Henrik Gammelager

Perioperative Doppler measurements of renal perfusion are associated with acute kidney injury in patients undergoing cardiac surgery

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Johan Lyngklip Hermansen
  • Gabriela Pettey, University of the Witwatersrand
  • ,
  • Heidi Tofte Sørensen, Department of Cardiothoracic and Vascular Surgery, Odense Universitetshospital, Odense, Denmark., Prehospital section and Department of Anaesthesia, Landspitalinn University Hospital, Reykjavik, Iceland., Hospital Pharmacy, Aarhus University Hospital, Aarhus
  • ,
  • Samantha Nel, University of the Witwatersrand
  • ,
  • Nqoba Tsabedze, University of the Witwatersrand
  • ,
  • Arne Hørlyck
  • Palesa Motshabi Chakane, University of the Witwatersrand
  • ,
  • Henrik Gammelager
  • Peter Juhl-Olsen

Acute kidney injury (AKI) is a frequent and severe complication in cardiac surgery. Normal renal function is dependent on adequate renal perfusion, which may be altered in the perioperative period. Renal perfusion can be assessed with Doppler measurement. We aimed to determine the association between Doppler measurements of renal perfusion and the development of AKI. This was a prospective, observational study of 100 patients with ≥ one risk factor for postoperative AKI undergoing open-heart surgery. Doppler ultrasound examinations were performed before surgery and on the first and fourth postoperative day. AKI was defined according to the KDIGO criteria and subdivided into mild (KDIGO stage 1) and severe AKI (KDIGO stage 2 + 3). Thirty-three patients developed AKI, 25 developed mild and eight developed severe AKI. Abnormal renal venous flow pattern on the first postoperative day was significantly associated with the development of severe AKI (OR 8.54 (95% CI 1.01; 72.2), P = 0.046), as were portal pulsatility fraction (OR 1.07 (95% CI 1.02; 1.13), P = 0.005). Point-of-care Doppler ultrasound measurements of renal perfusion are associated with the development of AKI after cardiac surgery. Renal and portal Doppler ultrasonography can be used to identify patients at high risk or very low risk of AKI after cardiac surgery.

OriginalsprogEngelsk
TidsskriftScientific Reports
Vol/bind11
Nummer1
Sider (fra-til)19738
ISSN2045-2322
DOI
StatusUdgivet - 5 okt. 2021

Bibliografisk note

© 2021. The Author(s).

Se relationer på Aarhus Universitet Citationsformater

ID: 224190056