Projekter pr. år
Personlig profil
Forskning
My research focuses on the molecular mechanisms that underlie neurodegenerative diseases and depression, with a particular interest in the converging pathways that may drive these conditions.
To explore these connections, my lab investigates receptor dynamics as a central theme. We study processes such as receptor trafficking, oligomerization, protein-protein interactions, signaling, and sorting, which are fundamental to understanding how cellular communication and function are altered in both healthy and diseased states.
By integrating molecular, cellular, and whole-organism perspectives, we aim to shed light on the fundamental mechanisms underlying neurodegenerative diseases and depression, with the ultimate goal of identifying potential targets for therapeutic intervention.
Undervisning
Currently, I teach Neurobiology as part of the Master's Programme in Molecular Medicine, as well as Biological Psychiatry under the Master's Programme in Medicine.
Beyond classroom instruction, I supervise Master's and PhD students on research projects that span various aspects of molecular biology and neuroscience.
Fingeraftryk
- 6 Lignende profiler
Samarbejde og topforskningsområder i de sidste fem år
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Exploring a novel biomarker and drug target for Alzheimer's disease and Frontotemporal Dementia. 1.929.840 DKK - Lundbeck Fonden Experiment
Müller, H. K. (PI)
01/05/2024 → 30/04/2026
Projekter: Projekt › Forskning
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Regulating Sortilin ectodomain shedding through a novel molecular switch with relevance to Alzheimer’s disease pathology. 1.992.534 DKK - Lundbeck Fonden Experiment
Müller, H. K. (PI)
01/03/2022 → 29/02/2024
Projekter: Projekt › Forskning
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eMOOD: eMOOD: Novel ideas for better antidepressants 4.500.000 DKK - 'AU Ideas'
Wegener, G. (Projektkoordinator), Elfving, B. (Deltager), Müller, H. K. (Deltager), Nyengaard, J. R. (Deltager), Wainer, I. (Deltager), Kristensen, A. S. (Deltager) & Zarate, C. (Deltager)
01/01/2012 → 31/12/2014
Projekter: Projekt › Forskning
Publikation
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A molecular perspective on mGluR5 regulation in the antidepressant effect of ketamine
Elmeseiny, O. S. A. & Müller, H. K., feb. 2024, I: Pharmacological Research. 200, 107081.Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Review › Forskning › peer review
Åben adgang -
Changes in neurotrophic signaling pathways in brain areas of the chronic mild stress rat model of depression as a signature of ketamine fast antidepressant response/non-response
Derosa, S., Misztak, P., Mingardi, J., Mazzini, G., Müller, H. K. & Musazzi, L., jan. 2024, I: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 128, 9 s., 110871.Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
Åben adgang -
Neuron-specific gene NSG1 binds to and positively regulates sortilin ectodomain shedding via a metalloproteinase-dependent mechanism
Overby, M., Serrano-Rodriguez, A., Dadras, S., Christiansen, A. K., Ozcelik, G., Lichtenthaler, S. F., Weick, J. P. & Müller, H. K., dec. 2023, I: The Journal of Biological Chemistry. 299, 12, s. 105446 1 s., 105446.Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
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Linking Hypothermia and Altered Metabolism with TrkB Activation
Alitalo, O., González-Hernández, G., Rosenholm, M., Kohtala, P., Matsui, N., Müller, H. K., Theilmann, W., Klein, A., Kärkkäinen, O., Rozov, S., Rantamäki, T. & Kohtala, S., sep. 2023, I: ACS Chemical Neuroscience. 14, 17, s. 3212-3225 14 s.Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
Åben adgangFil -
Modulation of the endocannabinoid system by (S)-ketamine in an animal model of depression
Silva, N. R., Arjmand, S., Domingos, L. B., Chaves-Filho, A. M., Mottin, M., Real, C. C., Waszkiewicz, A. L., Gobira, P. H., Ferraro, A. N., Landau, A. M., Andrade, C. H., Müller, H. K., Wegener, G. & Joca, S. R. L., jan. 2025, I: Pharmacological Research. 211, s. 107545 107545.Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
Åben adgang
Aktiviteter
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19th International Neuroscience Winter Conference
Müller, H. K. (Deltager)
26 mar. 2017 → 30 mar. 2017Aktivitet: Deltagelse i eller arrangement af en begivenhed - typer › Deltagelse i eller organisering af konference
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Society for Neuroscience 2016
Müller, H. K. (Deltager)
2016 → …Aktivitet: Deltagelse i eller arrangement af en begivenhed - typer › Deltagelse i eller organisering af konference
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CINP Congress
Müller, H. K. (Deltager)
4 jun. 2015 → 6 jun. 2015Aktivitet: Deltagelse i eller arrangement af en begivenhed - typer › Deltagelse i eller organisering af konference
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Society for Neuroscience 2014
Müller, H. K. (Deltager)
15 nov. 2014 → 19 nov. 2014Aktivitet: Deltagelse i eller arrangement af en begivenhed - typer › Deltagelse i eller organisering af konference
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8th International Meeting on Metabotropic Glutamate Receptors
Müller, H. K. (Deltager)
28 sep. 2014 → 3 okt. 2014Aktivitet: Deltagelse i eller arrangement af en begivenhed - typer › Deltagelse i eller organisering af konference