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Isa Niemann

Recurrence and survival rates in node negative patients after sentinel node biopsy for early-stage vulva cancer – A nationwide study

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Recurrence and survival rates in node negative patients after sentinel node biopsy for early-stage vulva cancer – A nationwide study. / Froeding, Ligita Paskeviciute; Høgdall, Claus; Kristensen, Elisabeth; Zobbe, Vibeke; Niemann, Isa; Ørtoft, Gitte; Thranov, Ingrid; Mathiesen, Ole; Mortensen, Jann; Schnack, Tine Henrichsen.

I: Gynecologic Oncology, Bind 156, Nr. 1, 01.2020, s. 124-130.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Froeding, LP, Høgdall, C, Kristensen, E, Zobbe, V, Niemann, I, Ørtoft, G, Thranov, I, Mathiesen, O, Mortensen, J & Schnack, TH 2020, 'Recurrence and survival rates in node negative patients after sentinel node biopsy for early-stage vulva cancer – A nationwide study', Gynecologic Oncology, bind 156, nr. 1, s. 124-130. https://doi.org/10.1016/j.ygyno.2019.10.024

APA

Froeding, L. P., Høgdall, C., Kristensen, E., Zobbe, V., Niemann, I., Ørtoft, G., Thranov, I., Mathiesen, O., Mortensen, J., & Schnack, T. H. (2020). Recurrence and survival rates in node negative patients after sentinel node biopsy for early-stage vulva cancer – A nationwide study. Gynecologic Oncology, 156(1), 124-130. https://doi.org/10.1016/j.ygyno.2019.10.024

CBE

Froeding LP, Høgdall C, Kristensen E, Zobbe V, Niemann I, Ørtoft G, Thranov I, Mathiesen O, Mortensen J, Schnack TH. 2020. Recurrence and survival rates in node negative patients after sentinel node biopsy for early-stage vulva cancer – A nationwide study. Gynecologic Oncology. 156(1):124-130. https://doi.org/10.1016/j.ygyno.2019.10.024

MLA

Vancouver

Author

Froeding, Ligita Paskeviciute ; Høgdall, Claus ; Kristensen, Elisabeth ; Zobbe, Vibeke ; Niemann, Isa ; Ørtoft, Gitte ; Thranov, Ingrid ; Mathiesen, Ole ; Mortensen, Jann ; Schnack, Tine Henrichsen. / Recurrence and survival rates in node negative patients after sentinel node biopsy for early-stage vulva cancer – A nationwide study. I: Gynecologic Oncology. 2020 ; Bind 156, Nr. 1. s. 124-130.

Bibtex

@article{8bda43d7cd6c40afa52f024bca80827b,
title = "Recurrence and survival rates in node negative patients after sentinel node biopsy for early-stage vulva cancer – A nationwide study",
abstract = "Objective: The sentinel node (SN) procedure is adopted in selected patients with early-stage vulva cancer (VC) in Denmark. Due to the low incidence of VC, large population-based studies on the safety of SN outside multicenter clinical trials are lacking. The current study evaluated the risk of recurrence and survival in SN- negative VC patients. Methods: Nationwide data was collected and registered prospectively in the Danish Gynecologic Cancer Database from January 2011 to July 2017. Patients with clinically stage IB-II unifocal vulva squamous cell carcinoma, tumor <4 cm and no clinically suspicious groin nodes or distant metastases, who underwent SN-procedure, were included. Results: The SN-procedure was performed in 286 patients, of these 190 (66.4%) patients were SN-negative. Twenty-three of the 190 SN-negative patients (12.1%) had one or more recurrences during a median follow-up of 30 months (range 1–83). Four patients (2.1%) had an isolated groin recurrence identified from 5 to 17 months after primary surgery. Fourteen patients (7.4%) experienced a local recurrence in vulva, 1 patient (0.5%) had a recurrence in the vulva and the groin and 4 patients (2.1%) had distant recurrences. The 3-year overall (OS) and disease-specific survival (DSS) for SN-negative patients was 84% and 93%, respectively. The 3-year OS for patients with recurrent disease was 58%. Conclusions: This is the largest prospective nationwide study on SN-procedure in vulva cancer. The study confirms the safety of the SN-procedure in selected early-stage VC patients with a low isolated groin recurrence rate and a good DSS.",
keywords = "Isolated groin recurrence, Sentinel Node procedure, Survival, Vulva cancer",
author = "Froeding, {Ligita Paskeviciute} and Claus H{\o}gdall and Elisabeth Kristensen and Vibeke Zobbe and Isa Niemann and Gitte {\O}rtoft and Ingrid Thranov and Ole Mathiesen and Jann Mortensen and Schnack, {Tine Henrichsen}",
year = "2020",
month = jan,
doi = "10.1016/j.ygyno.2019.10.024",
language = "English",
volume = "156",
pages = "124--130",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Academic Press",
number = "1",

}

RIS

TY - JOUR

T1 - Recurrence and survival rates in node negative patients after sentinel node biopsy for early-stage vulva cancer – A nationwide study

AU - Froeding, Ligita Paskeviciute

AU - Høgdall, Claus

AU - Kristensen, Elisabeth

AU - Zobbe, Vibeke

AU - Niemann, Isa

AU - Ørtoft, Gitte

AU - Thranov, Ingrid

AU - Mathiesen, Ole

AU - Mortensen, Jann

AU - Schnack, Tine Henrichsen

PY - 2020/1

Y1 - 2020/1

N2 - Objective: The sentinel node (SN) procedure is adopted in selected patients with early-stage vulva cancer (VC) in Denmark. Due to the low incidence of VC, large population-based studies on the safety of SN outside multicenter clinical trials are lacking. The current study evaluated the risk of recurrence and survival in SN- negative VC patients. Methods: Nationwide data was collected and registered prospectively in the Danish Gynecologic Cancer Database from January 2011 to July 2017. Patients with clinically stage IB-II unifocal vulva squamous cell carcinoma, tumor <4 cm and no clinically suspicious groin nodes or distant metastases, who underwent SN-procedure, were included. Results: The SN-procedure was performed in 286 patients, of these 190 (66.4%) patients were SN-negative. Twenty-three of the 190 SN-negative patients (12.1%) had one or more recurrences during a median follow-up of 30 months (range 1–83). Four patients (2.1%) had an isolated groin recurrence identified from 5 to 17 months after primary surgery. Fourteen patients (7.4%) experienced a local recurrence in vulva, 1 patient (0.5%) had a recurrence in the vulva and the groin and 4 patients (2.1%) had distant recurrences. The 3-year overall (OS) and disease-specific survival (DSS) for SN-negative patients was 84% and 93%, respectively. The 3-year OS for patients with recurrent disease was 58%. Conclusions: This is the largest prospective nationwide study on SN-procedure in vulva cancer. The study confirms the safety of the SN-procedure in selected early-stage VC patients with a low isolated groin recurrence rate and a good DSS.

AB - Objective: The sentinel node (SN) procedure is adopted in selected patients with early-stage vulva cancer (VC) in Denmark. Due to the low incidence of VC, large population-based studies on the safety of SN outside multicenter clinical trials are lacking. The current study evaluated the risk of recurrence and survival in SN- negative VC patients. Methods: Nationwide data was collected and registered prospectively in the Danish Gynecologic Cancer Database from January 2011 to July 2017. Patients with clinically stage IB-II unifocal vulva squamous cell carcinoma, tumor <4 cm and no clinically suspicious groin nodes or distant metastases, who underwent SN-procedure, were included. Results: The SN-procedure was performed in 286 patients, of these 190 (66.4%) patients were SN-negative. Twenty-three of the 190 SN-negative patients (12.1%) had one or more recurrences during a median follow-up of 30 months (range 1–83). Four patients (2.1%) had an isolated groin recurrence identified from 5 to 17 months after primary surgery. Fourteen patients (7.4%) experienced a local recurrence in vulva, 1 patient (0.5%) had a recurrence in the vulva and the groin and 4 patients (2.1%) had distant recurrences. The 3-year overall (OS) and disease-specific survival (DSS) for SN-negative patients was 84% and 93%, respectively. The 3-year OS for patients with recurrent disease was 58%. Conclusions: This is the largest prospective nationwide study on SN-procedure in vulva cancer. The study confirms the safety of the SN-procedure in selected early-stage VC patients with a low isolated groin recurrence rate and a good DSS.

KW - Isolated groin recurrence

KW - Sentinel Node procedure

KW - Survival

KW - Vulva cancer

UR - http://www.scopus.com/inward/record.url?scp=85075444589&partnerID=8YFLogxK

U2 - 10.1016/j.ygyno.2019.10.024

DO - 10.1016/j.ygyno.2019.10.024

M3 - Journal article

C2 - 31711658

AN - SCOPUS:85075444589

VL - 156

SP - 124

EP - 130

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 1

ER -