Hanne Primdahl

Salivary duct carcinoma: a Danish national study

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Salivary duct carcinoma: a Danish national study. / Breinholt, Helle; Elhakim, Mohammad Talal; Godballe, Christian; Andersen, Lisbeth Juhler; Primdahl, Hanne; Kristensen, Claus A; Bjørndal, Kristine.

I: Journal of Oral Pathology & Medicine, Bind 45, Nr. 9, 10.2016, s. 664-671.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Breinholt, H, Elhakim, MT, Godballe, C, Andersen, LJ, Primdahl, H, Kristensen, CA & Bjørndal, K 2016, 'Salivary duct carcinoma: a Danish national study', Journal of Oral Pathology & Medicine, bind 45, nr. 9, s. 664-671. https://doi.org/10.1111/jop.12426

APA

Breinholt, H., Elhakim, M. T., Godballe, C., Andersen, L. J., Primdahl, H., Kristensen, C. A., & Bjørndal, K. (2016). Salivary duct carcinoma: a Danish national study. Journal of Oral Pathology & Medicine, 45(9), 664-671. https://doi.org/10.1111/jop.12426

CBE

Breinholt H, Elhakim MT, Godballe C, Andersen LJ, Primdahl H, Kristensen CA, Bjørndal K. 2016. Salivary duct carcinoma: a Danish national study. Journal of Oral Pathology & Medicine. 45(9):664-671. https://doi.org/10.1111/jop.12426

MLA

Breinholt, Helle o.a.. "Salivary duct carcinoma: a Danish national study". Journal of Oral Pathology & Medicine. 2016, 45(9). 664-671. https://doi.org/10.1111/jop.12426

Vancouver

Breinholt H, Elhakim MT, Godballe C, Andersen LJ, Primdahl H, Kristensen CA o.a. Salivary duct carcinoma: a Danish national study. Journal of Oral Pathology & Medicine. 2016 okt;45(9):664-671. https://doi.org/10.1111/jop.12426

Author

Breinholt, Helle ; Elhakim, Mohammad Talal ; Godballe, Christian ; Andersen, Lisbeth Juhler ; Primdahl, Hanne ; Kristensen, Claus A ; Bjørndal, Kristine. / Salivary duct carcinoma: a Danish national study. I: Journal of Oral Pathology & Medicine. 2016 ; Bind 45, Nr. 9. s. 664-671.

Bibtex

@article{d3fe9d6d5a9f454585b585e5c877f661,
title = "Salivary duct carcinoma: a Danish national study",
abstract = "BACKGROUND:To present the first national series of salivary duct carcinoma patients, including survival rates and an analysis of prognostic factors.METHODS:By merging three Danish nationwide registries that encompass an entire population, 34 patients diagnosed with salivary duct carcinoma from 1990 to 2005 were identified. Histological slides were reviewed, and data concerning demographics, tumour site, clinical stage, treatment profiles and follow-up were retrieved. Survival estimates and prognostic factors were evaluated by comparing Kaplan-Meier plots using the Mantel-Haenszel log-rank test.RESULTS:Salivary duct carcinoma showed an incidence of 0.04/100.000 inhabitants/year. Distant recurrence was seen in 52% of patients. Five-year overall survival, disease-specific survival and recurrence-free survival were 32%, 42% and 35%, respectively. Univariate analyses suggested that overall stage (III/IV) and vascular invasion have a negative impact on all survival measures. Involved resection margins correlated with a poorer overall survival and disease-specific survival, whereas adjuvant radiotherapy improved overall survival and recurrence-free survival.CONCLUSIONS:Salivary duct carcinoma incidence averages to two episodes per year in the entire Kingdom of Denmark. With half of patients in this study experiencing distant recurrences and only a third surviving at 5 years, prognosis is dismal. Advanced overall stage, vascular invasion and involved resection margins all seem to correlate with a poorer survival, while adjuvant radiotherapy significantly improved outcome. Extensive T-site surgery, neck dissection and adjuvant radiotherapy are therefore recommended.",
author = "Helle Breinholt and Elhakim, {Mohammad Talal} and Christian Godballe and Andersen, {Lisbeth Juhler} and Hanne Primdahl and Kristensen, {Claus A} and Kristine Bj{\o}rndal",
note = "{\textcopyright} 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
year = "2016",
month = oct,
doi = "10.1111/jop.12426",
language = "English",
volume = "45",
pages = "664--671",
journal = "Journal of Oral Pathology & Medicine",
issn = "0904-2512",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "9",

}

RIS

TY - JOUR

T1 - Salivary duct carcinoma: a Danish national study

AU - Breinholt, Helle

AU - Elhakim, Mohammad Talal

AU - Godballe, Christian

AU - Andersen, Lisbeth Juhler

AU - Primdahl, Hanne

AU - Kristensen, Claus A

AU - Bjørndal, Kristine

N1 - © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2016/10

Y1 - 2016/10

N2 - BACKGROUND:To present the first national series of salivary duct carcinoma patients, including survival rates and an analysis of prognostic factors.METHODS:By merging three Danish nationwide registries that encompass an entire population, 34 patients diagnosed with salivary duct carcinoma from 1990 to 2005 were identified. Histological slides were reviewed, and data concerning demographics, tumour site, clinical stage, treatment profiles and follow-up were retrieved. Survival estimates and prognostic factors were evaluated by comparing Kaplan-Meier plots using the Mantel-Haenszel log-rank test.RESULTS:Salivary duct carcinoma showed an incidence of 0.04/100.000 inhabitants/year. Distant recurrence was seen in 52% of patients. Five-year overall survival, disease-specific survival and recurrence-free survival were 32%, 42% and 35%, respectively. Univariate analyses suggested that overall stage (III/IV) and vascular invasion have a negative impact on all survival measures. Involved resection margins correlated with a poorer overall survival and disease-specific survival, whereas adjuvant radiotherapy improved overall survival and recurrence-free survival.CONCLUSIONS:Salivary duct carcinoma incidence averages to two episodes per year in the entire Kingdom of Denmark. With half of patients in this study experiencing distant recurrences and only a third surviving at 5 years, prognosis is dismal. Advanced overall stage, vascular invasion and involved resection margins all seem to correlate with a poorer survival, while adjuvant radiotherapy significantly improved outcome. Extensive T-site surgery, neck dissection and adjuvant radiotherapy are therefore recommended.

AB - BACKGROUND:To present the first national series of salivary duct carcinoma patients, including survival rates and an analysis of prognostic factors.METHODS:By merging three Danish nationwide registries that encompass an entire population, 34 patients diagnosed with salivary duct carcinoma from 1990 to 2005 were identified. Histological slides were reviewed, and data concerning demographics, tumour site, clinical stage, treatment profiles and follow-up were retrieved. Survival estimates and prognostic factors were evaluated by comparing Kaplan-Meier plots using the Mantel-Haenszel log-rank test.RESULTS:Salivary duct carcinoma showed an incidence of 0.04/100.000 inhabitants/year. Distant recurrence was seen in 52% of patients. Five-year overall survival, disease-specific survival and recurrence-free survival were 32%, 42% and 35%, respectively. Univariate analyses suggested that overall stage (III/IV) and vascular invasion have a negative impact on all survival measures. Involved resection margins correlated with a poorer overall survival and disease-specific survival, whereas adjuvant radiotherapy improved overall survival and recurrence-free survival.CONCLUSIONS:Salivary duct carcinoma incidence averages to two episodes per year in the entire Kingdom of Denmark. With half of patients in this study experiencing distant recurrences and only a third surviving at 5 years, prognosis is dismal. Advanced overall stage, vascular invasion and involved resection margins all seem to correlate with a poorer survival, while adjuvant radiotherapy significantly improved outcome. Extensive T-site surgery, neck dissection and adjuvant radiotherapy are therefore recommended.

U2 - 10.1111/jop.12426

DO - 10.1111/jop.12426

M3 - Journal article

C2 - 26822194

VL - 45

SP - 664

EP - 671

JO - Journal of Oral Pathology & Medicine

JF - Journal of Oral Pathology & Medicine

SN - 0904-2512

IS - 9

ER -