Jan Alsner

Chefkonsulent

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Jan Alsner

Chefkonsulent

  • Institut for Klinisk Medicin - Eksperimentel Klinisk Onkologi
Postaddresse:
Palle Juul-Jensens Boulevard 35
8200
Aarhus N
Danmark

E-mail: jan@oncology.au.dk

Mobil: +4561300131

Publikationer

Correlation and prognostic impact of human papilloma virus and p16-expression in advanced hypopharynx and larynx cancer treated with definitive radiotherapy

Lassen, P., Schou, M., Overgaard, J. & Alsner, J., maj 2021, I: Acta Oncologica. 60, 5, 3 s.

Risk of coronary artery disease after adjuvant radiotherapy in 29,662 early breast cancer patients: A population-based Danish Breast Cancer Group study

Milo, M. L. H., Thorsen, L. B. J., Paaske Johnsen, S., Nielsen, K. M., Brink Valentin, J., Alsner, J. & Offersen, B. V., apr. 2021, I: Radiotherapy & Oncology. 157, s. 106-113 8 s.

Patient-reported outcomes in postmenopausal breast cancer survivors–comparisons with normative data

Nielsen, A. W. M., Kristensen, M. H., Offersen, B. V., Alsner, J., Zachariae, R. & Nielsen, H. M., jan. 2021, I: Acta Oncologica. 60, 1, s. 78-86 9 s.

Hypofractionated Versus Standard Fractionated Radiotherapy in Patients With Early Breast Cancer or Ductal Carcinoma In Situ in a Randomized Phase III Trial: The DBCG HYPO Trial

Offersen, B. V., Alsner, J., Nielsen, H. M., Jakobsen, E. H., Nielsen, M. H., Krause, M., Stenbygaard, L., Mjaaland, I., Schreiber, A., Kasti, U. M., Overgaard, J. & Danish Breast Cancer Group Radiation Therapy Committee, nov. 2020, I: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 38, 31, s. 3615-3625 11 s.

Incidence and Mortality of Second Primary Cancers in Danish Patients With Retinoblastoma, 1943-2013

Gregersen, P. A., Olsen, M. H., Urbak, S. F., Funding, M., Dalton, S. O., Overgaard, J. & Alsner, J., okt. 2020, I: JAMA network open. 3, 10, 12 s., e2022126.

Patient-reported outcome measures used for reporting late effects in postmenopausal breast cancer survivors and compared to general symptoms in a Danish female age matched population

Nielsen, A. W. M., Kristensen, M. H., Offersen, B. V., Alsner, J., Zachariae, R. & Nielsen, H. M., okt. 2020, s. S90.

Specific requirements for translation of biological research into clinical radiation oncology

Krause, M., Alsner, J., Linge, A., Bütof, R., Löck, S. & Bristow, R., jul. 2020, I: Molecular Oncology. 14, 7, s. 1569-1576 8 s.

Dose response modifiers in radiation therapy

Horsman, M. R., Lindegaard, J. C., Grau, C., Nordsmark, M., Alsner, J. & Overgaard, J., 15 feb. 2020, Gunderson and Tepper's Clinical Radiation Oncology 5th Edition. Gundersen, LL. & Tepper, JE. (red.). 5 udg. Philadelfia, PA, USA: Elsevier, s. 48-60

Characterization and radiosensitivity of HPV-related oropharyngeal squamous cell carcinoma patient-derived xenografts

Lilja-Fischer, J. K., Ulhøi, B. P., Alsner, J., Stougaard, M., Thomsen, M. S., Busk, M., Lassen, P., Steiniche, T., Nielsen, V. E. & Overgaard, J., okt. 2019, I: Acta Oncologica. 58, 10, s. 1489-1494 6 s.

HPV, tobacco smoking and specific mutations and amplifications in oropharyngeal cancer

Lilja-Fischer, J. K., Ulhøi, B. P., Stougaard, M., Lassen, P., Steiniche, T., Alsner, J. & Overgaard, J., 12 mar. 2019.

Effect of ESA as a modifier of radiotherapy in curative intended treatment of squamous cell carcinoma of the head and neck (HNSCC)

Overgaard, J. & Alsner, J., jan. 2019, I: Radiotherapy & Oncology. 130, s. 191-192 2 s.

Comparison of Coding Transcriptomes in Fibroblasts Irradiated With Low and High LET Proton Beams and Cobalt-60 Photons

Nielsen, S., Bassler, N., Grzanka, L., Laursen, L., Swakon, J., Olko, P., Andreassen, C. N., Alsner, J. & Singers Sørensen, B., 2019, I: International Journal of Radiation Oncology Biology Physics. 103, 5, s. 1203-1211 9 s.

IMRT – Biomarkers for dose escalation, dose de-escalation and personalized medicine in radiotherapy for head and neck cancer

Andreassen, C. N., Eriksen, J. G., Jensen, K., Hansen, C. R., Sørensen, B. S., Lassen, P., Alsner, J., Schack, L. M. H., Overgaard, J. & Grau, C., 1 nov. 2018, I: Oral Oncology. 86, s. 91-99 9 s.

Strålefølsomhed hos patienter med hoved-halskræft

Lilja-Fischer, J. K., Ulhøi, B. P., Stougaard, M., Lassen, P., Thomsen, M. S., Nielsen, V. E., Steiniche, T., Alsner, J. & Overgaard, J., 30 okt. 2018.

Associations between skin rash, treatment outcome, and single nucleotide polymorphisms in head and neck cancer patients receiving the EGFR-inhibitor zalutumumab: results from the DAHANCA 19 trial

Brøndum, L., Alsner, J., Sørensen, B. S., Maare, C., Johansen, J., Primdahl, H., Evensen, J. F., Kristensen, C. A., Andersen, L. J., Overgaard, J. & Eriksen, J. G., sep. 2018, I: Acta Oncologica. 57, 9, s. 1159-1164 6 s.

Optimal reference genes for normalization of qPCR gene expression data from proton and photon irradiated dermal fibroblasts

Nielsen, S., Bassler, N., Grzanka, L., Swakon, J., Olko, P., Andreassen, C. N., Alsner, J. & Sørensen, B. S., 23 aug. 2018, I: Scientific Reports. 8, 1, 7 s., 12688.

DAHANCA 10 - Effect of darbepoetin alfa and radiotherapy in the treatment of squamous cell carcinoma of the head and neck. A multicenter, open-label, randomized, phase 3 trial by the Danish head and neck cancer group

Overgaard, J., Hoff, C. M., Hansen, H. S., Specht, L., Overgaard, M., Lassen, P., Andersen, E., Johansen, J., Andersen, L. J., Evensen, J. F., Alsner, J. & Grau, C., 1 apr. 2018, I: Radiotherapy & Oncology. 127, 1, s. 12-19 8 s.

Impact of tobacco smoking on muta?onal landscape in HPV-associated oropharyngeal cancer

Lilja-Fischer, J. K., Ulhøi, B. P., Stougaard, M., Lassen, P., Nielsen, V. E., Steiniche, T., Alsner, J. & Overgaard, J., 15 feb. 2018.

Characterization and radiosensitivity of HPV-related oropharyngeal squamous cell carcinoma patient-derived xenografts

Lilja-Fischer, J. K., Ulhøi, B. P., Stougaard, M., Lassen, P., Thomsen, M. S., Nielsen, V. E., Steiniche, T., Alsner, J. & Overgaard, J., 14 feb. 2018.

Influence of intra-tumoral heterogeneity on the evaluation of BCL2, E-cadherin, EGFR, EMMPRIN, and Ki-67 expression in tissue microarrays from breast cancer

Tramm, T., Kyndi, M., Sørensen, F. B., Overgaard, J. & Alsner, J., jan. 2018, I: Acta Oncologica. 57, 1, s. 102-106 5 s.

Intrinsic subtypes and benefit from postmastectomy radiotherapy in node-positive premenopausal breast cancer patients who received adjuvant chemotherapy - results from two independent randomized trials

Laurberg, T., Tramm, T., Nielsen, T., Alsner, J., Nord, S., Myhre, S., Sørlie, T., Leung, S., Fan, C., Perou, C., Gelmon, K., Overgaard, J., Voduc, D., Prat, A. & Cheang, M. C. U., jan. 2018, I: Acta Oncologica. 57, 1, s. 38-43 6 s.

Tumour-infiltrating lymphocytes predicts improved overall survival after post-mastectomy radiotherapy

Tramm, T., Vinter, H., Alsner, J. & Overgaard, J., 2018, I: Radiotherapy & Oncology. 127, s. S312-S313 2 s., OC-0597.

Differential gene expression in primary fibroblasts induced by proton and cobalt-60 beam irradiation

Nielsen, S., Bassler, N., Grzanka, L., Swakon, J., Olko, P., Andreassen, C. N., Overgaard, J., Alsner, J. & Sørensen, B. S., nov. 2017, I: Acta Oncologica. 56, 11, s. 1406-1412 7 s.

Rethink radiotherapy - BIGART 2017

Grau, C., Høyer, M., Poulsen, P. R., Muren, L. P., Korreman, S. S., Tanderup, K., Lindegaard, J. C., Alsner, J. & Overgaard, J., nov. 2017, I: Acta Oncologica. 56, 11, s. 1341-1352 12 s.

Validation of genetic predictors of late radiation-induced morbidity in prostate cancer patients

Schack, L. M. H., Petersen, S. E., Nielsen, S., Lundby, L., Høyer, M., Bentzen, L., Overgaard, J., Andreassen, C. N. & Alsner, J., nov. 2017, I: Acta Oncologica. 56, 11, s. 1514-1521 8 s.

A Gene Signature for Selecting Benefit from Hypoxia Modification of Radiotherapy for High-Risk Bladder Cancer Patients

Yang, L., Taylor, J., Eustace, A., Irlam, J. J., Denley, H., Hoskin, P. J., Alsner, J., Buffa, F. M., Harris, A. L., Choudhury, A. & West, C. M. L., 15 aug. 2017, I: Clinical Cancer Research. 23, 16, s. 4761-4768 8 s.

Oropharyngeal cancer patient-derived xenografts: Characterization and radiosensivity

Lilja-Fischer, J. K., Ulhøi, B. P., Stougaard, M., Lassen, P., Nielsen, V. E., Steiniche, T., Alsner, J. & Overgaard, J., 13 jun. 2017.

Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome

Aure, M. R., Vitelli, V., Jernström, S., Kumar, S., Krohn, M., Due, E. U., Haukaas, T. H., Leivonen, S-K., Vollan, H. K. M., Lüders, T., Rødland, E., Vaske, C. J., Zhao, W., Møller, E. K., Nord, S., Giskeødegård, G. F., Bathen, T. F., Caldas, C., Tramm, T., Alsner, J., Overgaard, J., Geisler, J., Bukholm, I. R. K., Naume, B., Schlichting, E., Sauer, T., Mills, G. B., Kåresen, R., Mælandsmo, G. M., Lingjærde, O. C., Frigessi, A., Kristensen, V. N., Børresen-Dale, A-L., Sahlberg, K. K. & OSBREAC, 29 mar. 2017, I: Breast Cancer Research. 19, 1, 18 s., 44.

Oropharyngeal cancer patient-derived xenografts: Characterization and radiosensitivity

Lilja-Fischer, J. K., Ulhøi, B. P., Alsner, J., Lassen, P., Nielsen, V. E. & Overgaard, J., 16 mar. 2017.

Plasma proteins as prognostic biomarkers in radiotherapy treated head and neck cancer patients

Brøndum, L., Eriksen, J. G., Singers Sørensen, B., Mortensen, L. S., Toustrup, K., Overgaard, J. & Alsner, J., feb. 2017, I: Clinical and Translational Radiation Oncology. 2, s. 46-52 7 s.

Impact of age, intrinsic subtype and local treatment on long-term local-regional recurrence and breast cancer mortality among low-risk breast cancer patients

Laurberg, T., Alsner, J., Tramm, T., Jensen, V., Lyngholm, C. D., Christiansen, P. M. & Overgaard, J., jan. 2017, I: Acta Oncologica. 56, 1, s. 59-67 9 s.

HPV status, cancer stem cell marker expression, hypoxia gene signatures and tumour volume identify good prognosis subgroups in patients with HNSCC after primary radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG)

Linge, A., Lohaus, F., Löck, S., Nowak, A., Gudziol, V., Valentini, C., von Neubeck, C., Jütz, M., Tinhofer, I., Budach, V., Sak, A., Stuschke, M., Balermpas, P., Rödel, C., Grosu, A-L., Abdollahi, A., Debus, J., Ganswindt, U., Belka, C., Pigorsch, S., Combs, S. E., Mönnich, D., Zips, D., Buchholz, F., Aust, D. E., Baretton, G. B., Thames, H. D., Dubrovska, A., Alsner, J., Overgaard, J., Krause, M., Baumann, M. & DKTK-ROG, dec. 2016, I: Radiotherapy & Oncology. 121, 3, s. 364-373 10 s.

Radiation-induced morbidity evaluated by high-frequency ultrasound

Schack, L. M. H., Alsner, J., Overgaard, J., Andreassen, C. N. & Offersen, B. V., dec. 2016, I: Acta Oncologica. 55, 12, s. 1498-1500 3 s.

The relative biological effectiveness of antiprotons

Holzscheiter, M. H., Alsner, J., Bassler, N., Boll, R., Caccia, M., Knudsen, H., Maggiore, C., Petersen, J. B., Sellner, S., Strasse, T., Sørensen, B. S. & Overgaard, J., dec. 2016, I: Radiotherapy & Oncology. 121, 3, s. 453-458 6 s.

Establishment and characterisation of oropharyngeal cancer patient-derived xenografts as a model for radiation research.

Lilja-Fischer, J. K., Ulhøi, B. P., Alsner, J., Lassen, P., Nielsen, V. E. & Overgaard, J., 3 nov. 2016.

A prognostic profile of hypoxia-induced genes for localised high-grade soft tissue sarcoma

Aggerholm-Pedersen, N., Sørensen, B. S., Overgaard, J., Toustrup, K., Bærentzen, S., Nielsen, O. S., Maretty-Kongstad, K., Nordsmark, M., Alsner, J. & Safwat, A., 25 okt. 2016, I: B J C. 115, 9, s. 1096-1104 9 s.

An evaluation of multiplex bead-based analysis of cytokines and soluble proteins in archived lithium heparin plasma, EDTA plasma and serum samples

Brøndum, L., Sørensen, B. S., Eriksen, J. G., Mortensen, L. S., Lønbro, S., Overgaard, J. & Alsner, J., 26 sep. 2016, I: Scandinavian Journal of Clinical & Laboratory Investigation. 76, 8, s. 601-611 11 s.

Radiogenomics - current status, challenges and future directions

Andreassen, C. N., Schack, L. M. H., Laursen, L. V. & Alsner, J., 1 sep. 2016, I: Cancer Letters. 382, 1, s. 127-136 10 s.

Integrative Analysis of DCE-MRI and Gene Expression Profiles in Construction of a Gene Classifier for Assessment of Hypoxia-Related Risk of Chemoradiotherapy Failure in Cervical Cancer

Fjeldbo, C. S., Julin, C. H., Lando, M., Forsberg, M. F., Aarnes, E-K., Alsner, J., Kristensen, G. B., Malinen, E. & Lyng, H., 15 aug. 2016, I: Clinical Cancer Research. 22, 16, s. 4067-76 10 s.

Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients

Andreassen, C. N., Rosenstein, B. S., Kerns, S. L., Ostrer, H., De Ruysscher, D., Cesaretti, J. A., Barnett, G. C., Dunning, A. M., Dorling, L., West, C. M. L., Burnet, N. G., Elliott, R., Coles, C., Hall, E., Fachal, L., Vega, A., Gómez-Caamaño, A., Talbot, C. J., Symonds, R. P., De Ruyck, K., Thierens, H., Ost, P., Chang-Claude, J., Seibold, P., Popanda, O., Overgaard, M., Dearnaley, D., Sydes, M. R., Azria, D., Koch, C. A., Parliament, M., Blackshaw, M., Sia, M., Fuentes-Raspall, M. J., Ramon Y Cajal, T., Barnadas, A., Vesprini, D., Gutiérrez-Enríquez, S., Mollà, M., Díez, O., Yarnold, J. R., Overgaard, J., Bentzen, S. M., Alsner, J. & International Radiogenomics Consortium (RgC), 18 jul. 2016, I: Radiotherapy & Oncology.

Long-term age-dependent failure pattern after breast-conserving therapy or mastectomy among Danish lymph-node-negative breast cancer patients

Laurberg, T., Lyngholm, C. D., Christiansen, P., Alsner, J. & Overgaard, J., 8 jun. 2016, I: Radiotherapy & Oncology. 120, 1, s. 98-106 9 s.

Low Cancer Stem Cell Marker Expression and Low Hypoxia Identify Good Prognosis Subgroups in HPV(-) HNSCC after Postoperative Radiochemotherapy: A Multicenter Study of the DKTK-ROG

Linge, A., Löck, S., Gudziol, V., Nowak, A., Lohaus, F., von Neubeck, C., Jütz, M., Abdollahi, A., Debus, J., Tinhofer, I., Budach, V., Sak, A., Stuschke, M., Balermpas, P., Rödel, C., Avlar, M., Grosu, A-L., Bayer, C., Belka, C., Pigorsch, S., Combs, S. E., Welz, S., Zips, D., Buchholz, F., Aust, D. E., Baretton, G. B., Thames, H. D., Dubrovska, A., Alsner, J., Overgaard, J., Baumann, M., Krause, M. & DKTK-ROG, 1 jun. 2016, I: Clinical Cancer Research. 22, 11, s. 2639-49 11 s.

Validation of a 15-gene hypoxia classifier in head and neck cancer for prospective use in clinical trials

Toustrup, K., Sørensen, B. S., Metwally, M. A. H., Tramm, T., Mortensen, L. S., Overgaard, J. & Alsner, J., 10 maj 2016, I: Acta Oncologica. 55, 9-10, s. 1091-1098 8 s.

Prognostic value of hypoxia-regulated gene expression in loco-regional gastroesophageal cancer

Winther, M., Alsner, J., Tramm, T., Holtved, E., Baeksgaard, L. & Nordsmark, M., maj 2016, I: Acta Oncologica. 55, 5, s. 652-5 4 s.

Failure pattern and survival after breast conserving therapy. Long-term results of the Danish Breast Cancer Group (DBCG) 89 TM cohort

Lyngholm, C. D., Laurberg, T., Alsner, J., Damsgaard, T. E., Overgaard, J. & Christiansen, P., 27 apr. 2016, I: Acta Oncologica. 55, 8, s. 983-992 10 s.

Gene-expression Classifier in Papillary Thyroid Carcinoma: Validation and Application of a Classifier for Prognostication

Londero, S. C., Jespersen, M. L., Krogdahl, A., Bastholt, L., Overgaard, J., Schytte, S., Godballe, C., Alsner, J. & The Danish Thyroid Cancer Group – DATHYRCA (part of the DAHANCA organization), feb. 2016, I: Anticancer Research. 36, 2, s. 749-56 8 s.

Hypoxia-regulated microRNAs in gastroesophageal cancer

Winther, M., Alsner, J., Sørensen, B. S., Wittrup, C. F., Tramm, T., Beaksgaard, L., Hofland, K., Holtved, E. & Nordsmark, M., feb. 2016, I: Anticancer Research. 36, 2, s. 721-30 10 s.

Clinical Impact of a Novel MicroRNA Chemo-Sensitivity Predictor in Gastrooesophageal Cancer

Winther, M., Knudsen, S., Dahlgaard, J., Jensen, T., Hansen, A., Jensen, P. B., Tramm, T., Alsner, J. & Nordsmark, M., 2016, I: P L o S One. 11, 2, 8 s., e0148070.

Differential protein expression of peroxiredoxin-1 in classical Hodgkin Lymphoma: a possible correlation to clinical behaviour

Ludvigsen, M., Kamper, P., Sørensen, B. S., Møller, M. B., Bendix, K., Hamilton-Dutoit, S. J., Alsner, J., D'Amore, F. A. & Honoré, B., dec. 2015, I: Hematological Oncology. 33, s. 253-255

Danish retinoblastoma patients 1943-2013 - genetic testing and clinical implications

Gregersen, P. A., Urbak, S. F., Funding, M., Overgaard, J., Jensen, U. B. & Alsner, J., 23 okt. 2015, I: Acta Oncologica. s. 1-6 6 s.

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

Pettersen, E. O., Ebbesen, P., Gieling, R. G., Williams, K. J., Dubois, L., Lambin, P., Ward, C., Meehan, J., Kunkler, I. H., Langdon, S. P., Ree, A. H., Flatmark, K., Lyng, H., Calzada, M. J., Peso, L. D., Landazuri, M. O., Görlach, A., Flamm, H., Kieninger, J., Urban, G., Weltin, A., Singleton, D. C., Haider, S., Buffa, F. M., Harris, A. L., Scozzafava, A., Supuran, C. T., Moser, I., Jobst, G., Busk, M., Toustrup, K., Overgaard, J., Alsner, J., Pouyssegur, J., Chiche, J., Mazure, N., Marchiq, I., Parks, S., Ahmed, A., Ashcroft, M., Pastorekova, S., Cao, Y., Rouschop, K. M., Wouters, B. G., Koritzinsky, M., Mujcic, H. & Cojocari, D., okt. 2015, I: Journal of Enzyme Inhibition and Medicinal Chemistry. s. 689-721 33 s.

Dose-response modifiers in radiation therapy

Horsman, M. R., Lindegaard, J. C., Grau, C., Nordsmark, M., Alsner, J. & Overgaard, J., 9 sep. 2015, Clinical radiation oncology. Gundersen, LL. & Tepper, JE. (red.). 4 udg. Philadelphia, PA, USA: Elsevier, s. 51-62 12 s.

The usability of a 15-gene hypoxia classifier as a universal hypoxia profile in various cancer cell types

Sørensen, B. S., Knudsen, A. B., Wittrup, C. F., Nielsen, S., Aggerholm-Pedersen, N., Busk, M., Horsman, M., Høyer, M., Bouchelouche, P. N., Overgaard, J. & Alsner, J., sep. 2015, I: Radiotherapy & Oncology. 116, 3, s. 346-51 6 s.

Implementation of a 15-gene hypoxia classifier in Head and Neck Cancer

Sørensen, B. S., Toustrup, K., Eriksen, J. G., Overgaard, J. & Alsner, J., 27 aug. 2015.

Validation of a gene expression profile predictive of the risk of radiation-induced fibrosis in women treated with breast conserving therapy

Lyngholm, C. D., Overgaard, J., Christiansen, P. M. & Alsner, J., 12 aug. 2015, I: Acta Oncologica. s. 1-4 4 s.

Evaluation of miR-21 and miR-375 as prognostic biomarkers in esophageal cancer

Winther, M., Alsner, J., Tramm, T., Baeksgaard, L., Holtved, E. & Nordsmark, M., 2015, I: Acta oncologica (Stockholm, Sweden). 54, 9, s. 1582-91 10 s.

Relative biological effectiveness of carbon ions for tumor control, acute skin damage and late radiation-induced fibrosis in a mouse model

Sørensen, B. S., Horsman, M. R., Alsner, J., Overgaard, J., Durante, M., Scholz, M., Friedrich, T. & Bassler, N., 2015, I: Acta Oncologica. 54, 9, s. 1623-1630 8 s.

Simultaneous Hypoxia and Low Extracellular pH Suppress Overall Metabolic Rate and Protein Synthesis In Vitro

Sørensen, B. S., Busk, M., Overgaard, J., Horsman, M. R. & Alsner, J., 2015, I: PLOS ONE. 10, 8, 14 s., e0134955.

The importance of reference gene analysis of formalin-fixed, paraffin-embedded samples from sarcoma patients - an often underestimated problem

Aggerholm-Pedersen, N., Safwat, A. A., Bærentzen, S., Nordsmark, M., Nielsen, O. S., Alsner, J. & Sørensen, B. S., dec. 2014, I: Translational Oncology. 7, 6, s. 687-93 7 s.

Effect of radiation on cell proliferation and tumor hypoxia in HPV-positive head and neck cancer in vivo models

Sørensen, B. S., Busk, M., Horsman, M. R., Alsner, J., Overgaard, J., Kyle, A. H. & Minchinton, A. I., nov. 2014, I: Anticancer Research. 34, 11, s. 6297-304 8 s.

Development and validation of a gene profile predicting benefit of postmastectomy radiotherapy in patients with high-risk breast cancer: a study of gene expression in the DBCG82bc cohort

Tramm, T., Mohammed, H., Myhre, S., Kyndi, M., Alsner, J., Børresen-Dale, A-L., Sørlie, T., Frigessi, A. & Overgaard, J., 15 okt. 2014, I: Clinical Cancer Research. 20, 20, s. 5272-80 9 s.

Relationship between the prognostic and predictive value of the intrinsic subtypes and a validated gene profile predictive of loco-regional control and benefit from post-mastectomy radiotherapy in patients with high-risk breast cancer

Tramm, T., Kyndi, M., Myhre, S., Nord, S., Alsner, J., Sørensen, F. B., Sørlie, T. & Overgaard, J., okt. 2014, I: Acta Oncologica. 53, 10, s. 1337-46 10 s.

Tumor Hypoxia

Nordsmark, M., Busk, M., Petersen, J. B., Alsner, J., Overgaard, J. & Horsman, M. R., 25 jul. 2014, Comprehensive Biomedical Physics: Radiation Therapy Physics and Treatment Optimization. Elsevier, Bind 9. s. 205-222 18 s.

Radiogenomics: radiobiology enters the era of big data and team science

Rosenstein, B. S., West, C. M., Bentzen, S. M., Alsner, J., Andreassen, C. N., Azria, D., Barnett, G. C., Baumann, M., Burnet, N., Chang-Claude, J., Chuang, E. Y., Coles, C. E., Dekker, A., De Ruyck, K., De Ruysscher, D., Drumea, K., Dunning, A. M., Easton, D., Eeles, R., Fachal, L., Gutiérrez-Enríquez, S., Haustermans, K., Henríquez-Hernández, L. A., Imai, T., Jones, G. D. D., Kerns, S. L., Liao, Z., Onel, K., Ostrer, H., Parliament, M., Pharoah, P. D. P., Rebbeck, T. R., Talbot, C. J., Thierens, H., Vega, A., Witte, J. S., Wong, P., Zenhausern, F. & International Radiogenomics Consortium, 15 jul. 2014, I: International Journal of Radiation Oncology, Biology, Physics. 89, 4, s. 709-13 5 s.

Identifying microRNAs regulating B7-H3 in breast cancer: the clinical impact of microRNA-29c

Nygren, M. K., Tekle, C., Ingebrigtsen, V. A., Mäkelä, R., Krohn, M., Aure, M. R., Nunes-Xavier, C. E., Perälä, M., Tramm, T., Alsner, J., Overgaard, J., Nesland, J. M., Borgen, E., Børresen-Dale, A. L., Fodstad, O., Sahlberg, K. K. & Leivonen, S. K., 1 jan. 2014, I: B J C. 110, 8, s. 2072-2080 9 s.

Hypomethylation and increased expression of the putative oncogene ELMO3 are associated with lung cancer development and metastases formation

Søes, S., Daugaard, I. L., Sørensen, B. S., Carus, A., Mattheisen, M., Alsner, J., Overgaard, J., Hager, H., Hansen, L. L. & Kristensen, L. S., 2014, I: Oncoscience. 1, 5, s. 367-74 8 s.

Hypoxia and radiation therapy

Nordsmark, M., Alsner, J., Busk, M., Overgaard, J. & Horsman, M. R., 2014, Hypoxia and Cancer: Biological Implications and Therapeutic Opportunities. Melilo, G. (red.). New York: Humana Press, s. 265-81 17 s. (Cancer Drug Discovery and Development).

Reliable PCR quantitation of estrogen, progesterone and ERBB2 receptor mRNA from formalin-fixed, paraffin-embedded tissue is independent of prior macro-dissection

Tramm, T., Hennig, G., Kyndi, M., Alsner, J., Sørensen, F. B., Myhre, S., Sørlie, T. & Overgaard, J., dec. 2013, I: Virchows Archiv. 463, 6, s. 775-786 12 s.

Individual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors

Aure, M. R., Leivonen, S-K., Fleischer, T., Zhu, Q., Overgaard, J., Alsner, J., Tramm, T., Louhimo, R., Alnæs, G. I., Perälä, M., Busato, F., Touleimat, N., Tost, J., Børresen-Dale, A-L., Hautaniemi, S., Troyanskaya, O. G., Lingjærde, O. C., Sahlberg, K. K. & Kristensen, V. N., 20 nov. 2013, I: Genome Biology. 14, 11, 20 s., R126.

Independent prospective validation of a predictive test for risk of radiation induced fibrosis based on the gene expression pattern in fibroblasts irradiated in vitro

Andreassen, C. N., Overgaard, J. & Alsner, J., 3 okt. 2013, I: Radiotherapy & Oncology. 108, 3, s. 469-472 4 s.

Hypoxia-regulated gene expression and prognosis in loco-regional gastroesophageal cancer

Winther, M., Alsner, J., Tramm, T. & Nordsmark, M., okt. 2013, I: Acta Oncologica. 52, 7, s. 1327-1335 9 s.

Optimal reference genes for normalization of qRT-PCR data from archival formalin-fixed, paraffin-embedded breast tumors controlling for tumor cell content and decay of mRNA

Tramm, T., Sørensen, B. S., Overgaard, J. & Alsner, J., sep. 2013, I: Diagnostic Molecular Pathology. 22, 3, s. 181-187 7 s.

Radiosensitivity and effect of hypoxia in HPV positive head and neck cancer cells

Sørensen, B. S., Busk, M., Olthof, N., Speel, E-J., Horsman, M. R., Alsner, J. & Overgaard, J., 13 aug. 2013, I: Radiotherapy & Oncology. 108, 3, s. 500-505 6 s.

Identification of accurate reference genes for RT-qPCR analysis of formalin-fixed paraffin-embedded tissue from primary Non-Small Cell Lung Cancers and brain and lymph node metastases.

Søes, S., Sørensen, B. S., Alsner, J., Overgaard, J., Hager, H., Hansen, L. L. & Kristensen, L. S., aug. 2013, I: Lung Cancer. 81, 2, s. 180-186 7 s.

SNP in TXNRD2 Associated With Radiation-Induced Fibrosis: A Study of Genetic Variation in Reactive Oxygen Species Metabolism and Signaling

Edvardsen, H., Landmark-Høyvik, H., Reinertsen, K. V., Zhao, X., Grenaker-Alnæs, G. I., Nebdal, D., Syvänen, A-C., Rødningen, O., Alsner, J., Overgaard, J., Børresen-Dale, A-L., Fosså, S. D. & Kristensen, V. N., 15 jul. 2013, I: International Journal of Radiation Oncology, Biology, Physics. 86, 4, s. 791-799 9 s.

Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins

Myhre, S., Lingjærde, O-C., Hennessy, B. T., Aure, M. R., Carey, M. S., Alsner, J., Tramm, T., Overgaard, J., Mills, G. B., Børresen-Dale, A-L. & Sørlie, T., jun. 2013, I: Molecular Oncology. 7, 3, s. 704-18 15 s.

Peritoneal macrophages mediated delivery of chitosan/siRNA nanoparticle to the lesion site in a murine radiation-induced fibrosis model

Nawroth, I., Alsner, J., Deleuran, B. W., Dagnæs-Hansen, F., Yang, C., Horsman, M. R., Overgaard, J., Howard, K., Kjems, J. & Gao, S., 1 jan. 2013, I: Acta Oncologica. 52, 8, s. 1730-1738 9 s.

Retinoblastoma – Molecular Genetic Analysis of Previously Diagnosed Danish Patients

Gregersen, P. A., Jensen, U. B., Alsner, J., Overgaard, J., Funding, M. & Urbak, S. F., 2013.

Specific degradation pattern of peroxiredoxin-1 correlates with adverse outcome in classical Hodgkin lymphoma patients.

Ludvigsen, M., Kamper, P., Sørensen, B. S., Hamilton Dutoit, S. J., Bendix, K., Møller, M. B., Alsner, J., D'Amore, F. A. & Honoré, B., 2013.

FAZA PET/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: Results from the DAHANCA 24 trial

Mortensen, L. S., Johansen, J., Kallehauge, J. F., Primdahl, H., Busk, M., Lassen, P., Alsner, J., Sørensen, B. S., Toustrup, K., Jakobsen, S., Petersen, J., Petersen, H., Theil, J., Nordsmark, M. & Overgaard, J., okt. 2012, I: Radiotherapy & Oncology. 105, 1, s. 14-20 7 s.

Gene expression classifier predicts for hypoxic modification of radiotherapy with nimorazole in squamous cell carcinomas of the head and neck

Toustrup, K., Sørensen, B. S., Lassen, P., Wiuf, C., Alsner, J., Overgaard, J. & Danish Head and Neck Cancer Group (DAHANCA), jan. 2012, I: Radiotherapy & Oncology. 102, 1, s. 122-129 8 s.

Antiprotons for Radiobiology and Cancer Therapy, the AD-4/ACE Experiment

Holzscheiter, M., Alsner, J., Angelopoulos, A., Bassler, N., Curell, F., Doser, M., Herrmann, R., Jäkel, O., Kaiser, F-J., Kantemiris, I., Kavanagh, J., Keyes, R., Knudsen, H., Overgaard, J., Petersen, J. B. B., Schettino, G., Sellner, S., Sørensen, B. S., Tegami, S., Timson, D. & Tölli, H., 2012, I: Radiotherapy & Oncology. 102, Supplement 1, s. S24-S25 2 s.

Breast irradiation profile. A gene expression signature predicting benefit of radiation therapy in breast cancer patients

Alsner, J., Tramm, T., Børresen-Dale, A. L., Frigessi, A., Mohammed, H., Myhre, S., Sørlie, T. & Overgaard, J., 2012, (Afsendt) IPC nr. U.S. Provisional Patent Application Serial No. 61/607,316

Conducting radiogenomic research--do not forget careful consideration of the clinical data

Andreassen, C. N., Barnett, G. C., Langendijk, J. A., Alsner, J., De Ruysscher, D., Krause, M., Bentzen, S. M., Haviland, J. S., Griffin, C., Poortmans, P. & Yarnold, J. R., 2012, I: Radiotherapy & Oncology. 105, 3, s. 337-40 4 s.

Hypoxia gene expression signatures as prognostic and predictive markers in head and neck radiotherapy

Toustrup, K., Sørensen, B. S., Alsner, J. & Overgaard, J., 2012, I: Seminars in Radiation Oncology. 22, 2, s. 119-127 9 s.

Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity

Barnett, G. C., Elliott, R. M., Alsner, J., Andreassen, C. N., Abdelhay, O., Burnet, N. G., Chang-Claude, J., Coles, C. E., Gutiérrez-Enríquez, S., Fuentes-Raspall, M. J., Alonso-Muñoz, M. C., Kerns, S., Raabe, A., Symonds, R. P., Seibold, P., Talbot, C. J., Wenz, F., Wilkinson, J., Yarnold, J., Dunning, A. M., Rosenstein, B. S., West, C. M. L. & Bentzen, S. M., 2012, I: Radiotherapy & Oncology. 105, 3, s. 289-295 7 s.

Method for determining clinically relevant hypoxia in cancer

Alsner, J., Toustrup, K., Sørensen, B. S., Wiuf, C. H., Nordsmark, M. & Overgaard, J., 2012, IPC nr. C12Q 1/68 (2006.01), A61K 31/415 (2006.01), A61K 31/4164 (2006.01) , Patentnr. WO/2012/146259, 1 nov. 2012

Development of a hypoxia gene expression classifier with predictive impact for hypoxic modification of radiotherapy in head and neck cancer

Toustrup, K., Sørensen, B. S., Nordsmark, M., Busk, M., Wiuf, C., Alsner, J. & Overgaard, J., sep. 2011, I: Cancer Research. 71, 17, s. 5923-31 9 s.

Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer

Gonzalez-Angulo, A. M., Hennessy, B. T., Meric-Bernstam, F., Sahin, A., Liu, W., Ju, Z., Carey, M. S., Myhre, S., Speers, C., Deng, L., Broaddus, R., Lluch, A., Aparicio, S., Brown, P., Pusztai, L., Symmans, W. F., Alsner, J., Overgaard, J., Børresen-Dale, A-L., Hortobagyi, G. N., Coombes, K. R. & Mills, G. B., 8 jul. 2011, I: Clinical Proteomics. 8, 1, s. 11

In vivo Identification and Specificity assessment of mRNA markers of hypoxia in human and mouse tumors

Busk, M., Toustrup, K., Soerensen, B. S., Alsner, J., Horsman, M. R., Jakobsen, S. & Overgaard, J., 9 feb. 2011, I: B M C Cancer. 11, 1, s. 63

Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer

Ytting, H., Christensen, I. J., Steffensen, R. N., Alsner, J., Thiel, S., Jensenius, J. C., Hansen, U. & Nielsen, H. J., 1 feb. 2011, I: Scandinavian Journal of Immunology. 73, 2, s. 122-7 6 s.

Status Report for Experiment AD-4/ACE

Holzscheiter, M., Alsner, J., Angelopoulos, A., Bassler, N., Beyer, G., Boll, R., Caccia, M., Currell, F., Doser, M., Hajdukovic, D., Hartley, O., Herrmann, R., Jäkel, O., Kantemiris, I., Kaiser, F-J., Overgaard, J., Kavanagh, J., Knudsen, H., Keyes, R., Møller, S. P., Negrini, L., Ratib, O., Schettino, G., Sellner, S., Strasse, T., Tegami, S., Timson, D., Tölli, H., Sørensen, B. S., Petersen, J. B. B., Solberg, T. & Welsch, C., 2011, CERN-SPSC. 28 s.

In silico ascription of gene expression differences to tumor and stromal cells in a model to study impact on breast cancer outcome

Myhre, S., Mohammed, H., Tramm, T., Alsner, J., Finak, G., Park, M., Overgaard, J., Børresen-Dale, A-L., Frigessi, A. & Sørlie, T., 1 dec. 2010, I: P L o S One. 5, 11, s. e14002

Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis

Nawroth, I., Alsner, J., Behlke, M. A., Besenbacher, F., Overgaard, J., Howard, K. A. & Kjems, J., 1 okt. 2010, I: Radiotherapy & Oncology. 97, 1, s. 143-8 6 s.

Identifying pH independent hypoxia induced genes in human squamous cell carcinomas in vitro

Sørensen, B. S., Toustrup, K., Horsman, M. R., Overgaard, J. & Alsner, J., okt. 2010, I: Acta Oncologica. 49, 7, s. 895-905 11 s.

Establishment of a Radiogenomics Consortium

West, C., Rosenstein, B. S., Alsner, J., Azria, D., Barnett, G., Begg, A., Bentzen, S., Burnet, N., Chang-Claude, J., Chuang, E., Coles, C., De Ruyck, K., De Ruysscher, D., Dunning, A., Elliott, R., Fachal, L., Hall, J., Haustermans, K., Herskind, C., Hoelscher, T., Imai, T., Iwakawa, M., Jones, D., Kulich, C., Langendijk, J-H., O'Neils, P., Ozsahin, M., Parliament, M., Polanski, A., Rosenstein, B., Seminara, D., Symonds, P., Talbot, C., Thierens, H., Vega, A., West, C., Yarnold, J. & EQUAL-ESTRO, 1 apr. 2010, I: International Journal of Radiation Oncology, Biology, Physics. 76, 5, s. 1295-6 2 s.

Biological Effects of Antiprotons; Are Antiprotons a Candidate for Cancer Therapy?  Status Report for Experiment AD-4/ACE

Holzscheiter, M., Alsner, J., Angelopoulos, A., Bassler, N., Beyer, G., Boll, R., Currell, F., DeMacro, J., Doser, M., Hajdukovic, D., Hartley, O., Iwamoto, K., Jäkel, O., Kantemiris, I., Kaiser, F-J., Kavanagh, J., Keyes, R., Knudsen, H., Kovacevic, S., Møller, S. P., Overgaard, J., Petersen, J. B. B., Ratib, O., Herrmann, R., Schettino, G., Sellner, S., Tegami, S., Timson, D., Tölli, H., Sørensen, B. S., Solberg, T., Vranjes, S., Welsch, C., Weber, P. & Wouters, B., 7 jan. 2010, CERN-SPSC. 44 s.

A technical assessment of the utility of Reverse Phase Protein Arrays for the study of the functional proteome in non-microdissected human breast cancers

Hennessy, B. T., Lu, Y., Gonzalez-Angulo, A. M., Carey, M. S., Myhre, S., Ju, Z., Davies, M. A., Liu, W., Coombes, K., Meric-Bernstam, F., Bedrosian, I., McGahren, M., Agarwal, R., Zhang, F., Overgaard, J., Alsner, J., Neve, R. M., Kuo, W-L., Gray, J. W., Børresen-Dale, A-L. & Mills, G. B., 2010, I: Clinical Proteomics. 6, 4, s. 129-51 23 s.

Biodistribution of 99mTc-HYNIC-lactadherin in mice - a potential tracer for visualizing apoptosis in vivo

Falborg, L., Waehrens, L. N., Alsner, J., Bluhme, H., Frøkiaer, J., Heegaard, C. W., Horsman, M. R., Rasmussen, J. T. & Rehling, M., 2010, I: Scandinavian Journal of Clinical & Laboratory Investigation. 70, 3, s. 209-16 7 s.

HPV-associated p16-expression and response to hypoxic modification of radiotherapy in head and neck cancer

Lassen, P., Eriksen, J. G., Hamilton-Dutoit, S., Tramm, T., Alsner, J. & Overgaard, J., 2010, I: Radiotherapy & Oncology. 94, 1, s. 30-5 6 s.

Treatment of radiation-induced fibrosis

Kjems, J., Overgaard, J., Howard, K., Alsner, J., Besenbacher, F. & Nawroth, I., 2010, Patentnr. WO2010085959A1, 28 jan. 2010

Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer

Agarwal, R., Gonzalez-Angulo, A-M., Myhre, S., Carey, M., Lee, J-S., Overgaard, J., Alsner, J., Stemke-Hale, K., Lluch, A., Neve, R. M., Kuo, W. L., Sorlie, T., Sahin, A., Valero, V., Keyomarsi, K., Gray, J. W., Børresen-Dale, A-L., Mills, G. B. & Hennessy, B. T., 1 jun. 2009, I: Clinical Cancer Research. 15, 11, s. 3654-3662 8 s.

Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck

Lassen, P., Eriksen, J. G., Hamilton-Dutoit, S., Tramm, T., Alsner, J. & Overgaard, J., 20 apr. 2009, I: Journal of Clinical Oncology. 27, 12, s. 1992-8 7 s.

Expression of EGFR and HPV-associated p16 in head and neck cancer: correlation and influence on prognosis after radiotherapy in 1088 patients from the randomised DAHANCA 5, 6 & 7 trials

Lassen, P., Eriksen, J. G., Tramm, T., Hamilton-Dutoit, S. J., Alsner, J. & Overgaard, J., 2009, I: EJC SUPPLEMENTS. 7, 2, s. 470 1 s.

Genetic variants and normal tissue toxicity after radiotherapy: a systematic review

Andreassen, C. N. & Alsner, J., 2009, I: Radiotherapy & Oncology. 92, 3, s. 299-309 10 s.

Prognosis of Distant Metastasis in Node-Negative Early Breast Cancer

Schmidt, M., Tramm, T., Böhm, D., Kyndi, M., Alsner, J., Kölbi, H., Stropp, U., von Törne, C., Weber, K., Henning, G., Gehrmann, M., Sampson, E. & Overgaard, J., 2009. 1 s.

Proteins upregulated by mild and severe hypoxia in squamous cell carcinomas in vitro identified by proteomics

Sørensen, B. S., Horsman, M. R., Vorum, H., Honoré, B., Overgaard, J. & Alsner, J., 2009, I: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 92, 3, s. 443-9 6 s.

Genetic markers for prediction of normal tissue toxicity after radiotherapy

Alsner, J., Andreassen, C. N. & Overgaard, J., apr. 2008, I: Seminars in Radiation Oncology. 18, 2, s. 126-35 9 s.

Carbonic anhydrase IX and response to postmastectomy radiotherapy in high-risk breast cancer: a subgroup analysis of the DBCG82 b and c trials

Kyndi, M., Sørensen, F. B., Knudsen, H., Alsner, J., Overgaard, M., Nielsen, H. M., Overgaard, J. & Danish Breast Cancer Cooperative Group, mar. 2008, I: Breast Cancer Research (Online Edition). 10, 2, s. R24 1 s.

Radiation-induced gene expression in human subcutaneous fibroblasts is predictive of radiation-induced fibrosis

Rødningen, O. K., Børresen-Dale, A-L., Alsner, J., Hastie, T. & Overgaard, J., mar. 2008, I: Radiotherapy & Oncology. 86, 3, s. 314-320 7 s.

Antiproton radiotherapy

Bassler, N., Alsner, J., Beyer, G., DeMarco, J. J., Doser, M., Hajdukovic, D., Hartley, O., Iwamoto, K. S., Jäkel, O., Knudsen, H. V., Kovacevic, S., Møller, S. P., Overgaard, J., Petersen, J. B., Solberg, T. D., Sørensen, B. S., Vranjes, S., Wouters, B. G. & Holzscheiter, M. H., jan. 2008, I: Radiotherapy & Oncology. 86, 1, s. 14-19 6 s.

A comparison among HER2, TP53, PAI-1, angiogenesis, and proliferation activity as prognostic variables in tumours from 408 patients diagnosed with early breast cancer

Offersen, B. V., Alsner, J., Ege Olsen, K., Riisbro, R., Brünner, N., Sørensen, F. B., Sørensen, B. S., Schlemmer, B. O. & Overgaard, J., 2008, I: Acta Oncologica. 47, 4, s. 618-32 15 s.

A comparison between p53 accumulation determined by immunohistochemistry and TP53 mutations as prognostic variables in tumours from breast cancer patients

Alsner, J., Jensen, V., Kyndi, M., Offersen, B. V., Vu, P., Børresen-Dale, A-L. & Overgaard, J., 2008, I: Acta Oncologica. 47, 4, s. 600-7 8 s.

Antiproton therapy

Knudsen, H., Holzscheiter, M. H., Bassler, N., Alsner, J., Beyer, G., DeMarco, J. J., Doser, M., Hajdukovic, D., Hartley, O., Iwamoto, K. S., Jäkel, O., Kovacevic, S., Møller, S. P., Overgaard, J., Petersen, J. B. B., Ratib, O., Solberg, T. D., Vranjes, S., Wouters, B. G. & the CERN ACE Collaboration, 2008, I: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 266, 3, s. 530-534

Differential risk assessments from five hypoxia specific assays: The basis for biologically adapted individualized radiotherapy in advanced head and neck cancer patients

Nordsmark, M., Eriksen, J. G., Gebski, V., Alsner, J., Horsman, M. R. & Overgaard, J., 2008.

HPV- associated p16 positive Head and Neck Squamous Cell Carcinomas Exhibit Improved Prognosis and Response to Radiotherapy

Lassen, P., Eriksen, J. G., Alsner, J., Hamilton-Dutoit, S. J. & Overgaard, J., 2008.

Human papillomavirus in head and neck cancer: a potential prognostic factor and predictor of response to radiotherapy.

Lassen, P., Eriksen, J. G., Alsner, J., Hamilton-Dutoit, S. J. & Overgaard, J., 2008.

Hypoxia induced expression of endogenous markers in vitro is highly influenced by pH

Sørensen, B. S., Horsman, M. R., Overgaard, J. & Alsner, J., 2008.

Impact of BCL2 and p53 on postmastectomy radiotherapy response in high-risk breast cancer. A subgroup analysis of DBCG82 b&c.

Kyndi, M., Sørensen, F. B., Knudsen, H., Alsner, J., Overgaard, M., Nielsen, H. M. & Overgaard, J., 2008, I: Acta Oncologica. 47, 4, s. 608-617 10 s.

The impact of hypoxia on the activity of lactate dehydrogenase in two different pre-clinical tumour models

Lukacova, S., Sørensen, B., Alsner, J., Overgaard, J. & Horsman, M., 2008, I: Acta Oncologica. 47, 5, s. 941-47 7 s.

Transformation of human mesenchymal stem cells in radiation carcinogenesis: long-term effect of ionizing radiation

Christensen, R., Alsner, J., Sørensen, F. B., Dagnaes-Hansen, F., Kolvraa, S. & Serakinci, N., 2008, I: Regenerative Medicine. 3, 6, s. 849-61 12 s.

Differential gene expression before and after ionizing radiation of subcutaneous fibroblasts identifies breast cancer patients resistant to radiation-induced fibrosis

Alsner, J., Rødningen, O. K. & Overgaard, J., jun. 2007, I: Radiotherapy & Oncology. 83, 3, s. 261-266 6 s.

Differential risk assessments from five hypoxia specific assays: The basis for biologically adapted individualized radiotherapy in advanced head and neck cancer patients

Nordsmark, M., Eriksen, J. G., Gebski, V., Alsner, J., Horsman, M. R. & Overgaard, J., jun. 2007, I: Radiotherapy & Oncology. 83, 3, s. 389-397 9 s.

Hypoxia induced expression of endogenous markers in vitro is highly influenced by pH

Sørensen, B. S., Alsner, J., Overgaard, J. & Horsman, M. R., jun. 2007, I: Radiotherapy & Oncology. 83, 3, s. 362-366

Reproductive death of cancer cells induced by femtosecond laser pulses

Thøgersen, J., Knudsen, C. S., Maetzke, A., Jensen, S. K., Keiding, S. R., Alsner, J. & Overgaard, J., maj 2007, I: International Journal of Radiation Biology. 83, 5, s. 289-99 11 s.

Biodistribution and tracer kinetics in small and large animals of 99mTc-HYNIC-lactadherin compared to 99mTc-HYNIC-annexin V

Falborg, L., Wæhrens, L. N., Alsner, J., Dissing, T. H., Eilersen, J., Frøkiær, J., Heegaard, C. W., Horsman, M. R., Rasmussen, J. T., Nielsen, S. S. & Rehling, M., 2007, I: European Journal of Nuclear Medicine and Molecular Imaging. s. S395

Ectopically hTERT expressing adult human mesenchymal stem cells are less radiosensitive than their telomerase negative counterpart.

Serakinci, N., Christensen, R., Graakjaer, J., Cairney, C. J., Keith, W. N., Alsner, J., Saretzki, G., Kolvraa, S. & Christensen, R., 2007, I: Experimental Cell Research. 313, 5, s. 1056-67 11 s.

Focal S100A4 protein expression is an independent predictor of development of metastatic disease in cystectomized bladder cancer patients

Agerbæk, M., Alsner, J., Marcussen, N., Lundbeck, F. & Maase, H. V. D., okt. 2006, I: European Urology. 50, 4, s. 777-785 9 s.

Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM - a study based on DNA from formalin fixed paraffin embedded tissue samples

Andreassen, C. N., Alsner, J., Overgaard, M., Sørensen, F. B. & Overgaard, J., aug. 2006, I: International Journal of Radiation Biology. 82, 8, s. 577-586 10 s.

Strain and tumour specific variations in the effect of hypoxia on osteopontin levels in experimental models

Lukácová, S., Overgaard, J., Alsner, J. & Horsman, M. R., aug. 2006, I: Radiotherapy & Oncology. 80, 2, s. 165-171 7 s.

ATM sequence variants and risk of radiation-induced subcutaneous fibrosis after postmastectomy radiotherapy

Andreassen, C. N., Overgaard, J., Alsner, J., Overgaard, M., Herskind, C., Cesaretti, J. A., Atencio, D. P., Green, S., Formenti, S. C., Stock, R. G. & Rosenstein, B. S., 1 mar. 2006, I: International Journal of Radiation Oncology, Biology, Physics. 64, 3, s. 776-783 8 s.

Is expression of the epidermal growth factor receptor related to hypoxia in squamous cell carcinomas of the head and neck - an evaluation of the DAHANCA 5 study

Eriksen, J. G., Nordsmark, M., Alsner, J., Horsman, M. R., Steinicke, T. & Overgaard, J., 2006, Radiother Oncol. 78 (Suppl.1) udg. s. S38 1 s.

LOH rather than genotypes of TP53 codon 72 is associated with disease-free survival in primary breast cancer

Kyndi, M., Alsner, J., Hansen, L. L., Sørensen, F. B. & Overgaard, J., 2006, I: Acta oncologica (Stockholm, Sweden). 45, 5, s. 602-609 8 s.

Preclinical studies in murine tumours to elucidate the role of serum osteopontin as an endogenous marker of hypoxia

Lukacova, S., Khalil, A. A., Overgaard, J., Alsner, J. & Horsman, M. R., 2006, Radiother. Oncol.. 78 (Suppl.1) udg. s. S31 1 s.

Radiogenomics: predicting clinical normal tissue radiosensitivity

Alsner, J., 2006, Radiother. Oncol.. 81 (Suppl. 1) udg. s. S120 1 s.

Microarray analysis of the transcriptional response to single or multiple doses of ionizing radiation in human subcutaneous fibroblasts

Rødningen, O. K., Overgaard, J., Alsner, J., Hastie, T. & Børresen-Dale, A-L., dec. 2005, I: Radiotherapy & Oncology. 77, 3, s. 231-240 10 s.

Relationship between radiobiological hypoxia in a C3H mouse mammary carcinoma and osteopontin levels in mouse serum

Lukácová, S., Khalil, A. A., Overgaard, J., Alsner, J. & Horsman, M. R., dec. 2005, I: International Journal of Radiation Biology. 81, 12, s. 937-944 8 s.

Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: Results from the DAHANCA 5 randomised double-blind placebo-controlled trial

Overgaard, J., Eriksen, J. G., Nordsmark, M., Alsner, J. & Horsman, M. R., okt. 2005, I: Lancet Oncology. 6, 10, s. 757-764 8 s.

Influence of oxygen concentration and pH on expression of hypoxia induced genes

Sørensen, B. S., Hao, J., Overgaard, J., Vorum, H., Honore, B., Alsner, J. & Horsman, M. R., aug. 2005, I: Radiotherapy & Oncology. 76, 2, s. 187-193 7 s.

The possible role of TP53 mutation status in the treatment of squamous cell carcinomas of the head and neck (HNSCC) with radiotherapy with different overall treatment times

Eriksen, J. G., Alsner, J., Steiniche, T. & Overgaard, J., aug. 2005, I: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 76, 2, s. 135-142 8 s.

TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer

Andreassen, C. N., Alsner, J., Overgaard, J., Herskind, C., Haviland, J., Owen, R., Homewood, J., Bliss, J. & Yarnold, J., 2005, I: Radiotherapy & Oncology. 75, 1, s. 18-21 4 s.

Application of microarray analyses to identify genes involved in radiation-induced fibrosis (RIF)

Rødningen, O. K., Alsner, J., Hastie, T., Overgaard, J. & Børresen-Dale, A-L., 2005, Breast Cancer Res.. 7(Suppl 2) udg. s. S42-S43

Application of microarray analyses to identify genes involved in radiation-induced fibrosis (RIF)

Rødningen, O. K., Alsner, J., Hastie, T., Overgaard, J. & Børresen-Dale, A-L., 2005.

Correlations between clinical normal tissue radiosensitivity and single nucleotide polymorphisms in ATM, XRCC1, XRCC3, APEX, SOD2, and TGF-B1

Alsner, J., Andreassen, C. N., Overgaard, M. & Overgaard, J., 2005.

Influence of oxygen concentration and pH on expression of hypoxia induced genes

Sørensen, B. S., Hao, J., Overgaard, J., Alsner, J. & Horsman, M. R., 2005, Proceedings of the 9th International Wolfsberg Meeting on Molecular Radiation Biology / Oncology. 6 udg. s. 75 1 s.

Prognostic value of genotypes and LOH at TP53 codon 72 and TP53 mutations in primary breast cancer

Kyndi, M., Alsner, J., Hansen, L. L., Sørensen, F. B. & Overgaard, J., 2005.

Prognostic value of genotypes and LOH at TP53 codon 72 and TP53 mutations in primary breast cancer

Kyndi, M., Alsner, J., Hansen, L. L., Sørensen, F. B. & Overgaard, J., 2005, I: Breast Cancer Research (Online Edition). 7, Suppl 2, s. P4.49 1 s.

Validating the use of CAIX and GLUT1 as endogenous markers for hypoxia in solid tumours

Sørensen, B. S., Hao, J., Overgaard, J., Alsner, J. & Horsman, M. R., 2005.

Molecular profiles as predictive marker for the effect of overall treatment time of radiotherapy in supraglottic larynx squamous cell carcinomas

Eriksen, J. G., Buffa, F. M., Alsner, J., Steiniche, T., Bentzen, S. M. & Overgaard, J., sep. 2004, I: Radiotherapy & Oncology. 72, 3, s. 275-282 8 s.

Optimisation and validation of methods to assess single nucleotide polymorphisms (SNPs) in archival histological material

Andreassen, C. N., Sørensen, F. B., Overgaard, J. & Alsner, J., sep. 2004, I: Radiotherapy & Oncology. 72, 3, s. 351-356 6 s.

The prognostic value of epidermal growth factor receptor is related to tumor differentiation and the overall treatment time of radiotherapy in squamous cell carcinomas of the head and neck

Eriksen, J. G., Steiniche, T., Askaa, J., Alsner, J. & Overgaard, J., 1 feb. 2004, I: International Journal of Radiation Oncology, Biology, Physics. 58, 2, s. 561-566 6 s.

Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes

Andreassen, C. N., Alsner, J., Overgaard, M. & Overgaard, J., nov. 2003, I: Radiotherapy & Oncology. 69, 2, s. 127-135 9 s.

Prediction of radiotherapy complications from polymorphisms in candidate genes

Andreassen, C. N., Alsner, J., Overgaard, M. & Overgaard, J., nov. 2003, I: Radiotherapy & Oncology. 69, 2, s. 127-135 9 s.

Retinoblastoma protein expression is an independent predictor of both radiation response and survival in muscle invasive bladder cancer

Agerbæk, M., Alsner, J., Marcussen, N., Lundbeck, F. & Maase, H. V. D., 21 jul. 2003, I: British Journal of Cancer. 89, 2, s. 298-304 7 s.

Isolation and sequencing of heteroduplex fragments from DHPLC analysis of somatic, low-frequency mutations

Alsner, J., 2003, Genetic Variance Detection - Nuts & Bolts of DHPLC in Genomics. Hecker, K. H. (red.). USA: DNA Press, LLC, s. 163-173 11 s.

Spatial evolutionary games of interactions among generic cancer cells.

Bach, L., Sumpter, D., Alsner, J. & Loeschcke, V., 2003, I: Computational and Mathematical Methods in Medicine (Print Edition). 5, 1, s. 47-58 12 s.

Does variability in normal tissue reactions after radiotherapy have a genetic basis - where and how to look for it

Andreassen, C. N., Alsner, J. & Overgaard, J., aug. 2002, I: Radiotherapy & Oncology. 64, 2, s. 131-140 10 s.

An evolutionary-game model of tumour-cell interactions: possible relevance to gene therapy

Bach, L. A., Bentzen, S. M., Alsner, J. & Christiansen, F. B., nov. 2001, I: European Journal of Cancer. 37, 16, s. 2116-2120 5 s.

TP53 mutation is related to poor prognosis after radiotherapy, but not surgery, in squamous cell carcinoma of the head and neck

Alsner, J., Sørensen, S. B. & Overgaard, J., maj 2001, I: Radiotherapy & Oncology. 59, 2, s. 179-185 7 s.

Hypoxia in human soft tissue sarcomas: Adverse impact on survival and no association with p53 mutations

Nordsmark, M., Alsner, J., Keller, J. Ø., Nielsen, O. S., Jensen, O. M. & Overgaard, J., 20 apr. 2001, I: British Journal of Cancer. 84, 8, s. 1070-1075 6 s.

Interaction between potential doubling time and TP53 mutation: predicting radiotherapy outcome in squamous cell carcinoma of the head and neck

Alsner, J., Høyer, M., Sørensen, S. B. & Overgaard, J., 1 feb. 2001, I: International Journal of Radiation Oncology, Biology, Physics. 49, 2, s. 519-525 7 s.

Heterogeneity in the clinical phenotype of TP53 mutations in breast cancer patients

Alsner, J., Yilmaz, M., Guldberg, P., Hansen, L. L. & Overgaard, J., okt. 2000, I: Clinical Cancer Research. 6, 10, s. 3923-31 9 s.

Hypoxia in soft tissue sarcomas:Advanced impact on survival and no association with TP53 mutation

Nordsmark, M., Alsner, J., Keller, J. Ø., Nielsen, O. S., Jensen, O. M. & Overgaard, J., maj 2000.

TP53 mutation is an independent prognostic marker for poor outcome in both node-negative and node-positive breast cancer

Overgaard, J., Yilmaz, M., Guldberg, P., Hansen, L. L. & Alsner, J., 2000, I: Acta oncologica (Stockholm, Sweden). 39, 3, s. 327-33 7 s.

Importance of overall treatment time for the response to radiotherapy in patients with squamous cell carcinoma of the head and neck

Overgaard, J., Alsner, J., Eriksen, J., Horsman, M. R. & Grau, C., 2000, I: Rays. 25, 3, s. 313-9 7 s.

The aggressiveness of hypoxic soft tissue sarcomas cannot be explained by mutations in the TP53 gene

Nordsmark, M., Alsner, J., Keller, J. Ø., Nielsen, O. S., Jensen, O. M. & Overgaard, J., sep. 1999.

Activation of peroxisome proliferator-activated receptor gamma bypasses the function of the retinoblastoma protein in adipocyte differentiation

Hansen, J. B., Petersen, R. K., Larsen, B. M., Bartkova, J., Alsner, J. & Kristiansen, K., 22 jan. 1999, I: Journal of Biological Chemistry. 274, 4, s. 2386-93 8 s.

The effect of shark cartilage extracts on the growth and metastatic spread of the SCCVII carcinoma

Horsman, M. R., Alsner, J. & Overgaard, J., 1998, I: Acta Oncologica. 37, 5, s. 441-5 5 s.

The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis

Bartkova, J., Lukas, J., Guldberg, P., Alsner, J., Kirkin, A. F., Zeuthen, J. & Bartek, J., 1 dec. 1996, I: Cancer Research. 56, 23, s. 5475-83 9 s.

Topoisomerase II-mediated DNA cleavage: evidence for distinct regions of enzyme-DNA contacts

Alsner, J., Sorensen, H. V., Schmidt, V. K., Sorensen, B. S. & Westergaard, O., 14 jun. 1996, I: Journal of Molecular Biology. 259, 3, s. 317-24 8 s.

Intramolecular and intermolecular DNA ligation mediated by topoisomerase II

Schmidt, V. K., Sørensen, B. S., Sørensen, H. V., Alsner, J. & Westergaard, O., 5 aug. 1994, I: Journal of Molecular Biology. 241, 1, s. 18-25 8 s.

Antagonistic effect of aclarubicin on camptothecin induced cytotoxicity: role of topoisomerase I

Sørensen, B. S., Jensen, P. B., Sehested, M., Jensen, P. S., Kjeldsen, E., Nielsen, O. F. & Alsner, J., 1 jun. 1994, I: Biochemical Pharmacology. 47, 11, s. 2105-10 6 s.

A drug-resistant variant of topoisomerase II alpha in human HL-60 cells exhibits alterations in catalytic pH optimum, DNA binding and sub-nuclear distribution

Boege, F., Kjeldsen, E., Gieseler, F., Alsner, J. & Biersack, H., 1 dec. 1993, I: European Journal of Biochemistry. 218, 2, s. 575-84 10 s.

Characterization of an altered DNA catalysis of a camptothecin-resistant eukaryotic topoisomerase I

Gromova, I. I., Kjeldsen, E., Svejstrup, J. Q., Alsner, J., Christiansen, K. & Westergaard, O., 11 feb. 1993, I: Nucleic Acids Research. 21, 3, s. 593-600 8 s.

Eukaryotic type I and type II DNA topoisomerases: modulators of DNA topology and targets for chemotherapy

Alsner, J., 1993, Århus: Institut for Molekylær og Strukturel Biologi, Århus Universitet.

Camptothecin inhibits both the cleavage and religation reactions of eukaryotic DNA topoisomerase I

Kjeldsen, E., Svejstrup, J. Q., Gromova, I. I., Alsner, J. & Westergaard, O., 20 dec. 1992, I: Journal of Molecular Biology. 228, 4, s. 1025-1030 6 s.

Mode of action of topoisomerase II-targeting agents at a specific DNA sequence. Uncoupling the DNA binding, cleavage and religation events

Sørensen, B. S., Sinding, J., Andersen, A. H., Alsner, J., Jensen, P. B. & Westergaard, O., 5 dec. 1992, I: Journal of Molecular Biology. 228, 3, s. 778-786 9 s.

Identification of an N-terminal domain of eukaryotic DNA topoisomerase I dispensable for catalytic activity but essential for in vivo function

Alsner, J., Svejstrup, J. Q., Kjeldsen, E., Sorensen, B. S. & Westergaard, O., 1 jan. 1992, I: Journal of Biological Chemistry. 267, 18, s. 12408-12411 4 s.

Stimulation of topoisomerase II mediated DNA cleavage at specific sequence elements by the 2-nitroimidazole Ro 15-0216

Sørensen, B. S., Jensen, P. S., Andersen, A. H., Christiansen, K., Alsner, J., Thomsen, B. & Westergaard, O., 16 okt. 1990, I: Biochemistry. 29, 41, s. 9507-15 9 s.

Camptothecin-stabilized topoisomerase I-DNA adducts cause premature termination of transcription

Bendixen, C., Thomsen, B., Alsner, J. & Westergaard, O., 12 jun. 1990, I: Biochemistry. 29, 23, s. 5613-5619 7 s.