Hamidreza Ardalani

Ph.d.-studerende

Hamidreza Ardalani

Profil

I received my M.Sc. in chemistry of medicinal plants at IAU, Iran, where I studied the effects of plant’s hormones on biochemical responses. Meantime, I was involved in the researches about the clinical efficacy of plant’s secondary metabolites (PSMs) on hyperlipidemia, hypertension and diabetes. As a research assistant at University of Copenhagen, I conducted a study on metabolite profiling of endophytic fungi to discover antidiabetic and antibiotic compounds and validated a high-resolution method to find the antibacterial bioactive compounds from complex crude extracts. Currently, I am working on my Ph.D. at Aarhus University, studying the uptake and metabolization of phytochemicals and pesticides in honey bees. I endeavor to clarify some agro-chemical inquiries using a combination of state-of-the-art techniques such as chromatography, mass spectrometry, RT-qPCR and metabolomics.

 

Ph.D. project: Uptake and metabolisation of phytochemicals and pesticides in honey bees

Aims: Honey bees are ideal pollinators and subject to numerous stresses such as reduced flower diversity, new parasites, and chronical exposure to agrochemicals. In this project, I attempt to investigate the effects of PSMs on the detoxification system of honey bees and the sacbrood virus (SBV) level when the bees are co-exposed to selected pesticides. The combination of analytical techniques (LC-Qtrap-MS/MS, GC-TOF-MS, UPLC-Orbitrap-MS/MS, NMR), biological approaches (RT-qPCR), and state-of-the-art metabolomics will provide a comprehensive approach in addressing agro-ecological questions. Investigating how PSMs can up-regulate bees' systems to detoxify xenobiotics and identification of the enzymes involved in this process can elucidate how bees face the toxicity of chemicals in an agricultural setting.

 

Interests:

Metabolomics

Natural products chemistry

Chemical ecology

Toxicology

ID: 118840795