Ian Max Møller

Convergent signaling pathways-interaction between methionine oxidation and serine/threonine/tyrosine O-phosphorylation

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • R Shyama Prasad Rao, Division of Biochemistry, University of Missouri, Columbia, USA
  • Ian Max Møller
  • Jay J Thelen, Division of Biochemistry, University of Missouri, Columbia, USA
  • Ján A Miernyk, Division of Biochemistry, University of Missouri, Columbia, Plant Genetics Research Unit, USDA, Agricultural Research Service, University of Missouri, USA

Oxidation of methionine (Met) to Met sulfoxide (MetSO) is a frequently found reversible posttranslational modification. It has been presumed that the major functional role for oxidation-labile Met residues is to protect proteins/cells from oxidative stress. However, Met oxidation has been established as a key mechanism for direct regulation of a wide range of protein functions and cellular processes. Furthermore, recent reports suggest an interaction between Met oxidation and O-phosphorylation. Such interactions are a potentially direct interface between redox sensing and signaling, and cellular protein kinase/phosphatase-based signaling. Herein, we describe the current state of Met oxidation research, provide some mechanistic insight into crosstalk between these two major posttranslational modifications, and consider the evolutionary significance and regulatory potential of this crosstalk.

TidsskriftCell Stress & Chaperones
Sider (fra-til)15-21
Antal sider7
StatusUdgivet - 2015

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