. 2, 6, s. 221-5 5 s.

Adiponectin and Peak Bone Mass in Men: A Cross-Sectional, Population-Based Study

Munk Frost Nielsen, M., Nielsen, T. L., Frystyk, J., Flyvbjerg, A., Hagen, C., Andersen, M. & Brixen, K., 2010, I: Calcified Tissue International. 87, 1, s. 36-43 8 s.

Adiponectin levels in women with polycystic ovary syndrome: impact of metformin treatment in a randomized controlled study

Trolle, B., Frystyk, J., Flyvbjerg, A. & Lauszus, F., 2010, I: Fertility and Sterility.

Alterations in circulating adiponectin levels occur rapidly after parturition

Fuglsang, J., Sandager, P., Frystyk, J., Møller, N., Flyvbjerg, A. & Ovesen, P., 2010, I: European Journal of Endocrinology. 163, 1, s. 69-73 5 s.

Ascites from patients with alcoholic liver cirrhosis contains higher IGF-I bioactivity than serum

Jeyaratnaganthan, N., Grønbæk, H., Holland-Fischer, P., Espelund, U., Chen, J-W., Flyvbjerg, A., Vilstrup, H. & Frystyk, J., 2010, I: Clinical Endocrinology. 72, 5, s. 625-32 8 s.

Association of serum adiponectin with risk for cardiovascular events in patients with peripheral arterial disease

Urbonaviciene, G., Frystyk, J., Flyvbjerg, A., Henneberg, E. W. & Lindholt, J. S., 2010, I: Atherosclerosis. 210, 2, s. 619-624 6 s.

Brief, high intensity exercise alters serum ghrelin and growth hormone concentrations but not IGF-I, IGF-II or IGF-I bioactivity

Stokes, K. A., Sykes, D., Gilbert, K. L., Chen, J-W. & Frystyk, J., 2010, I: Growth Hormone & IGF Research. 20, 4, s. 289-94 6 s.

Circulating bioactive and immunoreactive IGF-I remain stable in women, despite physical fitness improvements after 8 weeks of resistance, aerobic, and combined exercise training

Nindl, B. C., Alemany, J. A., Tuckow, A. P., Rarick, K. R., Staab, J. S., Kraemer, W. J., Maresh, C. M., Spiering, B. A., Hatfield, D., Flyvbjerg, A. & Frystyk, J., 2010, I: Journal of Applied Physiology. 109, 1, s. 112-20 9 s.

Circulating levels of insulin-like growth factor-II/mannose-6-phosphate receptor in obesity and type 2 diabetes

Jeyaratnaganthan, N., Højlund, K., Kroustrup, J. P., Larsen, J. F., Bjerre, M., Levin, K., Beck-Nielsen, H., Frago, S., Hassan, A. B., Flyvbjerg, A., Frystyk, J. & Larsen, J. F., 2010, I: Growth Hormone & IGF Research. 20, 3, s. 185-191 7 s.

Conventional and Novel Biomarkers of Treatment Outcome in Patients with Acromegaly: Discordant Results after Somatostatin Analogue Treatment as Compared to Surgery

Rubeck, K. Z., Madsen, M., Andreasen, C. M., Fisker, S., Frystyk, J. & Jørgensen, J. O. L., 2010, I: European Journal of Endocrinology. 163, 5, s. 717-726 9 s.

Effect of sex hormone treatment on circulating adiponectin and subforms in Turner and Klinefelter syndrome

Høst, C., Bojesen, A., Frystyk, J., Flyvbjerg, A., Christiansen, J. S. & Gravholt, C. H., 2010, I: European Journal of Clinical Investigation. 40, 3, s. 211-219 9 s.

Effects of ischemic pre- and postconditioning on HIF-1α, VEGF and TGF-β expression during warm liver ischemia and reperfusion.

Knudsen, A. R., Kannerup, A-S., Grønbæk, H., Funch-Jensen, P., Frystyk, J., Flyvbjerg, A. & Mortensen, F. V., 2010.

Effects of oral contraceptives on diurnal profiles of insulin, insulin-like growth factor binding protein-1, growth hormone and cortisol in endurance athletes with menstrual disturbance

Rickenlund, A., Thorén, M., Nybacka, A., Frystyk, J. & Lindén Hirschberg, A., 2010, I: Human Reproduction. 25, 1, s. 85-93 9 s.

Exercise and the growth hormone-insulin-like growth factor axis

Frystyk, J., 2010, I: Medicine and Science in Sports and Exercise. 42, 1, s. 58-66 8 s.

Interferon-β treatment associated with a biochemical profile suggestive of acromegaly. A case report of a patient treated for multiple sclerosis

Andreassen, M., Frystyk, J., Miller, K. K. & Kristensen, L. Ø., 2010, I: Scandinavian Journal of Clinical & Laboratory Investigation. 70, 7, s. 519-22 4 s.

Leptin, Not Adiponectin, Predicts Hypertension in the Copenhagen City Heart Study

Asferg, C., Møgelvang, R., Flyvbjerg, A., Frystyk, J., Jensen, J. S., Marott, J. L., Appleyard, M., Jensen, G. B. & Jeppesen, J., 2010, I: American Journal of Hypertension. 23, 3, s. 327-333 7 s.

Marked reductions in bioactive insulin-like growth factor I (IGF-I) during hemodialysis

Ivarsen, P., Chen, J-W., Tietze, I., Christiansen, J. S., Flyvbjerg, A. & Frystyk, J., 2010, I: Growth Hormone & IGF Research. 20, 2, s. 156-61 6 s.

Moderate energy restriction induced weight loss affects circulating IGF levels independent of dietary composition

Belobrajdic, D., Frystyk, J., Jeyaratnaganthan, N., Espelund, U., Flyvbjerg, A., Clifton, P. & Noakes, M., 2010, I: European Journal of Endocrinology. 162, 6, s. 1075-1082 8 s.

Serum adiponectin is associated with homocysteine in elderly men and women, and with 5,10-methylenetetrahydrofolate reductase (MTHFR) in a sex-dependent manner

Dankner, R., Chetrit, A., Murad, H., Sela, B-A., Frystyk, J., Raz, I. & Flyvbjerg, A., 2010, I: Metabolism. 59, 12, s. 1767 - 74 8 s.

The current status of IGF-I assays - A 2009 update

Frystyk, J., Freda, P. & Clemmons, D. R., 2010, I: Growth Hormone & IGF Research. 20, 1, s. 8-18 11 s.

Total adiponectin does not predict cardiovascular events in middle-aged men in a prospective, long-term follow-up study

Khalili, P., Flyvbjerg, A., Frystyk, J., Lundin, F., Jendle, J., Engström, G. & Nilsson, P. M., 2010, I: Diabetes & Metabolism. 36, 2, s. 137-143 7 s.

Tumor necrosis factor-alpha acutely up-regulates urea synthesis in vivo in rats - a hepatic component of inflammatory catabolism?

Thomsen, K. L., Nielsen, S. S., Aagaard, N. K., Sandahl, T. D., Grønbæk, H., Frystyk, J., Flyvbjerg, A. & Vilstrup, H., 2010, I: Scandinavian Journal of Clinical and Laboratory Investigation. Supplement. 70, 3, s. 151-7 7 s.

Unchanged capacity of urea synthesis during acute phase response in rats

Thomsen, K. L., Aagaard, N. K., Nielsen, S. S., Grønbæk, H., Jessen, N., Frystyk, J. & Vilstrup, H., 2010, I: European Journal of Clinical Investigation. 41, 1, s. 16-22 7 s.

A randomized placebo-controlled study on the effects of pioglitazone on cortisol metabolism in polycystic ovary syndrome

Glintborg, D., Hermann, A. P., Hagen, C., Jensen, L. T., Frystyk, J., Bennett, P., Flyvbjerg, A. & Andersen, M., 2009, I: Fertility and Sterility. 91, 3, s. 842-50 8 s.

Adiponectin and lipoprotein particle size

Weiss, R., Otvos, J. D., Flyvbjerg, A., Miserez, A. R., Frystyk, J., Sinnreich, R. & Kark, J. D., 2009, I: Diabetes Care. 32, 7, s. 1317-1319 3 s.

Adiponectin, retinol binding protein 4 and leptin in protracted critical illness of pulmonary origin

Langouche, L., Vander Perre, S., Frystyk, J., Flyvbjerg, A., Krarup Hansen, T. & Van den Berghe, G., 2009, I: Critical Care. 13, 4, s. R112-R118 6 s.

Associations of serum adiponectin with skeletal muscle morphology and insulin sensitivity

Ingelsson, E., Arnlöv, J., Zethelius, B., Vasan, R. S., Flyvbjerg, A., Frystyk, J., Berne, C., Hänni, A., Lind, L. & Sundström, J., 2009, I: Journal of Clinical Endocrinology and Metabolism. 94, 3, s. 953-7 4 s.

Bioactive IGF-I in Obesity

Frystyk, J., Brick, D. J., Gerweck, A. V., Utz, A. L. & Miller, K. K., 2009, I: Journal of Clinical Endocrinology and Metabolism. 94, 8, s. 3093-7 5 s.

Diet, body composition, and physical fitness influences on IGF-I bioactivity in women

Philip Karl, J., Alemany, J. A., Koenig, C., Kraemer, W. J., Frystyk, J., Flyvbjerg, A., Young, A. J. & Nindl, B. C., 2009, I: Growth Hormone & IGF Research. 19, 6, s. 491-96 6 s.

Effect of administration of oral contraceptives in vivo on collagen synthesis in tendon and muscle connective tissue in young women

Hansen, M., Miller, B. F., Holm, L., Døssing, S., Petersen, S. G., Skovgaard, D., Frystyk, J., Flyvbjerg, A., Koskinen, S., Pingel, J., Kjaer, M. & Langberg, H., 2009, I: Journal of Applied Physiology. 106, 4, s. 1435-43 8 s.

Effect of estrogen on tendon collagen synthesis, tendon structural characteristics, and biomechanical properties in postmenopausal women

Hansen, M., Kongsgaard, M., Holm, L., Skovgaard, D., Magnusson, S. P., Qvortrup, K., Larsen, J. O., Aagaard, P., Dahl, M., Serup, A., Frystyk, J., Flyvbjerg, A., Langberg, H. & Kjær, M., 2009, I: Journal of Applied Physiology. 106, 4, s. 1385-93 8 s.

High-molecular weight adiponectin is associated with coronary artery angiographic findings in Asian Indians

Zornitzki, T., Reshef, N., Ayzenberg, O., Cohen, R., Gandelman, G., Frystyk, J. J., Flyvbjerg, A. & Knobler, H., 2009, I: Metabolism. 58, 5, s. 632-7 5 s.

Impact of fasting on growth hormone signaling and action in muscle and fat

Møller, L., Dalman, L., Nørrelund, H., Billestrup, N., Frystyk, J., Møller, N. & Jørgensen, J. O. L., 2009, I: Journal of Clinical Endocrinology and Metabolism. 94, 3, s. 965-72 8 s.

Lack of effect of IGF-I on the glomerular filtration rate in non-diabetic patients with advanced chronic kidney disease

Kuan, Y., Surman, J., Frystyk, J., El Nahas, A. M., Flyvbjerg, A. & Haylor, J. L., 2009, I: Growth Hormone & IGF Research. 19, 3, s. 219-25 6 s.

Leptin, ghrelin, and endocannabinoids: potential therapeutic targets in anorexia nervosa

Støving, R. K., Andries, A., Brixen, K., Flyvbjerg, A., Hørder, K. & Frystyk, J., 2009, I: Journal of Psychiatric Research. 43, 7, s. 671-9 8 s.

Lycopene supplementation (passata sauce) reduces apoptosis but does not affect oxidant-responsive heme oxygenase-1 in human lymphocytes

Markovitch, D., Tyrrell, R. M., Tauler, P., Frystyk, J., Stokes, K. & Thompson, D., 2009, I: Nutrition. 25, 6, s. 668-75 7 s.

Peroxisome proliferator-activated receptor gamma (PPAR) agonism reduces the insulin-stimulated increase in circulating interleukin-6 in GH replaced GH-deficient adults

Krag, M. B., Rasmussen, L. M., Hansen, T. K., Frystyk, J., Flyvbjerg, A., Møller, N. & Jørgensen, J. O. L., 2009, I: Clinical Endocrinology. 71, 3, s. 363-8 5 s.

Pituitary-independent effect of octreotide on IGF1 generation

Pokrajac, A., Frystyk, J., Flyvbjerg, A. & Trainer, P. J., 2009, I: European Journal of Endocrinology. 160, 4, s. 543-8 5 s.

Plasma Adiponectin in Patients with Active, Early, and Chronic Rheumatoid Arthritis Who Are Steroid- and Disease -Modifying Antirheumatic Drug-Naive Compared with Patients with Osteoarthritis and Controls

Laurberg, T. B., Frystyk, J., Ellingsen, T., Hansen, I. T., Jørgensen, A., Tarp, U., Hetland, M. L., Hørslev-Petersen, K., Hornung, N., Poulsen, J. H., Flyvbjerg, A. & Stengaard-Pedersen, K., 2009, I: Journal of Rheumatology. 36, 9, s. 1885-91 7 s.

Relationship of adiposity with arterial stiffness as mediated by adiponectin in older men and women: the Hoorn Study

Snijder, M. B., Flyvbjerg, A., Stehouwer, C. D. A., Frystyk, J., Henry, R. M. A., Seidell, J. C., Heine, R. J. & Dekker, J. M., 2009, I: European Journal of Endocrinology. 160, 3, s. 387-95 8 s.

Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism

Yakar, S., Rosen, C. J., Bouxsein, M. L., Sun, H., Mejia, W., Kawashima, Y., Wu, Y., Emerton, K., Williams, V., Jepsen, K., Schaffler, M. B., Majeska, R. J., Gavrilova, O., Gutierrez, M., Hwang, D., Pennisi, P., Frystyk, J., Boisclair, Y., Pintar, J., Jasper, H., Domene, H., Cohen, P., Clemmons, D. & LeRoith, D., 2009, I: F A S E B Journal. 23, 3, s. 709-19 10 s.

Subcutaneous Rather than Visceral Adipose Tissue Is Associated with Adiponectin Levels and Insulin Resistance in Young Men

Frederiksen, L., Nielsen, T. L., Wraae, K., Hagen, C., Frystyk, J., Flyvbjerg, A., Brixen, K. & Andersen, M., 2009, I: Journal of Clinical Endocrinology and Metabolism. 94, 10, s. 4010-5 6 s.

The IGF system after insertion of a transjugular intrahepatic porto-systemic shunt in patients with liver cirrhosis

Holland-Fischer, P., Vilstrup, H., Frystyk, J., Nielsen, D. T., Flyvbjerg, A. & Grønbaek, H., 2009, I: European Journal of Endocrinology. 160, 6, s. 957-63 6 s.

The Role of Insulin-Like Growth Factor (IGF) Binding Protein-2 in the Insulin-Mediated Decrease in IGF-I Bioactivity

Arafat, A. M., Weickert, M. O., Frystyk, J., Spranger, J., Schöfl, C., Möhlig, M. & Pfeiffer, A. F. H., 2009, I: Journal of Clinical Endocrinology and Metabolism. 94, 12, s. 5093-5101 9 s.

Adiponectin and left ventricular structure and function in healthy adults

Kozakova, M., Muscelli, E., Flyvbjerg, A., Frystyk, J., Morizzo, C., Palombo, C. & Ferrannini, E., 2008, I: Journal of Clinical Endocrinology and Metabolism. 93, 7, s. 2811-8 7 s.

Comparison of Pancreas-Transplanted Type 1 Diabetic Patients with Portal-Venous Versus Systemic-Venous Graft Drainage: Impact on Glucose Regulatory Hormones and the Growth Hormone/Insulin-Like Growth Factor-I Axis

Frystyk, J., Ritzel, R. A., Maubach, J., Büsing, M., Lück, R., Klempnauer, J., Schmiegel, W. & Nauck, M. A., 2008, I: Journal of Clinical Endocrinology and Metabolism. 93, 5, s. 1758-1766 8 s.

Determination of free growth hormone

Frystyk, J., Andreasen, C. M. & Fisker, S., 2008, I: Journal of Clinical Endocrinology and Metabolism. 93, 8, s. 3008-14 6 s.

Elevated free IGF2 levels in localized, early-stage breast cancer in women

Espelund, U., Cold, S., Frystyk, J., Ørskov, H. & Flyvbjerg, A., 2008, I: European Journal of Endocrinology. 159, 5, s. 595-601 6 s.

Elevated levels of high-molecular-weight adiponectin in type 1 diabetes

Leth, H., Andersen, K. K., Frystyk, J., Tarnow, L., Rossing, P., Parving, H-H. & Flyvbjerg, A., 2008, I: Journal of Clinical Endocrinology and Metabolism. 93, 8, s. 3186-91 5 s.

Ethinyl oestradiol administration in women suppresses synthesis of collagen in tendon in response to exercise

Hansen, M., Koskinen, S. O., Petersen, S. G., Doessing, S., Frystyk, J., Flyvbjerg, A., Westh, E., Magnusson, S. P., Kjaer, M. & Langberg, H., 2008, I: Journal of Physiology. 586, Pt 12, s. 3005-16 11 s.

Fetal growth velocity, size in early life and adolescence, and prediction of bone mass: association to the GH-IGF axis

Jensen, R. B., Vielwerth, S., Frystyk, J., Veldhuis, J., Larsen, T., Mølgaard, C., Greisen, G. & Juul, A., 2008, I: Journal of Bone and Mineral Research. 23, 3, s. 439-46 7 s.

Increased levels of alpha-defensin (-1, -2 and -3) in type 1 diabetic patients with nephropathy

Saraheimo, M., Forsblom, C., Petterson-Fernholm, K., Flyvbjerg, A., Groop, P. H., Frystyk, J. & FinnDiane Study Group, 2008, I: Nephrology, Dialysis, Transplantation. 23, 3, s. 914-918 5 s.

Increased protein turnover and proteolysis is an early and primary feature of short-term experimental hyperthyroidism in healthy women

Riis, A. L. D., Jørgensen, J. O. L., Ivarsen, P., Frystyk, J., Weeke, J. & Møller, N., 2008, I: Journal of Clinical Endocrinology and Metabolism. 93, 10, s. 3999-4005 6 s.

Low circulating insulin-like growth factor I bioactivity in elderly men is associated with increased mortality.

Brugts, MP., Van den Beld, AW., Hofland, LJ., Van der Hassum, K., Van Koetsveld PM, Frystyk, J., Lamberts, SWJ. & Janssen, JAMLJ., 2008, I: Journal of Clinical Endocrinology and Metabolism. 93, s. 2515-2522

Normal values of circulating insulin-like growth factor-I bioactivity in the healthy population: comparison with five widely used IGF-I immunoassays

Brugts, M. P., Ranke, M. B., Hofland, L. J., van der Wansem, K., Weber, K., Frystyk, J., Lamberts, S. W. J. & Janssen, J. A. M. J. L., 2008, I: Journal of Clinical Endocrinology and Metabolism. 93, 7, s. 2539-45 6 s.

Plasma alpha-defensin is associated with cardiovascular morbidity and mortality in type 1 diabetic patients

Joseph, G., Tarnow, L., Astrup, A. S., Hansen, T. K., Parving, H-H., Flyvbjerg, A. & Frystyk, J., 2008, I: Journal of Clinical Endocrinology and Metabolism. 93, 4, s. 1470-5 5 s.

Serum adiponectin and progression of diabetic nephropathy in patients with type 1 diabetes

Saraheimo, M., Forsblom, C., Thorn, L., Wadén, J., Rosengård-Bärlund, M., Heikkilä, O., Hietala, K., Gordin, D., Frystyk, J., Flyvbjerg, A., Groop, P-H. & FinnDiane Study Group, 2008, I: Diabetes Care. 31, 6, s. 1165-9 4 s.

Serum adiponectin in elderly men does not correlate with fracture risk

Michaëlsson, K., Lind, L., Frystyk, J., Flyvbjerg, A., Gedeborg, R., Berne, C., Zethelius, B., Mallmin, H., Söderberg, S. & Melhus, H., 2008, I: Journal of Clinical Endocrinology and Metabolism. 93, 10, s. 4041-7 6 s.

Serum adiponectin predicts all-cause mortality and end stage renal disease in patients with type I diabetes and diabetic nephropathy

Jorsal, A., Tarnow, L., Frystyk, J., Lajer, M., Flyvbjerg, A., Parving, H-H., Vionnet, N. & Rossing, P., 2008, I: Kidney International. 74, 5, s. 649-54 5 s.

The development of microalbuminuria is associated with raised longitudinal adiponectin levels in female but not male adolescent patients with type 1 diabetes

Amin, R., Frystyk, J., Ong, K., Dalton, R. N., Flyvbjerg, A. & Dunger, D. B., 2008, I: Diabetologia. 51, 9, s. 1707-13 6 s.

The effect of weight loss after gastric banding on the molecular distribution of serum adiponectin

Leth, H., Kroustrup, J. P., Larsen, J. F., Andersen, K. K., Flyvbjerg, A. & Frystyk, J., 2008, I: European Journal of Endocrinology. 159, 3, s. 357

Total and high molecular weight (HMW) adiponectin levels and measures of glucose and lipid metabolism following pioglitazone treatment in a randomized placebo-controlled study in polycystic ovary syndrome

Glintborg, D., Frystyk, J., Højlund, K., Andersen, K. J., Henriksen, J. E., Hermann, A. P., Hagen, C., Flyvbjerg, A. & Andersen, M., 2008, I: Clinical Endocrinology. 68, s. 165-174 10 s.

Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects

Patel, S., Flyvbjerg, A., Kozàkovà, M., Frystyk, J., Ibrahim, M., Petrie, J. R., Avery, P. J., Ferrannini, E., Walker, M. & RISC Investigators, 2008, I: European Heart Journal. 29, 3, s. 386-393 8 s.

The insulin-like growth factor (IGF) system and its relation to infliximab treatment in adult patients with Crohn's disease

Eivindson, M., Grønbaek, H., Skogstrand, K., Thorsen, P., Frystyk, J., Flyvbjerg, A. & Dahlerup, J. F., apr. 2007, I: Scandinavian Journal of Gastroenterology. 42, 4, s. 464-70 7 s.

Assessing the potential usefulness of IGF-related peptides and adiponectin for predicting disease risk

Belobrajdic, D. P., Priebe, I. K., Forbes, B., Flyvbjerg, A., Chen, J-W., Cosgrove, L. J., Frystyk, J. & Saunders, I. W., 2007, I: Growth Hormone & IGF Research. 18, 3, s. 198-204 6 s.

Bioactive IGF-I and IGF-binding protein-1 in anorexia nervosa

Støving, R. K., Chen, J-W., Glintborg, D., Brixen, K., Flyvbjerg, A., Hørder, K. & Frystyk, J., 2007, I: Journal of Clinical Endocrinology and Metabolism. 92, 6, s. 2323-2329 7 s.

Concomitant, specific determination of growth hormone and pegvisomant in human serum

Ørskov, H., Frystyk, J., Nielsen, C., Hansen, A. T., Weeke, J. & Jørgensen, J. O. L., 2007, I: Growth. Horm. IGF. Res.. 17, 5, s. 431-434 4 s.

Early elective insulin therapy prevents hyperglycaemia and increases IGF-1 levels in very low birth weight infants

Beardsall, K., Ong, K. K., Frystyk, J., Chen, J. W., Ogilvy-Stuart, A. L., Ahluwalia, J., Thomson, M. & Dunger, D. B., 2007, I: J Pediatr. 151, 6, s. 611-617 7 s.

Fetal Growth Velocity, Size in Early Life and Adolescence and Prediction of Bone Mass: Association to the GH-IGF Axis

Jensen, R. B., Vielwerth, S., Frystyk, J., Veldhuis, J., Larsen, T., Mølgaard, C., Greisen, G. & Juul, A., 2007, I: J. Bone Miner. Res.. s. Epub ahead of print 27 s.

Gender differences of oligomers and total adiponectin during puberty: a cross-sectional study of 859 Danish school children.

Andersen, K. K., Frystyk, J., Wolthers, O. D., Heuck, C. & Flyvbjerg, A., 2007, I: Journal of Clinical Endocrinology and Metabolism. 92, 5, s. 1857-62 5 s.

Hypoglycemia due to paraplastic secretion of insulin-like growth factor Iin a patient with metastasizing large-cell carcinoma of the lung

Nauck, M. A., Reinecke, M., Perren, A., Frystyk, J., Berishvili, G., Zwimpfer, C., Figge, A., Flyvbjerg, A., Lankisch, P. G., Blum, W., Kloppel, G., Schmiegel, W. & Zapf, J., 2007, I: Journal of Clinical Endocrinology and Metabolism. 92, 5, s. 1600-1605 6 s.

Medicinsk kombinationsbehandling af akromegali med somatostatinanalog og en væksthormon-receptorantagonist

Jørgensen, J. O. L., Feldt-Rasmussen, U., Frystyk, J., Chen, J-W., Kristensen, L. Ø., Hagen, C. & Ørskov, H., 2007, I: Ugeskrift for Laeger. 169, 10, s. 911-913 3 s.

Normal growth spurt and final height despite low levels of all forms of circulating IGF-I in a patient with ALS deficiency

Domené, H., Martinez, A. S., Frystyk, J., Bengolea, S. V., Ropelato, M. G., Scaglia, P., Chen, J. W., Heuck, C., Wolthers, O. D., Heinrich, J. J. & Jasper, H. G., 2007, I: Hormone Research. 67, 5, s. 243-249 7 s.

Normal growth spurt and final height despite low levels of all forms of circulating insulin-like growth factor-I in a patient with acid-labile subunit deficiency.

Domené, H. M., Martínez, A. S., Frystyk, J., Bengolea, S. V., Ropelato, M. G., Scaglia, P. A., Chen, J-W., Heuck, C., Wolthers, O. D., Heinrich, J. J. & Jasper, H. G., 2007, I: Hormone Research. 67, 5, s. 243-9 6 s.

Phenotypic Effects of Null and Haploinsufficiency of Acid-Labile Subunit in a family with Two Novel IGFALS Gene Mutations

Domené, H. M., Scaglia, P. A., Lteif, A., Mahmud, F. H., Kirmani, S., Frystyk, J., Bedecarrás, P., Gutiérrez, M. & Jasper, H. G., 2007, I: Journal of Clinical Endocrinology and Metabolism. 92, 11, s. 4444-4450 7 s.

Serum adiponectin is a predictor of coronary heart disease: a population-based 10-year follow-up study in elderly men

Frystyk, J., Berne, C., Berglund, L. E., Jensevik, K., Flyvbjerg, A. & Zethelius, B., 2007, I: Journal of Clinical Endocrinology and Metabolism. 92, 2, s. 571-576 6 s.

The effects of sex steroid replacement therapy on an expanded panel of IGF-related peptides.

Renehan, A. G., Frystyk, J., Howell, A., Dwyer, S. T., Shalet, S. M. & Flyvbjerg, A., 2007, I: Growth. Horm. IGF. Res.. 17, 3, s. 210-219 10 s.

The insulin-like growth factor (IGF) system and its relation to infliximab treatment in adult patients with Crohn's disease

Eivindson, M., Grønbæk, H., Skogstrand, K., Thorsen, P., Frystyk, J., Flyvbjerg, A. & Dahlerup, J. F., 2007, I: Scandinavian Journal of Gastroenterology. 42, 4, s. 464-470 7 s.

The insulin-like growth factor (IGF)-system in active ulcerative colitis and Crohn's disease: relations to disease activity and corticosteroid treatment

Eivindson, M., Grønbaek, H., Flyvbjerg, A., Frystyk, J., Zimmermann-Nielsen, E. & Dahlerup, J. F., 2007, I: Growth Hormone & IGF Research. 17, 1, s. 33-40 7 s.

Utility of free igf-I measurements

Frystyk, J., 2007, I: Pituitary. 10, 2, s. 181-187 7 s.

A longitudinal study of serum adiponectin during normal pregnancy

Fuglsang, J., Skjaerbaek, C., Frystyk, J., Flyvbjerg, A. & Ovesen, P., 2006, I: B J O G. 113, 1, s. 110-3 3 s.

Abnormalities of whole body protein turnover, muscle metabolism and levels of metabolic hormones in patients with chronic heart failure

Nørrelund, H., Wiggers, H., Halbirk, M., Frystyk, J., Flyvbjerg, A., Bøtker, H. E., Schmitz, O., Jørgensen, J. O. L., Christiansen, J. S. & Møller, N., 2006, I: J. Intern. Med.. 260(1), s. 11-21 11 s.

Adiponectin and risk of congestive heart failure

Ingelsson, E., Risérus, U., Berne, C., Frystyk, J., Flyvbjerg, A. & Zethelius, B., 2006, I: JAMA: The Journal of the American Medical Association. 295, 15, s. 1772-1774 3 s.

Body composition is distinctly altered in Turner syndrome: relations to glucose metabolism, circulating adipokines, and endothelial adhesion molecules

Gravholt, C. H., Hjerrild, B. E., Mosekilde, L., Hansen, T. K., Rasmussen, L. M., Frystyk, J., Flyvbjerg, A. & Christiansen, J. S., 2006, I: European Journal of Endocrinology. 155, 4, s. 583-592 10 s.

Changes in bioactive IGF-I and IGF-binding protein-1 during an oral glucose tolerance test in patients with liver cirrhosis

Chen, J-W., Nielsen, M. F., Caumo, A., Christiansen, J. S., Vilstrup, H. & Frystyk, J., 2006, I: European Journal of Endocrinology. 155, s. 285-292 8 s.

Diminished Growth and Enhanced Glucose Metabolism in triple knock out mice containing mutations of insulin like-growth factor (IGF) binding proteins -3, -4, and -5

Ning, Y., Schuller, A. G. P., Bradshaw, S., Rotwein, P., Ludwig, T., Frystyk, J. & Pintar, J. E., 2006, I: Mol. Endocrinol.. 20, s. 2173-2186 14 s.

Dynamic changes in serum adiponectin during normal pregnancy

Fuglsang, J., Skjærbæk, C., Frystyk, J., Flyvbjerg, A. & Ovesen, P. G., 2006, I: B J O G. 113, s. 110-113 4 s.

Elevated circulating adiponectin in type 1 diabetes is associated with long diabetes duration

Lindström, T., Frystyk, J., Hedman, C. A., Flyvbjerg, A. & Arnquist, H. J., 2006, I: Clinical Endocrinology. 65, 6, s. 776-782 7 s.

Evaluation of metabolic risk markers in PCOS: Adiponectin, ghrelin, leptin and body composition in hirsute PCOS patients and controls

Glintborg, D., Andersen, M., Hagen, C., Frystyk, J., Hulstrøm, V., Flyvbjerg, A. & Hermann, AP., 2006, I: Eur J Endo. 155, s. 337-345 9 s.

Glycosaminoglycans increase levels of free and bioactive IGF-I in vivo

Møller, A. V., Jørgensen, S. P., Chen, J-W., Larnkjær, A., Ledet, T., Flyvbjerg, A. & Frystyk, J., 2006, I: European Journal of Endocrinology. 155, 2, s. 297-305 9 s.

Hypoadiponectinemia Is Associated with Insulin Resistance and Glucose Intolerance after Renal Transplantation: Impact of Immunosuppressive and Antihypertensive Drug Therapy

Hjelmesæth, J., Flyvbjerg, A., Jenssen, T., Frystyk, J., Ueland, T., Hagen, M. & Hartmann, A., 2006, I: Clin J Am Soc Nephrol. 1, s. 575-582 8 s.

Obesity and cancer risk: The role of the insulin-IGF axis

Renehan, A. G., Frystyk, J. & Flyvbjerg, A., 2006, I: Trends Endocrinol Metab. 17, 8, s. 328-336 9 s.

Peripartum maternal and foetal ghrelin, growth hormones, IGFs and insulin interrelations

Fuglsang, J., Sandager, K. P., Møller, N., Fisker, S., Frystyk, J. & Ovesen, P. G., 2006, I: Clinical Endocrinology. 64, 5, s. 502 - 9 7 s.

Pharmacokinetic studies of rhIGF-I/rhIGFBP-3 complex administered to patients with growth hormone insensitivity syndrome

Camacho-Hübner, C., Rose, S., Preece, M. A., Sleevi, M., Storr, H. L., Miraki-Moud, F., Barreca, A., Minuto, F., Frystyk, J., Rogol, A., Allan, G., Sommer, A. & Savage, M. O., 2006, I: Journal of Clinical Endocrinology and Metabolism. 91, s. 1246-1253 8 s.

Plasma adiponectin levels in relation to carotid intima media thickness and markers of insulin resistance

Nilsson, P. M., Engström, G., Hedblad, B., Frystyk, J., Persson, M. M., Berglund, G. & Flyvbjerg, A., 2006, I: Arteriosclerosis, Thrombosis, and Vascular Biology. 26, 12, s. 2758-2762 5 s.

Reduced plasma adiponectin concentrations may contribute to impaired insulin activation of glycogen synthase in skeletal muscle of patients with type 2 diabetes

Højlund, K., Frystyk, J., Levin, K., Flyvbjerg, A., Wojtaszewski, J. & Beck-Nielsen, H., 2006, I: Diabetologia. 49, s. 1283-1291 9 s.

Serum ghrelin levels are suppressed in hypopituitary patients following insulin-induced hypoglycaemia irrespective of GH status

Ryber, L., Öbrink, K., Houe, N., Frystyk, J. & Jørgensen, J. O. L., 2006, I: Clinical Endocrinology. 65, 2, s. 210-214 5 s.

The GH-IGF-IGFBP axis is changed in Turner syndrome: Partial normalization by HRT

Gravholt, C. H., Chen, J-W., Oxvig, C., Overgaard, M. T., Christiansen, J. S., Frystyk, J. & Flyvbjerg, A., 2006, I: Growth. Horm. IGF. Res.. 16, 5-6, s. 332-9 8 s.

The metabolic syndrome is frequent in Klinefelter's syndrome and is associated with abdominal obesity and hypogonadism.

Bojesen, A. B., Kristensen, K., Birkebæk, N., Fedder, J., Mosekilde, L., Bennet, P., Laurberg, P., Frystyk, J., Flyvbjerg, A., Christiansen, J. S. & Gravholt, C. H., 2006, I: Diabetes Care. 29, 7, s. 1591-8

The metabolic syndrome is frequent in Klinefelter's syndrome and is associated with abdominal obesity and hypogonadism

Bojesen, A., Kristensen, K., Birkebaek, N. H., Fedder, J., Mosekilde, L., Bennett, E. P., Laurberg, P., Frystyk, J., Flyvbjerg, A., Christiansen, J. S. & Gravholt, C. H., 2006, I: Diabetes Care. 29, 7, s. 1591-8 8 s.

Sex-discordant associations with adiponectin levels and lipid profiles in children

Ong, K. K., Frystyk, J., Mericq, V., Flyvbjerg, A., Petry, C. J., Study Team, ALSPAC., Ness, A. & Dunger, D. B., 2006, I: Diabetes. 55, s. 1337-1341 5 s.

Impact of insulin antibodies on insulin aspart pharmacokinetics and pharmacodynamics after 12-week treatment with multiple daily injections of biphasic insulin aspart 30 in patients with type 1 diabetes

Chen, J-W., Frystyk, J., Lauritzen, T. & Christiansen, J. S., 1 dec. 2005, I: European Journal of Endocrinology. 153, 6, s. 907-13 7 s.

ALS inhibits the transport of IGF-I and -II across cultured endothelial cells

Frystyk, J., 2005, I: IGM. 15, s. 23-24 2 s.

Adiponectin is increased in type 1 diabetes with nephropathy

Saraheimo, M., Forsblom, C., Fagerudd, J., Teppo, A-M., Petterson-Fernholm, K., Frystyk, J., Flyvbjerg, A. & Groop, P-H., 2005, I: Diabetes Care. 28, s. 1410-1414 5 s.

Co-treatment of acromegaly with a somatostatin analogue and a growth hormone receptor antagonist

Jørgensen, J. O. L., Rasmussen, U. F., Frystyk, J., Chen, J., Kristensen, L. Ø., Hagen, C. & Ørskov, H. C., 2005, I: Journal of Clinical Endocrinology and Metabolism. 90, s. 5627-5631 5 s.

Effects of pure ethanol and alcopops on glucose, insulin, and the insulin-like growth factor system in healthy subjects.

Grønbæk, H., Flyvbjerg, A., Winding, P., Frystyk, J. & Hey, H., 2005, I: Growth Hormone & IGF Research. 15, s. 243-50

Fasting unmasks a strong inverse association between ghrelin and cortisol in serum: studies in obese and normal-weight subjects

Espelund, U., Hansen, T. K., Højlund, K., Beck-Nielsen, H., Clausen, J. T., Hansen, B. S., Ørskov, H. C., Jørgensen, J. O. L. & Frystyk, J., 2005, I: Journal of Clinical Endocrinology and Metabolism. 90, s. 741-746 6 s.

Free rather than total circulating IGF-I determines the feedback on GH release in normal subjects

Chen, J., Højlund, K., Ledet, T., Christiansen, J. S., Ørskov, H. C. & Frystyk, J., 2005, I: Journal of Clinical Endocrinology and Metabolism. 90, s. 366-371 6 s.

Ghrelin and its relationship to growth hormones during normal pregnancy

Fuglsang, J., Skjaerbaek, C., Espelund, U., Frystyk, J., Fisker, S., Flyvbjerg, A. & Ovesen, P., 2005, I: Clinical Endocrinology. 62, 5, s. 554-9 5 s.

Human growth hormone responses to repeated bouts of sprint exercise with different recovery periods between bouts

Stokes, K., Nevill, M., Frystyk, J., Lakomy, H. & Hall, G., 2005, I: J. Appl. Physiol.. 99, s. 1254-1261 8 s.

IGF-I in synovial fluid and plasma correlate with global assessment, pain on VAS and HAQ in chronic rheumatoid arthritis. [THU0331]

Laurberg, T. B., Ellingsen, T. J., Frystyk, J., Flyvbjerg, A., Buus, A. & Stengaard-Pedersen, K., 2005.

IGF-I replacement therapy increases albumin concentration in liver cirrhosis: results from a randomized controlled clinical trial

Conchillo, M., de Knegt, R., Payeras, M., Quiroga, J., Sangro, B., Herrero, J. I., Castilla-Cortazar, I., Frystyk, J., Flyvbjerg, A., Yoshizawa, C., Jansen, P., Scharschmidt, B. & Prieto, J., 2005, I: J. Hepatol.. 43, s. 630-636 7 s.

Immuno- and bioassayable IGF activity during submaximal exercise in GH-deficient patients and healthy subjects

Kaneley, J. A., Frystyk, J., Møller, N., Dall, R., Wen-Chen, J., Christiansen, J. S., Jørgensen, J. O. L. & Flyvbjerg, A., 2005, I: Growth. Horm. IGF. Res.. 15, s. 283-290 8 s.

Impact of sex steroids on fasting concentrations of free IGF-I, IGFBP-1 and the dimeric IGF-I/IGFBP-1 complex and the initial rates of distribution of infused recombinant human IGF-I in men and women

Veldhuis, J. D., Frystyk, J., Iranmanesh, A. & Ørskov, H. C., 2005, I: Journal of Clinical Endocrinology and Metabolism. 90, s. 2941-2947 7 s.

Improvement in insulin sensitivity without changes in body composition and cardiovascular risk markers following fixed administration of a very low growth hormone (GH) dose in adults with severe GH deficiency

Yuen, K., Frystyk, J., White, D. K., Twickler, T. B., Koppeschaar, H. P., Harris, P. E., Fryklund, L., Murgatroyd, P. R. & Dunger, D. B., 2005, I: Clinical Endocrinology. 63, s. 428-436 9 s.

Increased serum adiponectin levels in type 1 diabetic patients with microvascular complications

Frystyk, J., Tarnow, L., Hansen, T. K., Parving, H-H. & Flyvbjerg, A., 2005, I: Diabetologia. 48, s. 1911-1918 8 s.

Increasing urine albumin excretion is associated with abnormalities in growth, lower IGF-I, growth hormone hypersecretion and reduced clearance of insulin in young adults with type-1 diabetes: the Oxford Regional Prospective study

Amin, R., Williams, R. M., Frystyk, J., Umpleby, M., Matthews, D., Ørskov, H. C., Dalton, N. D. & Dunger, D. B., 2005, I: Clinical Endocrinology. 62, s. 137-144 8 s.

Influence of insulin-antibodies on insulin pharmacokinetics and pharmacodynamics of multiple injections of biphasic insulin aspart 30 in patients with type 2 diabetes

Chen, J., Frystyk, J., Lauritzen, T. & Sandahl, 2005, I: European Journal of Endocrinology. 153, s. 907-913 7 s.

Insulin-like growth factors (IGFs) and IGF binding proteins in active Crohn’s disease treated with omega-3 or omega-6 fatty acids and corticosteroids.

Eivindson, M., Grønbæk, H., Nielsen, J. N., Frystyk, J., Flyvbjerg, A., Jørgensen, L., Vind, I., Munkholm, P., Jensen, S., Brandslund, I. & Hey, H., 2005, I: Scandinavian Journal of Gastroenterology. 40, s. 1214-21

Pioglitazone treatment increases 24h pulsatile growth hormone (GH) secretion and pyridostigmine GH releasing hormone (GHRH)-stimulated GH levels in polycystic ovary syndrome

Glintborg, D., Støving, R. K., Hagen, C., Hermann, A. P., Frystyk, J., Veldhuis, J., Flyvbjerg, A. & Andersen, M., 2005, I: Journal of Clinical Endocrinology and Metabolism. 90, s. 5605-5612 8 s.

Placental growth hormone, ghrelin and insulin sensitivity index at parturition

Fuglsang, J., Sandager, K. P., Møller, N., Fisker, S., Frystyk, J. & Ovesen, P. G., 2005.

Plasma adiponectin, body mass and mortality in patients with chronic heart failure

Kistorp, C., Faber, J., Galatius, S., Gustafsson, F., Frystyk, J., Flyvbjerg, A. & Hildebrandt, P., 2005, I: Circulation. 112, s. 1756-1762 7 s.

Pro- and mature IGF-II during diet-induced weight loss in obese subjects

Espelund, U., Bruun, J. M., Richelsen, B., Flyvbjerg, A. & Frystyk, J., 2005, I: European Journal of Endocrinology. 153, s. 861-869 9 s.

Somatotropic axis mechanisms and implications of IGFBP adaptation, chapter XI in Aging

Frystyk, J., 2005, I: Endocrinol. Metab. Clin. North. Am.. 34, s. 865-876 12 s.

The IGF-system is not affected by a two-fold change in protein intake in patients with type 1 diabetes

Hedman, C., Frystyk, J., Fridell, K., Flyvbjerg, A., Lindström, T. & Arnquist, H., 2005, I: Growth. Horm. IGF. Res.. 15, s. 304-310 7 s.

The growth hormone hypothesis - the 2005 version

Frystyk, J., 2005, I: Horm. Metab. Res.. 37, Suppl. 1, s. 44-48 5 s.

Changes in free rather than total D: IGF-I insulin-like growth factor-I enhance insulin sensitivity and suppress endogenous peak growth hormone (GH) release following short-term low-dose GH administration in young healthy adults

Yuen, K., Frystyk, J., Umpleby, M., Fryklund, L. & Dunger, D., 2004, I: J. Clin. Endocrinol.. 89, s. 3956-3964 9 s.

Estradiol supplementation potentiates recombinant human IGF-I-enforced suppression of pulsatile and GHRH-stimulated growth hormone secretion in postmenopausal women

Veldhuis, J. D., Anderson, S. M., Kok, P., Iranmanesh, A., Ørskov, H., Frystyk, J. & Keenan, D. M., 2004, I: Journal of Clinical Endocrinology and Metabolism. 89, s. 1312-1318 7 s.

Estradiol supplementation potentiates recombinant human IGF-I-enforced suppression of pulsatile and GHRH-stimulated growth hormone secretion in postmenopausal women

Veldhuis, J. D., Andersen, S. M., Kok, P., Iranmanesh, A., Ørskov, H., Frystyk, J. & Keenan, D. M., 2004, I: Journal of Clinical Endocrinology and Metabolism. 89, s. 1312-1318 7 s.

Free IGF-I, IGFBP-1, and the binary complex of IGFBP-1 and IGF-I are increased during human pregnancy

Skjærbæk, C., Frystyk, J., Ørskov, H. & Flyvbjerg, A., 2004, I: Horm. Metab. Res.. 62, s. 215-220 6 s.

Free IGF-I, IGFBP-1, and the binary complex of IGFBP-1 and IGF-I are increased during human pregnancy

Skjærbæk, C., Frystyk, J., Ørskov, H. & Flyvbjerg, A., 2004, I: Horm. Metab. Res.. 62, s. 215-220 6 s.

Free insulin-like growth factors - measurements and relationships to growth hormone secretion and glucose homeostasis

Frystyk, J., 2004, I: Growth. Horm. IGF. Res.. 14, s. 337-375 39 s.

Residual-cell function more than glycemic control determines abnormalities of the IGF-system in type 1 diabetes

Hedman, C. A., Frystyk, J., Lindstrøm, T., Chen, J. W., Flyvbjerg, A., Ørskov, H. & Arnqvist, H. J., 2004, I: Journal of Clinical Endocrinology and Metabolism. 89, s. 6305-6309 5 s.

Residual-cell function more than glycemic control determines abnormalities of the IGF-system in type 1 diabetes

Hedman, C. A., Frystyk, J., Lindström, T., Chen, J. W., Flyvbjerg, A., Ørskov, H. & Arnqvist, H. J., 2004, I: Journal of Clinical Endocrinology and Metabolism. 89, s. 6305-6309 5 s.

Serum adiponectin levels in adults with Prader-Willi Syndrome do not change during growth hormone treatment

Höybye, C., Bruun, J. M., Richelsen, B., Flyvbjerg, A. & Frystyk, J., 2004, I: European Journal of Endocrinology. 151, s. 457-461 5 s.

Serum adiponectin levels in adults with Prader-Willi syndrome are independent of anthropometrical parameters and do not change with GH treatment

Höybye, C., Bruun, J. M., Richelsen, B., Flyvbjerg, A. & Frystyk, J., 2004, I: European Journal of Endocrinology. 151, 4, s. 457-461 5 s.

Short-term low dose growth hormone administration in subjects with impaired glucose tolerance and the metabolic syndrome: effects on β-cell function and post-load glucose tolerance

Yuen, K., Wareham, N., Frystyk, J., Hennings, S., Mitchell, J., Fryklund, L. & Dunger, D., 2004, I: European Journal of Endocrinology. 151, s. 39-45 7 s.

The effect of long-term somatostatin analogue treatment on free and total insulin-like growth factor (IGF) I, -II and IGF binding protein 1, -2 and -3 serum levels in euthyroid patients with active thyroid eye disease

Krassas, G. E., Pontikides, N., Dumas, A., Frystyk, J., Wen, C. J. & Flyvbjerg, A., 2004, I: Hormones. 3, s. 191-197 7 s.

The effect of long-term somatostatin analogue treatment on free and total insulin-like growth factor (IGF) I, -II and IGF binding protein 1,-2 and -3 serum levels in euthyroid patients with active thyroid eye disease

Krassas, G. E., Pontikides, N., Dumas, A., Frystyk, J., Wen, C. J. & Flyvbjerg, A., 2004, I: Hormones. 3, s. 191-197 7 s.

hIGFBP-1 increases serum growth hormone in mice

Cingel-Ristic, V., van Neck, J. W., Frystyk, J., Drop, S. L. S. & Flyvbjerg, A., 2004, I: Endokrinologiya. 145, s. 4401-4407 7 s.

hIGFBP-1 increases serum growth hormone in mice

Cingel-Ristic, V., van Neck, J. W., Frystyk, J., Drop, S. L. S. & Flyvbjerg, A., 2004, I: Endokrinologiya. 145, s. 4401-4407 7 s.

A highly sensitive and specific assay for determination of IGF-I bioactivity in human serum

Chen, J. W., Ledet, T., Ørskov, H., Jessen, N., Lund, S., Whittaker, J., De Meyts, P., Larsen, M. B., Christiansen, J. S. & Frystyk, J., 2003, I: Am. J. Physiol. Endocrinol. Metab.. 284, 6, s. 1149-1155 7 s.

Assessment of ghrelin

Espelund, U., Hansen, T. K., Ørskov, H. & Frystyk, J., 2003, I: Acta Pathologica Microbiologica et Immunologica Scandinavica. suppl. 109, s. 140-145 6 s.

Development of acromegaly in patients with prolactinomas

Andersen, M., Hagen, C., Frystyk, J., Schroeder, H. D. & Hagen, C., 2003, I: European Journal of Endocrinology. 149, 1, s. 17-22 6 s.

Effects of growth hormone and feeding level on endocrine measurements, hormone receptors, muscle growth and performance of prepubertal heifers

Vestergaard, M., Purup, S., Frystyk, J., Løvendahl, P., Sørensen, M. T., Riis, P. M., Flint, D. J. & Sejrsen, K., 2003, I: Journal Anim Sci. 81, 9, s. 2189-2198 10 s.

Free and total insulin-like growth factor (IGF)-I, -II, and IGF binding protein-1, -2, and -3 serum levels in patients with active thyroid eye disease

Krassas, G. E., Pontikides, N., Kaltsas, T., Dumas, A., Frystyk, J., Chen, J. W. & Flyvbjerg, A., 2003, I: Journal of Clinical Endocrinology and Metabolism. 88, 1, s. 132-135 4 s.

Low IGF-I and elevated testosterone during puberty in subjects with type 1 diabetes developing microalbuminuria in comparison to normoalbuminuric control subjects: the Oxford Regional Prospective Study

Amin, R., Schultz, C., Ong, K., Frystyk, J., Dalton, R. N., Perry, L., Ørskov, H. & Dunger, D. B., 2003, I: Diabetes Care. 26, 5, s. 1456-1461 6 s.

Low IGF-I and elevated testosterone during puberty in subjects with type 1 diabetes developing microalbuminuria in comparison to normoalbuminuric control subjects: the Oxford Regional Prospective Study

Amin, R., Schultz, C., Ong, K., Frystyk, J., Dalton, R. N., Perry, L., Ørskov, H., Dunger, D. B. & nullRegionalProspectiveStudy, O., 2003, I: Diabetes Care. 26, 5, s. 1456-1461 6 s.

Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease

Frystyk, J., Ledet, T., Møller, N., Flyvbjerg, A. & Ørskov, H., 2003, I: Circulation. 107, s. 0-0 193 s.

Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease

Boger, R. H., Frystyk, J., Ledet, T., Møller, N., Flyvbjerg, A. & Ørskov, H., 2003, I: Circulation. 107, 20, s. 193-193 1 s.

Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease

Boger, R. H., Frystyk, J., Ledet, T., Møller, N., Flyvbjerg, A. & Ørskov, H., 2003, I: Circulation. 107, 20, s. 193-193 1 s.

Splanchnic release of ghrelin in humans

Møller, N., Nygren, J., Hansen, T. K., Ørskov, H., Frystyk, J. & Nair, K. S., 2003, I: Journal of Clinical Endocrinology and Metabolism. 88, 2, s. 850-852 3 s.

The circulating IGF system and its relationship with 24-h glucose regulation and insulin sensitivity in healthy subjects

Frystyk, J., Nyholm, B., Skjærbæk, C., Baxter, R. C., Schmitz, O. & Ørskov, H., 2003, I: Clinical Endocrinology. 58, 6, s. 777-784 8 s.

The decisive role of free fatty acids for protein conservation during fasting in humans with and without growth hormone

Nørrelund, H., Nair, K. S., Nielsen, S., Frystyk, J., Ivarsen, P., Jørgensen, J. O. L., Christiansen, J. S. & Møller, N., 2003, I: Journal of Clinical Endocrinology and Metabolism. 88, 9, s. 4371-4378 8 s.

The effect of growth hormone on the insulin-like growth factor system during fasting

Nørrelund, H., Frystyk, J., Jørgensen, J. O., Møller, N., Christiansen, J. S., Ørskov, H. & Flyvbjerg, A., 2003, I: Journal of Clinical Endocrinology and Metabolism. 88, 7, s. 3292-3298 7 s.

The growth hormone-insulin-like growth factor axis in adult patients with Prader Willi syndrome

Hoybye, D., Frystyk, J. & Thoren, M., 2003, I: Growth. Horm. IGF. Res.. 13, 5, s. 269-274 6 s.

The relationship between the circulating IGF system and the presence of retinopathy in Type 1 diabetic patients

Frystyk, J., Bek, T., Flyvbjerg, A., Skjærbæk, C. & Ørskov, H., 2003, I: Diabetic Medicine. 20, 4, s. 269-276 8 s.

The relationship between the circulating insulin-like growth factor system and the presence of retinopathy in type 1 diabetic patients

Frystyk, J., Skjærbæk, C., Flyvbjerg, A., Bek, T. & Ørskov, H., 2003, I: Diabet. Med.. 20, s. 269-276 8 s.

Low free and total insulinlike growth factor I (IGF-I) and IGF binding protein-3 levels in chronic inflammatory bowel disease: partial normalization during prednisolone treatment

Grønbek, H., Thøgersen, T., Frystyk, J., Vilstrup, H., Flyvbjerg, A. & Dahlerup, J. F., mar. 2002, I: American Journal of Gastroenterology. 97, 3, s. 673-8 6 s.

Cardiovascular disease and insulin-like growth factor I

Frystyk, J., Ledet, T., Møller, N., Flyvbjerg, A. & Ørskov, H., 2002, I: Circulation. 106, 8, s. 893-895 3 s.

Circulating levels of IGF-1 directly regulate bone growth and density

Yakar, S., Rosen, C. J., Beamer, W. G., Ackert-Bicknell, C. L., Wu, Y., Liu, J. L., Ooi, G. T., Setser, J., Frystyk, J., Boisclair, Y. R. & LeRoith, D., 2002, I: J. Clin. Invest.. 110, 6, s. 771-781 11 s.

Development and clinical evaluation of a novel immunoassay for the binary complex of IGF-I and IGF-binding protein-1 in human serum

Frystyk, J., Højlund, K., Rasmussen, K. N., Jørgensen, S. P., Wildner-Christensen, M. & Ørskov, H., 2002, I: Journal of Clinical Endocrinology and Metabolism. 87, 1, s. 260-266 7 s.

Effects of octreotide on serum insulin-like growth factor I and insulin-like growth factor binding proteins in patients with cirrhosis

Ottesen, L. H., Frystyk, J., Kiszka-Kanowitz, M., Grønbæk, H., Bendtsen, F. & Flyvbjerg, A., 2002, I: Scandinavian Journal of Clinical & Laboratory Investigation. 62, 16, s. 39-47 9 s.

Indirect evidence for decreased hypothalamic somatostatinergic tone in anorexia nervosa

Stoving, R. K., Andersen, M., Flyvbjerg, A., Frystyk, J., Hangaard, J., Vinten, J., Koldkjær, O. G. & Hagen, C., 2002, I: Clinical Endocrinology. 56, 3, s. 391-396 6 s.

Low free and total insulinlike growth factor I (IGF-I) and IGF binding protein-3 levels in chronic inflammatory bowel disease: partial normalization during prednisolone treatment

Grønbæk, H., Thøgersen, T., Frystyk, J., Vilstrup, H., Flyvbjerg, A. & Dahlerup, J. F., 2002, I: Am J Gastroenterol. 97, 3, s. 673-678 6 s.

Measurement of IGF-I bioactivity in humans

Frystyk, J., Flyvbjerg, A., Lamberts, S. W. J. (red.) & Ghigo, E. (red.), 2002, The Expanding role of Octreotide. Woodlands, Bristol: Bioscientifica, s. 225-234 10 s.

Physical capacity influences the response of insulin-like growth factor and its binding proteins to training

Rosendal, L., Langberg, H., Flyvbjerg, A., Frystyk, J., Ørskov, H. & Kjær, M., 2002, I: J. Appl. Physiol.. 93, 5, s. 1669-1675 7 s.

Determination of free insulin-like growth factor-I in human serum: comparison of ultrafiltration and direct immunoradiometric assay

Frystyk, J., Ivarsen, P., Stoving, R. K., Dall, R., Bek, T., Hagen, C. & Ørskov, H., 2001, I: Growth. Horm. IGF. Res.. 11, 2, s. 117-127 11 s.

Liver-specific IGF-I gene deletion leads to muscle insulin insensitivity

Yakar, S., Liu, J. L., Fernandez, A. M., Wu, Y., Schally, A. V., Frystyk, J., Chernausek, S. D., Mejia, W. & Le Roith, D., 2001, I: Diabetes. 50, 5, s. 1110-1118 9 s.

Reduced free IGF-I and increased IGFBP-3 proteolysis in Turner syndrome: modulation by female sex steroids

Gravholt, C. H., Frystyk, J., Flyvbjerg, A., Ørskov, H. & Christiansen, J. S., 2001, I: American Journal of Physiology: Endocrinology and Metabolism. 280, 2, s. E308-14

Circadian variation in serum free and total insulin-like growth factor (IGF)-I and IGF-II in untreated and treated acromegaly and growth hormone deficiency.

Skjaerbaek, C., Frystyk, J., Kaal, A., Laursen, T., Møller, J., Weeke, J., Jørgensen, J. O. L., Christiansen, J. S. & Ørskov, H., 2000, I: Clinical Endocrinology. 52, 1, s. 25-33 9 s.

Effects of heparin on renal morphology and albuminuria in experimental diabetes

Marshall, S. M., Hansen, K. W., Østerby, R., Frystyk, J., Ørskov, H., Flyvbjerg, A., Gambaro, G. & Baggio, B., 1 dec. 1998, I: American Journal of Physiology. 274, 1 PART 1, s. E192-E193

Differential changes in free and total insulin-like growth factor I after major, elective abdominal surgery: the possible role of insulin-like growth factor-binding protein-3 proteolysis

Skjærbæk, C., Frystyk, J., Ørskov, H., Kissmeyer-Nielsen, P., Jensen, M. B., Laurberg, S., Møller, N. & Flyvbjerg, A., jul. 1998, I: Journal of Clinical Endocrinology and Metabolism. 83, 7, s. 2445-2449 5 s.

Letter to the editor (multiple letters)

Gambaro, G., Baggio, B., Marshall, S. M., Hansen, K. W., Osterby, R., Frystyk, J., Orskov, H. & Flyvbjerg, A., 1 jan. 1998, I: American Journal of Physiology - Endocrinology and Metabolism. 274, 1 37-1, s. E192-E193

Effects of heparin on renal morphology and albuminuria in experimental diabetes

Marshall, S. M., Hansen, K. W., Osterby, R., Frystyk, J., Orskov, H. & Flyvbjerg, A., aug. 1996, I: American Journal of Physiology (Consolidated). 271, 2 Pt 1, s. E326-32

Systemic and regional tumour metabolism in a patient with non-islet cell tumour hypoglycaemia: role of increased levels of free insulin-like growth factors.

Møller, N., Frystyk, J., Skjaerbaek, C., Pedersen, H. B., Christensen, C., Schmitz, O., Gee, A., Gjedde, A., Zapf, J. & Ørskov, H., 1996, I: Diabetologia. 39, 12, s. 1534-5 1 s.

Growth hormone dose regimens in adult GH deficiency: effects on biochemical growth markers and metabolic parameters.

Møller, J., Jørgensen, J. O. L., Laursen, T., Frystyk, J., Naeraa, R. W., Ørskov, H. & Christiansen, J. S., 1993, I: Clinical Endocrinology. 39, 4, s. 403-408 6 s.

Octreotide administration in diabetic rats: Effects on renal hypertrophy and urinary albumin excretion

Flyvbjerg, A., Marshall, S. M., Frystyk, J., Hansen, K. W., Harris, A. G. & Ørskov, H., 1 jan. 1992, I: Kidney International. 41, 4, s. 805-812 8 s.

Somatostatin analogue administration prevents increase in kidney somatomedin C and initial renal growth in diabetic and uninephrectomized rats

Flyvbjerg, A., Frystyk, J., Thorlacius-Ussing, O. & Orskov, H., 1989, I: Diabetologia. 32, 4, s. 261-5 4 s.