Institut for Biomedicin

Jan Asad

Translational control in brain pathologies: biological significance and therapeutic opportunities

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

DOI

  • Alberto Delaidelli, British Columbia Cancer Research Centre, University of British Columbia
  • ,
  • Asad Jan
  • Jochen Herms, Ludwig-Maximilians-University München, German Center for Neurodegenerative Diseases DZNE
  • ,
  • Poul H. Sorensen, British Columbia Cancer Research Centre, University of British Columbia

Messenger RNA (mRNA) translation is the terminal step in protein synthesis, providing a crucial regulatory checkpoint for this process. Translational control allows specific cell types to respond to rapid changes in the microenvironment or to serve specific functions. For example, neurons use mRNA transport to achieve local protein synthesis at significant distances from the nucleus, the site of RNA transcription. Altered expression or functions of the various components of the translational machinery have been linked to several pathologies in the central nervous system. In this review, we provide a brief overview of the basic principles of mRNA translation, and discuss alterations of this process relevant to CNS disease conditions, with a focus on brain tumors and chronic neurological conditions. Finally, synthesizing this knowledge, we discuss the opportunities to exploit the biology of altered mRNA translation for novel therapies in brain disorders, as well as how studying these alterations can shed new light on disease mechanisms.

OriginalsprogEngelsk
TidsskriftActa Neuropathologica
Vol/bind137
Nummer4
Sider (fra-til)535-555
Antal sider21
ISSN0001-6322
DOI
StatusUdgivet - apr. 2019

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